3-(3-ethoxy-phenyl)-2-methyl-acrylic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-(3-ethoxy-phenyl)-2-methyl-acrylic acid
• 英文别名: 3-(3-Aethoxy-phenyl)-2-methyl-acrylsaeure；(E)-3-(3-ethoxyphenyl)-2-methylprop-2-enoic acid
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: LBRJHGHWMLVLAV-VQHVLOKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  间羟基苯甲醛 在 氢氧化钾 、 乙醇 、 乙酸酐 作用下， 生成 3-(3-ethoxy-phenyl)-2-methyl-acrylic acid
  参考文献：
  名称：

  Werner, Chemische Berichte, 1895, vol. 28, p. 1999

  摘要：

  DOI：

文献信息

• Antifungal Pharmacodynamic Characteristics of Amphotericin B against<i>Trichosporon asahii</i>, Using Time-Kill Methodology
  作者：Yoshimi Toriumi、Takashi Sugita、Masamitsu Nakajima、Toshiharu Matsushima、Takako Shinoda

  DOI：10.1111/j.1348-0421.2002.tb02663.x

  日期：2002.2

  AbstractWe determined the MIC of amphotericin B against 45 Trichosporon asahii isolates from various clinical and environmental sources, and used in vitro time‐kill methods to characterize the relationship between amphotericin B concentrations and MIC for four representative T. asahii isolates. Amphotericin B had concentration‐dependent antifungal activity. MICs ranged from 0.5 to 16 μg/ml, and most T. asahii isolates (76%, 34/45) were inhibited at safely achievable amphotericin B serum concentrations (≤ 2 μg/ml). However, 40% (18/45) of isolates were not killed at these concentrations (MFCs from 1.0 to 32 μg/ml). At concentrations ≥ 2 × MIC, amphotericin B exhibited fungicidal activity (< 99.9% reduction in CFU) over a 12‐hr time‐period; the maximal effect was achieved at ≥ 4 × MIC. Susceptibility testing confirmed the resistance of T. asahii to amphotericin B, and in vitro pharmacodynamic results also suggest that amphotericin B is not suitable therapy for T. asahii infection.
• Werner, Chemische Berichte, 1895, vol. 28, p. 1999
  作者：Werner

  DOI：——

  日期：——