4-oxodocosanoic acid | 115097-01-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-oxodocosanoic acid
• 英文别名: 4-oxo-docosanoic acid；4-Oxo-docosansaeure
• CAS: 115097-01-3
• 化学式: C₂₂H₄₂O₃
• 分子量: 354.574
• InChiKey: HZKNWRQSWZMFSK-UHFFFAOYSA-N

物化性质

• 沸点：
  182-184 °C(Press: 0.003 Torr)
• 密度：
  0.924±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  25
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-oxodocosanoic acid 在 sodium hydroxide 、 一水合肼 、 二乙二醇 作用下， 生成 二十二酸
  参考文献：
  名称：

  Oura et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1956, vol. 76, p. 1433

  摘要：

  DOI：
• 作为产物：
  描述：

  二十二碳六烯酸 在 palladium on activated charcoal 2,4,6-三甲基吡啶 、 氢氧化钾 、 草酰氯 、 氢气 、 碘 、 二甲基亚砜 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 水 、 乙腈 、 苯 为溶剂， 反应 24.0h， 生成 4-oxodocosanoic acid
  参考文献：
  名称：

  Synthesis of docosahexaenoic acid derivatives designed as novel PPARγ agonists and antidiabetic agents

  摘要：

  To discover novel peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists that Could be used as antidiabetic agents, we designed docosahexacnoic acid (DHA) derivatives (2 and 3), which have a hydrophilic substituent at the C(4)-position, based on the crystal structure of the ligand-binding pocket of PPAR gamma. These compounds were synthesized via iodolactolic as a key intermediate. We found that both DHA derivatives (2 and 3) showed PPAR gamma transactivation higher than, or comparable to, that of pioglitazone, which is a TZD derivative used as an antidiabetic agent. DHA derivatives related to these potent Compounds 2 and 3 were also synthesized to study structure-activity relationships. Furthermore, 4-OH DHA 2, which shows strong PPAR gamma transcriptional activity, was separated as an optically pure form. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.07.074

文献信息

• Shukow; Schestakow, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1908, vol. 40, p. 836
  作者：Shukow、Schestakow

  DOI：——

  日期：——
• Lukes; Cerny, Collection of Czechoslovak Chemical Communications, 1958, vol. 23, p. 497,500
  作者：Lukes、Cerny

  DOI：——

  日期：——
• Image display medium, process for forming image, and multicolor image-forming apparatus
  申请人：——

  公开号：US20030184644A1

  公开（公告）日：2003-10-02

  An image display medium that includes a photoconductive layer containing a photochromic compound and an electron accepting compound; and a substrate, in which the photochromic compound contains a fulgide compound, and the electron accepting compound contains a compound selected at least from: a) a phosphonic acid compound having an aliphatic group containing 12 or more carbon atoms; b) an aliphatic carboxylic acid compound having an aliphatic group containing 12 or more carbon atoms; and c) a phenolic compound having an aliphatic group containing 12 or more carbon atoms, a process for forming an image using the medium, and a multicolor image-forming apparatus using the medium and suitable for the process.
• US5395433A
  申请人：——

  公开号：US5395433A

  公开（公告）日：1995-03-07
• US7029833B2
  申请人：——

  公开号：US7029833B2

  公开（公告）日：2006-04-18