N-benzoyl-DL-glutamic acid-anhydride | 91569-94-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-benzoyl-DL-glutamic acid-anhydride
• 英文别名: N-Benzoyl-DL-glutaminsaeure-anhydrid；N-(Tetrahydro-2,6-dioxo-2H-pyran-3-yl)benzamide；N-(2,6-dioxooxan-3-yl)benzamide
• CAS: 91569-94-7
• 化学式: C₁₂H₁₁NO₄
• 分子量: 233.224
• InChiKey: MYBJHWJWVVIFAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-benzoyl-DL-glutamic acid-anhydride 在 氢氧化钾 、 氯化亚砜 作用下， 生成 diethyl 2-benzamidopentanedioate
  参考文献：
  名称：

  407.肽链特异性化学裂变的研究。第二部分 α-谷氨酰胺肽衍生的1-酰基吡咯烷酮-2-酮的制备和水解

  摘要：

  DOI：

  10.1039/jr9560002076
• 作为产物：
  描述：

  N-苯甲酰基-DL-谷氨酸 在 乙酸酐 作用下， 生成 N-benzoyl-DL-glutamic acid-anhydride
  参考文献：
  名称：

  Bullerwell et al., Journal of the Chemical Society, 1954, p. 3283,3287

  摘要：

  DOI：

文献信息

• Distress and disease status among patients with rheumatoid arthritis: Roles of coping styles and perceived responses from support providers
  作者：Kenneth W. Griffin、Ronald Friend、Alan T. Kaell、Ronald S. Bennett

  DOI：10.1207/s15324796abm2302_8

  日期：2001.5

  Previous research has shown that social support can have a beneficial impact on coping processes and psychological adjustment in patients with rheumatoid arthritis (RA). The association of individual coping styles and perceived responses from others to one's pain episodes with patients' distress and disease status over time was investigated. The sample consisted of 42 middle-aged patients with RA who were predominantly White (98%), female (64%), and married (88%). Participants completed surveys and their rheumatologist completed clinical assessments of patient disease status at 2 time points over a 9-month period Although punishing responses from others (e.g, getting irritated or angry when the patient is in pain) were perceived as relatively infrequent, they were associated with a patient coping style of focusing on and venting of negative emotion as well as elevated negative affect (NA). Findings also indicated that those who perceived punishing responses from close others and coped by venting negative emotions reported increased NA over time and were rated by their rheumatologist as having more severe RA disease status over time. Implications for psychosocial intervention and directions for future research are discussed.
• Studies on specific chemical fission of peptide links. Part I. The rearrangement of aspartyl and glutamyl peptides
  作者：Alan R. Battersby、J. C. Robinson

  DOI：10.1039/jr9550000259

  日期：——
• Makovec; Chiste; Bani, European Journal of Medicinal Chemistry, 1986, vol. 21, # 1, p. 9 - 20
  作者：Makovec、Chiste、Bani、et al.

  DOI：——

  日期：——
• Bullerwell et al., Journal of the Chemical Society, 1954, p. 3283,3287
  作者：Bullerwell et al.

  DOI：——

  日期：——
• 407. Studies on specific chemical fission of peptide links. Part II. The preparation and hydrolysis of 1-acylpyrrolid-2-ones derived from α-glutamyl peptides
  作者：Alan R. Battersby、J. C. Robinson

  DOI：10.1039/jr9560002076

  日期：——