4-(3-Chloro-5-trifluoromethyl-pyridin-2-yloxy)phenoxyacetic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(3-Chloro-5-trifluoromethyl-pyridin-2-yloxy)phenoxyacetic acid
• 英文别名: 4-(3-Chloro-5-trifluoromethyl-2-pyridyloxy)phenoxyacetic acid；4-[3-Chloro-5-(trifluoromethyl)-2-pyridyloxy]phenoxyacetic acid；2-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxyphenoxy]acetic acid
• 化学式: C₁₄H₉ClF₃NO₄
• 分子量: 347.678
• InChiKey: ZDGKUJLBXPEMPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  68.6
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4-(3-Chloro-5-trifluoromethyl-pyridin-2-yloxy)phenoxyacetic acid 、 1,3-二氯丙酮 生成 (3-Chloro-2-oxo)propyl 4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxyacetate
  参考文献：
  名称：

  XASIMOTO, MASAKI;FUKAMI, DZIITA

  摘要：

  DOI：

文献信息

• Herbicidally active phenoxyalkanecarboxylic acid derivatives
  申请人：Suntory Limited

  公开号：US04976773A1

  公开（公告）日：1990-12-11

  A compound of the formula: ##STR1## wherein Q.sup.1 is CH or N; R is H or C.sub.1 -C.sub.5 alkyl; X is H, halogen, CF.sub.3, or NO.sub.2 ; Y is H or halogen; Z is --O-- or --NH--; A is ##STR2## wherein Q.sup.2, and Q.sup.3 are each CH or N; R.sup.1 and R.sup.2 are each H, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, or C.sub.2 -C.sub.6 alkxoycarobnyl; R.sup.3, R.sup.4, and R.sup.5 are each H or C.sub.1 -C.sub.5 alkyl; R.sup.6 is H, halogen, or C.sub.1 -C.sub.5 alkyl; R.sup.7, R.sup.8, R.sup.9, and R.sup.10 are each H or C.sub.1 -C.sub.5 alkyl; R.sup.11 is H, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, C.sub.2 -C.sub.6 alkenyl, C.sub.6 -C.sub.10 aryl, C.sub.7 -C.sub.15 aryloxyalkyl, or C.sub.7 -C.sub.15 aralkyl; R.sup.12 and R.sup.13 are each H or C.sub.1 -C.sub.5 alkyl; R.sup.14 is C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.5 -C.sub.10 aryl, or C.sub.7 -C.sub.15 aralkyl; or R.sup.13 and R.sup.14 taken together form C.sub.3 -C.sub.4 alkylene, V.sup.1 and V.sup.2 are each H, halogen, NO.sub.2, CN, or CF.sub.3 ; V.sup.3 is halogen or CF.sub.3 ; W.sup.1 is --O-- or --NH--; W.sup.2 is --(CH.sub.2).sub.n -- wherein n is 0 or 1, or CO; X.sup.1 is halogen, or a salt thereof, which is effective as a herbicidal agent.

  一种化合物的公式：##STR1## 其中Q.sup.1为CH或N；R为H或C.sub.1 -C.sub.5烷基；X为H、卤素、CF.sub.3或NO.sub.2；Y为H或卤素；Z为--O--或--NH--；A为##STR2## 其中Q.sup.2和Q.sup.3均为CH或N；R.sup.1和R.sup.2均为H、C.sub.1 -C.sub.5烷基、C.sub.1 -C.sub.5烷氧基或C.sub.2 -C.sub.6烷氧羰基；R.sup.3、R.sup.4和R.sup.5均为H或C.sub.1 -C.sub.5烷基；R.sup.6为H、卤素或C.sub.1 -C.sub.5烷基；R.sup.7、R.sup.8、R.sup.9和R.sup.10均为H或C.sub.1 -C.sub.5烷基；R.sup.11为H、C.sub.1 -C.sub.5烷基、C.sub.1 -C.sub.5烷氧基、C.sub.2 -C.sub.6烯基、C.sub.6 -C.sub.10芳基、C.sub.7 -C.sub.15芳氧基烷基或C.sub.7 -C.sub.15芳基烷基；R.sup.12和R.sup.13均为H或C.sub.1 -C.sub.5烷基；R.sup.14为C.sub.1 -C.sub.5烷基、C.sub.2 -C.sub.6烯基、C.sub.5 -C.sub.10芳基或C.sub.7 -C.sub.15芳基烷基；或R.sup.13和R.sup.14一起形成C.sub.3 -C.sub.4烷基；V.sup.1和V.sup.2均为H、卤素、NO.sub.2、CN或CF.sub.3；V.sup.3为卤素或CF.sub.3；W.sup.1为--O--或--NH--；W.sup.2为--(CH.sub.2).sub.n--其中n为0或1，或CO；X.sup.1为卤素或其盐，作为除草剂有效。
• Substituted phenoxyalkane diones, intermediates for these compounds and the use of phenoxyalkane diones in the control of weeds
  申请人：ZOECON CORPORATION

  公开号：EP0109483A1

  公开（公告）日：1984-05-30

  Compounds of the following formula (A): wherein, R is or R1 is hydrogen or lower alkyl; R2 is lower alkyl; W is oxygen, sulfur or amino; Q is oxygen or sulfur; each of Y and Z is independently selected from hydrogen, lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxy, halogen, nitro and cyano; and each of X' and X" is independently selected from hydrogen lower haloalkyl, lower alkoxy, halogen and nitro, provided that both X' and X" cannot be trifluoromethyl, methoxy or nitro; suitable intermediates and the use of said compounds for the control of weeds.

  下式(A)的化合物： 其中 R 是 或 R1 是氢或低级烷基 R2 是低级烷基 W是氧、硫或氨基 Q 是氧或硫；Y 和 Z 各自独立地选自氢、低级烷基、低级卤代烷基、低级烷氧基、低级卤代烷氧基、卤素、硝基和氰基；以及 X' 和 X "各自独立选自氢、低级卤代烷基、低级烷氧基、卤素和硝基，但 X' 和 X "不能是三氟甲基、甲氧基或硝基； 合适的中间体以及所述化合物在控制杂草方面的用途。
• Herbicide resistance genes
  申请人：Dow AgroSciences LLC

  公开号：US10174337B2

  公开（公告）日：2019-01-08

  The subject invention provides novel plants that are not only resistant to 2,4-D and other phenoxy auxin herbicides, but also to aryloxyphenoxypropionate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention alone or “stacked” together with another herbicide resistance gene, preferably a glyphosate resistance gene, so as to provide broader and more robust weed control, increased treatment flexibility, and improved herbicide resistance management options. More specifically, preferred enzymes and genes for use according to the subject invention are referred to herein as AAD (aryloxyalkanoate dioxygenase) genes and proteins. No α-ketoglutarate-dependent dioxygenase enzyme has previously been reported to have the ability to degrade herbicides of different chemical classes and modes of action. This highly novel discovery is the basis of significant herbicide tolerant crop trait opportunities as well as development of selectable marker technology. The subject invention also includes related methods of controlling weeds. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the formation of, and controlling, weeds that are resistant (or naturally more tolerant) to one or more herbicides such as glyphosate.

  本发明提供的新型植物不仅能抗 2,4-D 和其他苯氧基助剂除草剂，还能抗芳基氧基苯氧基丙酸酯除草剂。在此之前，人们并不期望或认为通过引入单一基因就能培育出同时具有这两种优势特性的植物。本发明还包括单独产生一种或多种本发明酶的植物，或与另一种除草剂抗性基因（最好是草甘膦抗性基因）"叠加 "在一起的植物，从而提供更广泛、更强大的杂草控制，增加处理灵活性，改进除草剂抗性管理选择。更具体地说，根据本发明使用的优选酶和基因在此称为 AAD（芳氧基烷酸二加氧酶）基因和蛋白。以前没有报道过依赖于α-酮戊二酸的二加氧酶具有降解不同化学类别和作用方式的除草剂的能力。这一高度新颖的发现是重要的耐除草剂作物性状机会以及可选择标记技术发展的基础。本发明还包括控制杂草的相关方法。本发明可使除草剂的新组合以新的方式使用。此外，本发明还提供了防止形成和控制对一种或多种除草剂（如草甘膦）具有抗性（或天然更耐受）的杂草的新方法。
• Aryloxyphenoxypropionate tolerance in turfrgass species and use of AAD1 as a selectable marker
  申请人：Dow AgroSciences, LLC

  公开号：US10450549B2

  公开（公告）日：2019-10-22

  The present disclosure relates to the use of a grass-active herbicide postemergently applied to AAD1-transformed turfgrasses to selectively control grass weeds in a turf grass crop. Also described is the use of AAD1 as a selectable marker in the production of transgenic turfgrass.

  本公开涉及一种禾本科活性除草剂在苗后施用到 AAD1 转化的草坪草上，以选择性地控制草坪草作物中的禾本科杂草。还描述了在转基因草坪草的生产中使用 AAD1 作为可选择标记。
• HERBICIDAL ORGANO-PHOSPHORUS COMPOUNDS
  申请人：TEIJIN LIMITED

  公开号：EP0433446B1

  公开（公告）日：1992-12-30