[4-(氨基甲基)环己基]甲醇 | 1074-62-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: [4-(氨基甲基)环己基]甲醇
• 英文名称: 4-(aminomethyl)-cyclohexanemethanol
• 英文别名: 4-(aminomethyl)cyclohexan-1-yl methanol；(trans)-(4-hydroxymethyl-cyclohexyl)-methyl-amine；1-hydroxymethyl-4-aminomethylcyclohexane；(4-(aminomethyl)cyclohexyl)methanol；[4-(aminomethyl)cyclohexyl]methanol；4-(aminomethyl)cyclohexanemethanol
• CAS: 1074-62-0
• 化学式: C₈H₁₇NO
• mdl: MFCD00152235
• 分子量: 143.229
• InChiKey: WWDKVICMJWBJKJ-UHFFFAOYSA-N

物化性质

• 沸点：
  243.4±13.0 °C(Predicted)
• 密度：
  0.956±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  [4-(氨基甲基)环己基]甲醇 生成 N-Benzyl-1-benzyloxymethyl-4-cyclohexanemethylamine
  参考文献：
  名称：

  影响脂质代谢的物质。二十一 与反式1,4-双（2-氯苄氨基甲基）环己烷有关的杂物。

  摘要：

  DOI：

  10.1021/jm00321a055
• 作为产物：
  描述：

  tranexamic acid 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以36 %的产率得到[4-(氨基甲基)环己基]甲醇
  参考文献：
  名称：

  设计为 EcDsbA 共价修饰物的氟甲基酮片段偶联物是非典型底物

  摘要：

  我们报道了氧化还原酶 DsbA 可以翻转巯基反应官能团，例如氟甲基酮和马来酰亚胺。

  DOI：

  10.1002/cmdc.202300684

文献信息

• [EN] ROR-GAMMA INHIBITORS<br/>[FR] INHIBITEURS DE ROR-GAMMA
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2019063748A1

  公开（公告）日：2019-04-04

  The present invention relates to compounds of formula I and pharmaceutical compositions comprising compounds of formula I. Compounds of Formula I are useful in treatment of inflammatory, metabolic or autoimmune diseases which are mediated by RORy.

  本发明涉及公式I的化合物和包含公式I化合物的药物组合物。公式I的化合物在治疗由RORγ介导的炎症性、代谢性或自身免疫性疾病方面是有用的。
• PROCESS FOR PREPARING DI-, TRI- AND POLYAMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION
  申请人：SCHAUB Thomas

  公开号：US20120232293A1

  公开（公告）日：2012-09-13

  Process for preparing primary amines which have at least one functional group of the formula (—CH 2 —NH 2 ) and at least one further primary amino group by alcohol amination of starting materials having at least one functional group of the formula (—CH 2 —OH) and at least one further functional group (—X), where (—X) is selected from among hydroxyl groups and primary amino groups, by means of ammonia with elimination of water, wherein the reaction is carried out homogeneously catalyzed in the presence of at least one complex catalyst comprising at least one element selected from groups 8, 9 and 10 of the Periodic Table and also at least one donor ligand.

  通过醇胺化起始物质制备至少具有一个功能基团（—CH2—NH2）和至少一个进一步的初级氨基基团的初级胺的过程，其中起始物质至少具有一个功能基团（— —OH）和至少一个进一步的功能基团（—X），其中（—X）从羟基和初级氨基中选择，通过氨与水的消除，反应在至少包含来自周期表8、9和10族中选择的至少一个元素以及至少一个给体配体的至少一个复合催化剂的存在下均匀催化进行。
• 6-(6-MEMBERED HETEROARYL & ARYL)ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
  申请人：Samumed, LLC

  公开号：US20190125740A1

  公开（公告）日：2019-05-02

  Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

  揭示了用于治疗各种疾病和病理的异喹啉化合物。更具体地，本公开涉及使用异喹啉化合物或其类似物治疗由Wnt途径信号激活所特征的疾病（例如癌症、异常细胞增殖、血管生成、阿尔茨海默病、肺部疾病、炎症、自身免疫疾病和骨关节炎），调节由Wnt途径信号介导的细胞事件，以及与DYRK1A过表达相关的神经状况/疾病/疾病。
• Durable coating compositions containing novel aspartic amine compounds
  申请人：Lenges Peter Christian

  公开号：US20060155148A1

  公开（公告）日：2006-07-13

  A coating composition comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula: wherein X, R 1 , R 2 , p, m and n are described in the specification, or isomer or mixture of isomers thereof, two component compositions, articles coated with the novel composition and novel hydroxy amines are also part of the invention.

  一种包括以下成分的涂层组合物：a. 聚异氰酸酯交联剂；b. 具有至少一种化合物的异氰酸酯反应组分，其具有以下公式：其中X、R1、R2、p、m和n在说明书中有描述，或其异构体或异构体混合物，还包括双组分组合物、涂有新型组合物的物品和新型羟胺在内。
• Urea substituted benzothiazoles
  申请人：——

  公开号：US20040242576A1

  公开（公告）日：2004-12-02

  The present invention relates to compounds of formula I 1 wherein R 1 and R 2 are described herein, and their pharmaceutically acceptable salts thereof for the treatment of diseases, related to the A 2A receptor.

  本发明涉及式I1的化合物，其中R1和R2如本文所述，并且它们的药用可接受盐，用于治疗与A2A受体相关的疾病。