2-hydrazino-2'-deoxy-adenosine | 1000296-26-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-hydrazino-2'-deoxy-adenosine
• 英文别名: (2R,3S,5R)-5-(6-Amino-2-hydrazinyl-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol；(2R,3S,5R)-5-(6-amino-2-hydrazinylpurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
• CAS: 1000296-26-3
• 化学式: C₁₀H₁₅N₇O₃
• 分子量: 281.274
• InChiKey: PVBTZBGACFSXPR-KVQBGUIXSA-N

物化性质

• 沸点：
  754.9±70.0 °C(Predicted)
• 密度：
  2.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  157
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2-hydrazino-2'-deoxy-adenosine 在 溶剂黄146 、 sodium nitrite 作用下， 以 水 为溶剂， 生成 2-azidodeoxyadenosine
  参考文献：
  名称：

  Synthesis and Biological Evaluation of β-D-Pentofuranonucleoside Derivatives of 2-Azidoadenine and 6-Azidopurines

  摘要：

  beta-D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines have been synthesized. The azido-tetrazolo tautomerism observed on such nucleoside analogues has been studied. The compounds were tested for their activity against HIV and HBV but they did not show significant antiviral effect.

  DOI：

  10.1081/ncn-120021964
• 作为产物：
  描述：

  克拉屈滨 在 一水合肼 作用下， 生成 2-hydrazino-2'-deoxy-adenosine
  参考文献：
  名称：

  Synthesis and Biological Evaluation of β-D-Pentofuranonucleoside Derivatives of 2-Azidoadenine and 6-Azidopurines

  摘要：

  beta-D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines have been synthesized. The azido-tetrazolo tautomerism observed on such nucleoside analogues has been studied. The compounds were tested for their activity against HIV and HBV but they did not show significant antiviral effect.

  DOI：

  10.1081/ncn-120021964