strobochrysin | 529-52-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: strobochrysin
• 英文别名: 5,7-dihydroxy-6-methyl-2-phenylchromen-4-one
• CAS: 529-52-2
• 化学式: C₁₆H₁₂O₄
• 分子量: 268.269
• InChiKey: XRJWLVUOUWIPHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  strobochrysin 在 吡啶 、 potassium carbonate 、 丙酮 作用下， 生成 5-acetoxy-7-methoxy-6-methyl-2-phenyl-chromen-4-one
  参考文献：
  名称：

  Mukerjee; Seshadri, Proceedings - Indian Academy of Sciences, Section A, 1953, # 38, p. 207,217

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4,6-三羟基甲苯 在 盐酸 、 sodium benzoate 、 乙醚 、 zinc(II) chloride 作用下， 生成 strobochrysin
  参考文献：
  名称：

  Furukawa, Rikagaku Kenkyusho Iho, 1934, vol. 13, p. 1098,1104

  摘要：

  DOI：

文献信息

• COMPOSITION AND METHOD FOR TREATING OR PREVENTING INFLUENZA VIRUS INFECTION
  申请人：National Defense Medical Center

  公开号：US20150329515A1

  公开（公告）日：2015-11-19

  The present invention provides a pharmaceutical composition and method for treating or preventing influenza virus infection in a subject comprising administering the subject with a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of compounds provided in this invention. In addition, the prevent invention provides new compounds for treating or preventing influenza virus infection.

  本发明提供了一种治疗或预防流感病毒感染的药物组合物和方法，包括向受试者施用包含本发明提供的化合物的药物组合物，其中该药物组合物包括一种药用可接受载体和治疗有效量的化合物。此外，本发明还提供了用于治疗或预防流感病毒感染的新化合物。
• Structure determination of melanervin, the first naturally occurring flavonoid of the triphenylmethane family
  作者：O. Seligmann、H. Wagner

  DOI：10.1016/s0040-4020(01)98963-x

  日期：1981.1

  shown to be (2,4-dihydroxy-6-methoxy) tolyl-3-(5,7-dihydroxy-6-methyl) flavanonyl-8-phenylmethane, mainly by degradation, MS, 1H- and 13C-NMR-spectroscopy. The new flavanone represents the first naturally occurring triphenylmethane compound.

  从黄千层金合欢属植物中除黄烷酮司他波平和色氨酸之外，还分离出一种新的8-芳基-黄烷酮，并显示为（2,4-二羟基-6-甲氧基）甲苯基-3-（5,7-二羟基）。 -6-甲基）黄烷酰基-8-苯基甲烷，主要通过降解，MS，1 H-和13 C-NMR光谱分析。新的黄烷酮代表第一个天然存在的三苯甲烷化合物。
• Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases
  申请人：Gong Qiang Bang

  公开号：US20050049206A1

  公开（公告）日：2005-03-03

  In this invention, we describe a group of flavonoids and flavonoid-containing extracts that have pharmaceutical properties which are useful in the medicinal therapy of fibrotic diseases for the treatment or reparation and prevention of fibrotic lesional tissues. Representative flavonoids and flavonoid-containing extracts have the active compositions of the below formula. Those compositions can be extracted and purified from the botanicals, including Scutellaria baicalensis Georgi, Scutellaria scordifolia Fisch,Oroxylum indicum(L.) Vent, Plantago major L. The compositions of the invention are novel as an anti-fibrotic drugs, as agents for treating fibrosis.

  在这项发明中，我们描述了一组黄酮类化合物和含黄酮类化合物的提取物，具有药物特性，可用于治疗纤维化疾病的药物疗法，用于治疗、修复和预防纤维化病变组织。代表性的黄酮类化合物和含黄酮类化合物的提取物具有以下公式的活性成分。这些成分可以从植物中提取和纯化，包括黄芩、紫花地丁、橙黄木、车前草等。本发明的成分作为抗纤维化药物和治疗纤维化的药剂是新颖的。
• <i>C</i>-Isoprenylation of Flavonoids Enhances Binding Affinity toward P-Glycoprotein and Modulation of Cancer Cell Chemoresistance
  作者：Gilles Comte、Jean-Baptiste Daskiewicz、Christine Bayet、Gwenaëlle Conseil、Armelle Viornery-Vanier、Charles Dumontet、Attilio Di Pietro、Denis Barron

  DOI：10.1021/jm991128y

  日期：2001.3.1

  Previous studies have shown that flavones bind to P-glycoprotein (Pgp) with higher affinity than isoflavones, flavanones, and glycosylated derivatives. In the present work, a series of C- or O-substituted hydrophobic derivatives of chrysin were synthesized to further investigate structural requirements of the A ring toward Pgp modulation. Increasing hydrophobicity at either position 6, 8, or 7 increased the affinity of in vitro binding to a purified cytosolic domain of Pgp, but only benzyl and 3,3-dimethylallyl C-substitution produced a high maximal quenching of the protein intrinsic fluorescence. Inhibition of membrane Pgp within leukemic cells, characterized by intracellular drug accumulation, was specifically produced by isoprenylated derivatives, with 8-(3,3-dimethylallyl)chrysin being even more efficient than the commonly used cyclosporin A.
• Lindstedt; Misiorny, Acta Chemica Scandinavica (1947), 1951, vol. 5, p. 1,3
  作者：Lindstedt、Misiorny

  DOI：——

  日期：——