2,3-dihydrotrichostatin A | 1298085-51-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-dihydrotrichostatin A
• 英文别名: (E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohept-4-enamide
• CAS: 1298085-51-4
• 化学式: C₁₇H₂₄N₂O₃
• 分子量: 304.389
• InChiKey: ZTPXHRXMKLAVGG-XZHRJIJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  曲古柳菌素A 在 Streptomyces venezuelae YJ₀₂₈ 作用下， 反应 72.0h， 生成 2,3-dihydrotrichostatin A
  参考文献：
  名称：

  Microbial Transformation of Trichostatin A to 2,3-Dihydrotrichostatin A

  摘要：

  A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties.

  DOI：

  10.1021/np1006718

文献信息

• Compounds Useful in HIV Therapy
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：US20200299309A1

  公开（公告）日：2020-09-24

  The invention relates a compound of the formula: a pharmaceutically acceptable salt thereof, compositions thereof, and methods of therapeutic treatment using the same.