α-(4-isobutanoyl-3,5-di-tert-butylphenyl)-N-tert-butylnitrone | 273396-79-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-(4-isobutanoyl-3,5-di-tert-butylphenyl)-N-tert-butylnitrone
• 英文别名: alpha-(4-Isobutanoyl-3,5-di-tert-butylphenyl)-N-tert-butylnitrone；N-tert-butyl-1-[3,5-ditert-butyl-4-(2-methylpropanoyl)phenyl]methanimine oxide
• CAS: 273396-79-5
• 化学式: C₂₃H₃₇NO₂
• 分子量: 359.552
• InChiKey: XXKMBDZLLLZIFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-isobutanoyl-3,5-di-tert-butylbenzaldehyde 、 N-叔丁基羟胺 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 以50.8%的产率得到α-(4-isobutanoyl-3,5-di-tert-butylphenyl)-N-tert-butylnitrone
  参考文献：
  名称：

  3,4,5-trisubstituted aryl nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation

  摘要：

  揭示了3,4,5-三取代芳基亚硝基化合物及含有这种化合物的药物组合物。3,4,5-三取代芳基亚硝基化合物的化学式如下：其中R1-R4如规范中所定义。所披露的组合物可用作治疗哺乳动物炎症相关疾病，如关节炎，以及用作检测自由基的分析试剂。

  公开号：

  US06342523B1

文献信息

• 3,4,5-Trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
  申请人：RENOVIS, INC.

  公开号：US20040198835A1

  公开（公告）日：2004-10-07

  Disclosed are 3,4,5-trisubstituted aryl nitrone compoundsd and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R 1 -R 4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.

  本发明涉及3,4,5-三取代基芳基亚硝基化合物及含有此类化合物的医药组合物。3,4,5-三取代基芳基亚硝基化合物的化学式为(I)，其中R1-R4如规范中定义。所述组合物可用于哺乳动物的与炎症相关的疾病，例如关节炎等治疗，并可作为检测自由基的分析试剂。
• Use of aryl nitrone compounds in methods for treating neuropathic pain
  申请人：RENOVIS, INC.

  公开号：US20040209958A1

  公开（公告）日：2004-10-21

  3,4,5-trisubstituted aryl nitrone compounds having the formula: 1 where R 1 -R 4 are as defined in the specification are useful as therapeutics for neuropathic pain conditions in mammals.

  具有以下公式的3,4,5-三取代芳基亚硝基化合物：1其中R1-R4如规范所定义，对哺乳动物神经病痛症状有治疗作用。
• 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
  申请人：Renovis, Inc.

  公开号：US06998419B2

  公开（公告）日：2006-02-14

  Disclosed are 3,4,5-trisubstituted aryl nitrone compoundsd and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1–R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.

  本发明涉及3,4,5-三取代基芳基亚硝基化合物及包含此类化合物的药物组合物。3,4,5-三取代基芳基亚硝基化合物的化学式为(I)，其中R1-R4如规范中所定义。所披露的组合物可用作哺乳动物炎症相关疾病的治疗剂，如关节炎，并用作检测自由基的分析试剂。
• 3,4,5-trisubstituted aryl nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation
  申请人：Centaur Pharmaceuticals, Inc.

  公开号：US06342523B1

  公开（公告）日：2002-01-29

  Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have the formula: where R1-R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.

  揭示了3,4,5-三取代芳基亚硝基化合物及含有这种化合物的药物组合物。3,4,5-三取代芳基亚硝基化合物的化学式如下：其中R1-R4如规范中所定义。所披露的组合物可用作治疗哺乳动物炎症相关疾病，如关节炎，以及用作检测自由基的分析试剂。