1-O-(6-bromohexyl)-2,3-O-isopropylideneglycerol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-O-(6-bromohexyl)-2,3-O-isopropylideneglycerol
• 英文别名: 4-((6-bromohexyloxy)methyl)-2,2-dimethyl-1,3-dioxolane；4-(6-Bromohexoxymethyl)-2,2-dimethyl-1,3-dioxolane
• 化学式: C₁₂H₂₃BrO₃
• 分子量: 295.217
• InChiKey: WKNCLPKYRWHMAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-O-(6-bromohexyl)-2,3-O-isopropylideneglycerol 在 吡啶 、 4-二甲氨基吡啶 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 水 、 甲苯 、 苯 为溶剂， 反应 16.0h， 生成 1-(6-((2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methoxy)hexyl)-1,4,8,11-tetraazacyclotetradecane
  参考文献：
  名称：

  Synthesis and characterization of monomeric and polymeric Cu(II) complexes of 3,4-ethylenedioxythiophene-functionalized with cyclam ligand

  摘要：

  A functionalized EDOT derivative with 1,4,8,11-tetraazacyclotetradecane (cyclam) ligand pendant to the ethylene bridge (4) and its complexes [M(4)(BF4)(2)], where M(II)=Cu(II), was prepared and characterized. Their electrochemical copolymerization with EDOT was studied. The electro-co-polymerized films were characterized by electrochemical methods, X-ray photoelectron spectroscopy and by X-ray fluorescence spectroscopy. The co-polymerization method was found to afford a good control of the metal concentration in the polymer matrix and represents a good technique for preparing electronically conductive polymers containing redox-active metal complexes. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.electacta.2010.08.075
• 作为产物：
  描述：

  1,6-二溴己烷 、 丙酮缩甘油 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 12.33h， 以73%的产率得到1-O-(6-bromohexyl)-2,3-O-isopropylideneglycerol
  参考文献：
  名称：

  Synthesis and characterization of monomeric and polymeric Pd(II) and Pt(II) complexes of 3,4-ethylenedioxythiophene-functionalized phosphine ligands

  摘要：

  我们制备了带有 3,4-亚乙二氧基噻吩（EDOT）基团的膦配体及其顺式[MCl2(L)2]（M = Pd 和 Pt）络合物，其中 Ph2P 基团与噻吩环[Ph2P(5-EDOT), 1]直接相连，或通过亚甲基（4）或长（7）"间隔物 "与 EDOT 乙烯桥相连。研究人员对这些络合物与 EDOT 的电化学共聚进行了研究，以期制造出含有共价结合金属膦络合物的导电聚合物。虽然在所有实验中都获得了聚合物涂层电极，但 XPS 测量结果表明，在存在顺式-[MCl2(1)2] 的情况下制成的聚合物仅由聚(3,4-亚乙二氧基噻吩)（PEDOT）组成，而在存在顺式-[MCl2(L)2] （L = 4，7）的情况下制成的聚合物则是真正的共聚物，其中含有钯（II）或铂（II）络合物。

  DOI：

  10.1039/b817210b

文献信息

• Synthesis and characterization of monomeric and polymeric Pd(II) and Pt(II) complexes of 3,4-ethylenedioxythiophene-functionalized phosphine ligands
  作者：Kuhamoorthy Velauthamurty、Simon J. Higgins、R. M. Gamini Rajapakse、John Bacsa、Harm van Zalinge、Richard J. Nichols、Wolfgang Haiss

  DOI：10.1039/b817210b

  日期：——

  Phosphine ligands bearing 3,4-ethylenedioxythiophene (EDOT) groups, in which a Ph2P group is either connected directly to the thiophene ring [Ph2P(5–EDOT), 1] or to the EDOT ethylene bridge via a methylene (4) or longer (7) ‘spacer’, have been prepared, together with their complexes cis-[MCl2(L)2] (M = Pd and Pt). The electrochemical co-polymerization of the complexes with EDOT was investigated, with a view to making conducting polymers incorporating covalently-bound metal–phosphine complexes. Although polymer-coated electrodes were obtained in all experiments, XPS measurements established that polymers made in the presence of cis-[MCl2(1)2] consisted only of poly(3,4-ethylenedioxythiophene) (PEDOT), whereas polymers made in the presence of cis-[MCl2(L)2] (L = 4, 7) were genuine co-polymers containing Pd(II) or Pt(II) complexes.

  我们制备了带有 3,4-亚乙二氧基噻吩（EDOT）基团的膦配体及其顺式[MCl2(L)2]（M = Pd 和 Pt）络合物，其中 Ph2P 基团与噻吩环[Ph2P(5-EDOT), 1]直接相连，或通过亚甲基（4）或长（7）"间隔物 "与 EDOT 乙烯桥相连。研究人员对这些络合物与 EDOT 的电化学共聚进行了研究，以期制造出含有共价结合金属膦络合物的导电聚合物。虽然在所有实验中都获得了聚合物涂层电极，但 XPS 测量结果表明，在存在顺式-[MCl2(1)2] 的情况下制成的聚合物仅由聚(3,4-亚乙二氧基噻吩)（PEDOT）组成，而在存在顺式-[MCl2(L)2] （L = 4，7）的情况下制成的聚合物则是真正的共聚物，其中含有钯（II）或铂（II）络合物。
• Synthesis of Alkyl Chain-Modified Ether Lipids and Evaluation of Their in Vitro Cytotoxicity
  作者：Empar Fos、Nuria Suesa、Liset Borras、Cinta Lobato、Patrizia Banfi、Romolo A. Gambetta、Franco Zunino、David Mauleon、Germano Carganico

  DOI：10.1021/jm00007a018

  日期：1995.3

  A series of alkyl lysophospholipid (ALP) analogs of ET-18-OCH3 (1-O-octadecyl-2-O-methylrac-glycero-3-phosphocholine) containing modifications in the long C-1 chain has been synthesized and evaluated in human tumor cell line cytotoxicity assays. The compounds have also been evaluated in platelet activating factor (PAF) receptor agonism and hemolysis tests. Two modifications have been studied, introduction of a carbonyl group at different positions of the C-1 chain and branching of this chain, in some compounds with incorporation of a phenyl group. Several compounds showed a cytotoxic potency comparable to that of the reference compound ET-18-OCH3, associated with reduced proaggregating and hemolytic effects. The two enantiomers of 1-0-(7-oxooctadecyl)-2-O-methyl-rac-glycero-3-phospho choline (2) showed the same level of cytotoxicity or antiproliferative activity, with the PAF-agonistic effect confined to R-2. The very low stereoselectivity found in the in vitro cytotoxicity confirms earlier results and indicates a lack of stereospecific interactions with a macromolecular target.
• [EN] KETOALKYLGLYCEROPHOSPHOLIPIDS HAVING ANTITUMOR AND ANTI-PLATELET AGGREGATION ACTIVITIES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS THEREFROM
  申请人：LABORATORIOS MENARINI S.A.

  公开号：WO1993001196A1

  公开（公告）日：1993-01-21

  (EN) Compounds of general formula (I) wherein R1 is a C1-C16 straight or branched alkyl group, a phenyl group or a phenyl-C6-C16alkyl group; n is an integer from 3 to 18, inclusive; R2 is a C1-C12 straight or branched alkyl group; R3 is hydrogen, a carboxy, alkoxycarbonyl, arylalkoxycarbonyl or aryloxycarbonyl group of less than 12 carbon atoms in the last three cases; R4, R5 and R6, which can be the same or different, are hydrogen, a C1-C6 alkyl group or N+R4R5R6 is a cyclic ammonium group, which can be aromatic or non-aromatic, wherein two of the R4, R5 or R6 groups form a ring together with the nitrogen atom, and the other group is hydrogen or C1-C6 alkyl, have antitumor and anti-platelet aggregating activities.(FR) L'invention se rapporte à des composés représentés par la formule générale (I), où R1 représente un groupe alkyle droit ou ramifié C1-C16, un groupe phényle ou un groupe phényle-alkyle C6-C16; n représente un nombre entier compris entre 3 et 18, inclus; R2 représente un groupe alkyle droit ou ramifié C1-C12; R3 représente de l'hydrogène, un groupe carboxy, alcoxycarbonyle, arylalcoxycarbonyle ou aryloxycarbonyle ayant moins de 12 atomes de carbone dans les trois derniers cas; R4, R5 et R6 qui peuvent être identiques ou différents, représentent de l'hydrogène, un groupe alkyle C1-C6, ou N+R4R5R6 représente un groupe d'ammonium cyclique, qui peut être aromatique ou non aromatique, dans lequel deux des groupes R4, R5 ou R6 forment une chaîne fermée avec l'atome d'azote, et l'autre groupe représente hydrogène ou alkyle C1-C6. Ces composés ont des propriétés telles qu'ils peuvent être utilisés comme agents antitumoraux et comme antiagrégants plaquettaires.
• Synthesis and characterization of monomeric and polymeric Cu(II) complexes of 3,4-ethylenedioxythiophene-functionalized with cyclam ligand
  作者：Kuhamoorthy Velauthamurty、Simon J. Higgins、R.M. Gamini Rajapakse、H.M.N. Bandara、Masaru Shimomura

  DOI：10.1016/j.electacta.2010.08.075

  日期：2010.12

  A functionalized EDOT derivative with 1,4,8,11-tetraazacyclotetradecane (cyclam) ligand pendant to the ethylene bridge (4) and its complexes [M(4)(BF4)(2)], where M(II)=Cu(II), was prepared and characterized. Their electrochemical copolymerization with EDOT was studied. The electro-co-polymerized films were characterized by electrochemical methods, X-ray photoelectron spectroscopy and by X-ray fluorescence spectroscopy. The co-polymerization method was found to afford a good control of the metal concentration in the polymer matrix and represents a good technique for preparing electronically conductive polymers containing redox-active metal complexes. (C) 2010 Elsevier Ltd. All rights reserved.