Benzyl-DOPA-NH-Boc-COOCH2CH2OH | 913259-53-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Benzyl-DOPA-NH-Boc-COOCH2CH2OH
• 英文别名: Boc-Phe(3,4-diOBn)-OGly-ol；2-hydroxyethyl (2S)-3-[3,4-bis(phenylmethoxy)phenyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
• CAS: 913259-53-7
• 化学式: C₃₀H₃₅NO₇
• 分子量: 521.61
• InChiKey: GARVDBZEWOPAOG-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  38
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Benzyl-DOPA-NH-Boc-COOCH2CH2OH 、 丁二酸酐 在 吡啶 作用下， 反应 18.0h， 以68%的产率得到Benzyl-DOPA-NH-Boc-linker
  参考文献：
  名称：

  Synthesis and Characterization of Water-Soluble and Photostable L-DOPA Dendrimers

  摘要：

  A small drug molecule, L-DOPA, was converted into well-defined dendritic macromolecules. Their monodisperse nature was shown by NMR, MALDI-TOF-MS, and PAGE. A third-generation L-Dopa dendrimer contained 30 L-Dopa residues, which made up its core, branches, and periphery. Individual L-Dopa moieties in the dendrimer were connected to one another via hydrolyzable diester linkages. These Dopa dendrimers showed a 20-fold increase in aqueous solubility and enhanced photostability in solutions over L-Dopa under identical conditions.

  DOI：

  10.1021/ol061449l
• 作为产物：
  描述：

  N-BOC-3-羟基-L-酪氨酸甲酯 在 sodium hydroxide 、 potassium carbonate 、 N,N'-二环己基碳二亚胺 、 DPTS 、 sodium iodide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 、 丙酮 为溶剂， 反应 30.0h， 生成 Benzyl-DOPA-NH-Boc-COOCH2CH2OH
  参考文献：
  名称：

  Synthesis and Characterization of Water-Soluble and Photostable L-DOPA Dendrimers

  摘要：

  A small drug molecule, L-DOPA, was converted into well-defined dendritic macromolecules. Their monodisperse nature was shown by NMR, MALDI-TOF-MS, and PAGE. A third-generation L-Dopa dendrimer contained 30 L-Dopa residues, which made up its core, branches, and periphery. Individual L-Dopa moieties in the dendrimer were connected to one another via hydrolyzable diester linkages. These Dopa dendrimers showed a 20-fold increase in aqueous solubility and enhanced photostability in solutions over L-Dopa under identical conditions.

  DOI：

  10.1021/ol061449l

文献信息

• WO2007/87256
  申请人：——

  公开号：——

  公开（公告）日：——
• Synthesis and Characterization of Water-Soluble and Photostable L-DOPA Dendrimers
  作者：Shengzhuang Tang、Lynda J. Martinez、Ajit Sharma、Minghui Chai

  DOI：10.1021/ol061449l

  日期：2006.9.1

  A small drug molecule, L-DOPA, was converted into well-defined dendritic macromolecules. Their monodisperse nature was shown by NMR, MALDI-TOF-MS, and PAGE. A third-generation L-Dopa dendrimer contained 30 L-Dopa residues, which made up its core, branches, and periphery. Individual L-Dopa moieties in the dendrimer were connected to one another via hydrolyzable diester linkages. These Dopa dendrimers showed a 20-fold increase in aqueous solubility and enhanced photostability in solutions over L-Dopa under identical conditions.