DPTS

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: DPTS
• 英文别名: 4-(dimethylamino)pyridinium 4-toluenesulfonate；4-(dimethylamino)pyridinium p-toluenesulfonate；4-(N,N-dimethylamino)pyridinium-4-toluene sulfonate；4-(dimethylamino)pyridinium tosylate；4-(N,N-dimethylamino)pyridinium p-toluenesulfonate；N,N-dimethyl-4-aminopyridinium p-toluenesulfonate；4-(dimethylamino)pyridinium toluene-p-sulfonate；4-dimethylaminopyridine p-toluenesulfonate；4-dimethylaminopyridine tosylate；PTSA-DMAP；N,N-Dimethylpyridin-4-amine 4-methylbenzenesulfonate；N,N-dimethylpyridin-4-amine;4-methylbenzenesulfonic acid
• 化学式: C₇H₈O₃S*C₇H₁₀N₂
• 分子量: 294.375
• InChiKey: OAOSXODRWGDDCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.76
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  82.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  罗丹明B 、 2-[2-(2-叠氮基乙氧基)乙氧基]乙醇 、 DPTS 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以93%的产率得到
  参考文献：
  名称：

  氟化、氢化和杂化 Janus 树枝状聚合物的自分类和共组装成树枝状聚合物

  摘要：

  报告了包含七个自组装两亲 Janus 树枝状聚合物的库的模块化合成。其中三个分子在其疏水部分 (RF) 中含有环保的手性-外消旋氟化树突，一个包含非手性氢化树突​​ (RH)，而一种称为混合 Janus 树枝状大分子，包含手性-外消旋氟化和非手性氢化树突​​ (RHF) 的组合) 在其疏水部分。两个 Janus 树枝状聚合物包含手性外消旋氟化树枝状分子和与其亲水部分 (RF-NBD) 共轭的绿色荧光染料，或在其亲水部分 (RH-RhB) 中包含非手性氢化和红色荧光染料。这些 RF、RH 和 RHF Janus 树枝状大分子自组装成单层或洋葱状软泡状树枝状体 (DSs)，通过简单地将乙醇溶液注入水或缓冲液中，可以获得与生物膜厚度相似的膜。由于 RF 和 RH 树突不混溶，RF-NBD 和 RH-RhB 被用于通过荧光显微镜研究 RF 和 RH 以及磷脂的自分选和共组装成混合 DSs 由混合氢化氟化

  DOI：

  10.1021/jacs.6b08069
• 作为产物：
  描述：

  [tributyl(methylselanyl)-λ5-phosphanyl] 4-methylbenzenesulfonate 以100%的产率得到
  参考文献：
  名称：

  HAYNES, R. K.;INDORATO, C., AUSTRAL. J. CHEM., 1984, 37, N 6, 1183-1194

  摘要：

  DOI：
• 作为试剂：
  描述：

  、 在 DPTS 、 N,N'-二异丙基碳二亚胺 作用下， 以 氯仿 为溶剂， 以66 %的产率得到
  参考文献：
  名称：

  10.1002/cplu.202400320

  摘要：

  Multifluorinated aromatics serve as supramolecular synthons in the research of organic electro‐optic (EO) materials by exploiting π−π stacking interaction between the aromatic hydrocarbon and multifluorinated aromatic groups for performance improvement. However, non‐classical hydrogen bonding remains largely unexplored in fluorinated EO dendrimers. In this study, three Fréchet‐type generation 1 benzyl ether co‐dendrons were synthesized by replacing one benzyl group with 2,3,5,6‐tetrafluorobenzyl (p‐HF4Bz), pentafluorobenzyl (C6F5Bz), and 2,3,4,5‐tetrafluorobenzyl (o‐HF4Bz) groups, to afford the benzoic acid derivatives D1, D2, and D3, which were further bonded to the donor and π‐bridge moieties to afford three co‐dendronized push‐pull phenyltetraene chromophores EOD1, EOD2, and EOD3, respectively. The weak C−H⋅⋅⋅X (X = O, F) interactions in the crystal structure of D1 cumulatively add to the benzoic acid dimers to form an extended hydrogen‐bonded network, while D2 is crystallized into a centric one‐dimensional chain with strong intermolecular interactions. The poled films of EOD1 with PMMA exhibited the largest and most stable EO activity with optical homogeneity among the series. The results identify the effectiveness of weak but favorable hydrogen bonds enabled by the enhanced carbon acidity of p‐HF4Bz synthon in D1, over the interactions in D2 and D3, for the rational design of supramolecular EO dendrimers.

  DOI：

  10.1002/cplu.202400320

文献信息

• [EN] MODULAR SYNTHESIS OF AMPHIPHILIC JANUS GLYCODENDRIMERS AND THEIR SELF-ASSEMBLY INTO GLYCODENDRIMERSOMES<br/>[FR] SYNTHÈSE MODULAIRE DE GLYCODENDRIMÈRES AMPHIPHILES DE TYPE JANUS ET LEUR AUTOASSEMBLAGE EN GLYCODENDRIMÈRESOMES
  申请人：PERCEC VIRGIL

  公开号：WO2014190024A1

  公开（公告）日：2014-11-27

  The invention concerns compounds of the formula (I) wherein: Y1 and Y2 are independently a monosaccharide or disaccharide; X1 and X2 are independently -(R9-O)m-, -(R10)P-, -O-(R11-O)q-, -R16-O-R17-O- or a covalent bond; Q1 and Q2 are independently a nitrogen-containing heterocycle moiety; Z1 and Z2 are independently -(O-R7)-, -(O-C(=O)-R8)a-, -O-C(=O)-R12-C(=0)-R13-, -O- C(=O)-R14-C(=O)-R15 or a covalent bond; R7-R17 are each independently C1-C6 alkyl; R1-R6 are each independently a linear or branched alkly group; b, c, d, e, f, and g are 0 or 1, provided b + c + d equals at least 2 and e + f + g equals at least 2; and a, m, p, and q are each an integer from 1-6.

  该发明涉及式(I)的化合物，其中：Y1和Y2分别是单糖或二糖；X1和X2分别是-(R9-O)m-，-(R10)P-，-O-(R11-O)q-，-R16-O-R17-O-或共价键；Q1和Q2分别是含氮杂环基；Z1和Z2分别是-(O-R7)-，-(O-C(=O)-R8)a-，-O-C(=O)-R12-C(=0)-R13-，-O- C(=O)-R14-C(=O)-R15或共价键；R7-R17各自独立地是C1-C6烷基；R1-R6各自独立地是线性或支链烷基；b、c、d、e、f和g为0或1，但要求b + c + d至少等于2，e + f + g至少等于2；a、m、p和q各自是1-6的整数。
• OLIGOMER-CONTAINED NANOPARTICLE COMPLEX RELEASE SYSTEM
  申请人：National Yang Ming University

  公开号：US20140363490A1

  公开（公告）日：2014-12-11

  An oligomer-contained nanoparticle complex is provided. The oligomer-contained nanoparticle complex of the invention comprises (a) a nanoparticle, (b) a polymer with high molecule weigh, (c) a target molecule, (d) an oligomer, wherein the oligomer is crosslinked with the polymer by the intermolecular hydrogen bonds or electron bonds, and e) a space for active substances, wherein the space for active substances is encapsulated by the nanoparticle. The oligomer-contained nanoparticle complex of the invention has the high stability and fast drug release rate, and would not be largely accumulated in normal tissues. The invention also provides a method for preparing the oligomer-contained nanoparticle complex and the method for releasing drug.

  本发明提供了一种含有寡聚物的纳米颗粒复合物。该发明中的含有寡聚物的纳米颗粒复合物包括：(a)一种纳米颗粒，(b)一种高分子量聚合物，(c)一种目标分子，(d)一种寡聚物，其中寡聚物通过分子间氢键或电子键与聚合物交联，以及(e)一种活性物质的空间，其中活性物质的空间被纳米颗粒封装。本发明的含有寡聚物的纳米颗粒复合物具有高稳定性和快速释药率，并且不会在正常组织中大量积累。本发明还提供了制备含有寡聚物的纳米颗粒复合物的方法以及释药方法。
• BIO-INSPIRED AND ANTIMICROBIAL POLYMERS CONTAINING AMINO ACID-LIKE MONOMER BUILDING BLOCKS
  申请人：Joy Abraham

  公开号：US20170172147A1

  公开（公告）日：2017-06-22

  Methods for killing a microbial are provided that include introducing a functionalized amide polymer to a microbe, where the functionalized amide polymer includes a polymer backbone selected from polyesters and polyurethanes; an amide group with a pendant functional group, where the nitrogen atom of the amide group is part of the polymer backbone; and a net positive charge.

  提供了一种杀灭微生物的方法，包括向微生物引入一个功能化酰胺聚合物，其中该功能化酰胺聚合物包括从聚酯和聚氨酯中选择的聚合物骨架；一个带有挂链功能基团的酰胺基团，其中酰胺基团的氮原子是聚合物骨架的一部分；以及净正电荷。
• MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF TAXANE-BASED COMPOUNDS
  申请人：Nektar Therapeutics

  公开号：US20160235705A1

  公开（公告）日：2016-08-18

  Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the taxane-based compound is achieved.

  在其他方面，本文提供了紫杉醇类化合物和/或其氟化形式的多臂聚合物前药共轭物。还提供了制备这种共轭物的方法以及给药的方法。在给患者施用后，紫杉醇类化合物被释放。
• [EN] POLYDENDRONS<br/>[FR] POLYDENDRONS
  申请人：UNIV LIVERPOOL

  公开号：WO2014199174A1

  公开（公告）日：2014-12-18

  A method of preparing a non-gelled branched vinyl polymer scaffold carrying dendrons, comprising the living or controlled polymerization of a monofunctional vinyl monomer and a difunctional vinyl monomer, using a dendron initiator and at least one further initiator.

  一种制备携带树枝状分子的非凝胶化支化乙烯聚合物支架的方法，包括对单官能乙烯单体和双官能乙烯单体进行活性或受控聚合，使用树枝状引发剂和至少一种进一步引发剂。