4-(十六烷氧基)苯甲醛 | 59117-18-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-(十六烷氧基)苯甲醛
• 英文名称: p-n-hexadecyloxybenzaldehyde
• 英文别名: 4-hexadecyloxybenzaldehyde；4-n-hexadecyloxy benzaldehyde；p-hexadecyloxybenzaldehyde；4-hexadecoxybenzaldehyde
• CAS: 59117-18-9
• 化学式: C₂₃H₃₈O₂
• mdl: MFCD00021073
• 分子量: 346.554
• InChiKey: VOJUFZIYRURGFZ-UHFFFAOYSA-N

物化性质

• 熔点：
  44 °C(Solv: methanol (67-56-1))
• 沸点：
  461.6±18.0 °C(Predicted)
• 密度：
  0.929±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  25
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(十六烷氧基)苯甲醛 生成 4-hexadecyloxycinnamoyl chloride
  参考文献：
  名称：

  Lohar, J. M.; Mahsru, Urvashi, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1981, vol. 20, # 2, p. 125 - 128

  摘要：

  DOI：
• 作为产物：
  描述：

  对羟基苯甲醛 在 halohexadecane 作用下， 以 丙酮 为溶剂， 生成 4-(十六烷氧基)苯甲醛
  参考文献：
  名称：

  几何形状和分子刚性对介晶性的影响

  摘要：

  摘要 一个新的非线性同源系列 RO-C6H4-CH˭CH-COO-C6H4 (meta) ‒CO-CH˭CH-C6H4-OC12H25(n) (para) 由三个苯环和两个中心桥 ‒CH˭CH- 组成COO- 和-CO-CH˭CH- 以及-OR 和-OC12H25(n) 分别作为柔性和恒定末端基团。目标旨在了解和建立分子结构对非线性倒“V”形分子的液晶特性的影响。小说同源系列由十三个同源组成。通过配备加热台的偏振光学显微镜 (POM) 确定转变温度和纹理。向列相的纹理为螺纹或纹影，近晶相的纹理为A型或C型。相图的过渡曲线以正常方式表现。Sm-N 和 NI 过渡曲线表现出奇偶效应。分析，

  DOI：

  10.1080/15421406.2016.1190509

文献信息

• The effect of position of <i>tert</i>-butyl tail group on the formation of liquid crystal in Schiff base ester based homologous series
  作者：V. S. Sharma、R. B. Patel

  DOI：10.1080/15421406.2017.1283886

  日期：2017.5.3

  ABSTRACT We report a newly rod like calamatic liquid crystalline materials, which are constructed by the self-organization of a rod-like carboxylic acid derivative based on Schiff base ester as the linking group with tert butyl tail group. A newly series of 4-(tert-butyl) phenyl 4-((4-alkoxybenzylidene) amino) benzoate with different alkyl chain spacer (n = 1 to 8, 10, 12, 14, 16, and 18) were synthesized

  图形摘要摘要我们报告了一种新的棒状光滑液晶材料，它是由基于席夫碱酯作为连接基团的棒状羧酸衍生物与叔丁基尾基团自组装构成的。合成了具有不同烷基链间隔物（n = 1 到 8、10、12、14、16 和 18）的新系列 4-（叔丁基）苯基 4-（（4-烷氧基亚苄基）氨基）苯甲酸酯及其通过差示扫描量热法和偏光显微镜研究了介晶性质。本系列中的所有同源物均以对映方式显示中间相。SmC-SmA 的热稳定性为 137.5 °C。所有化合物均通过光谱和元素分析表征。
• Studies on antidiabetic agents. III. 5-Arylthiazolidine-2,4-diones as potent aldose reductase inhibitors.
  作者：TAKASHI SOHDA、KATSUTOSHI MIZUNO、EIKO IMAMIYA、HIROYUKI TAWADA、KANJI MEGURO、YUTAKA KAWAMATSU、YUJIRO YAMAMOTO

  DOI：10.1248/cpb.30.3601

  日期：——

  Thiazolidine-2, 4-dione derivatives having one or two substituent (s) such as phenyl, heteryl and alkyl group (s) at the 5-position were synthesized and evaluated as aldose reductase inhibitors. Inhibition by the active compounds of the swelling of the lens in a rat-lens-culture assay was also measured. Among these compounds, a series of 5-(3, 4-dialkoxyphenyl) thiazolidine-2, 4-diones showed pronounced activities in both assays. Structure-activity relationships are discussed and a new approach to the synthesis of 5-arylthiazolidine-2, 4-diones is described.

  具有一个或两个取代基（如苯基、杂基和烷基）的噻唑烷-2,4-二酮衍生物在5位合成并评估为醛糖还原酶抑制剂。在鼠晶状体培养检测中，活性化合物的抑制作用也被测量。在这些化合物中，一系列5-(3,4-二烷氧基苯基)噻唑烷-2,4-二酮在两种检测中显示出显著的活性。结构-活性关系进行了讨论，并描述了一种合成5-芳基噻唑烷-2,4-二酮的新方法。
• Tuning the thermotropic properties of liquid crystalline p-substituted aroylhydrazones
  作者：Hemant Kumar Singh、Sachin Kumar Singh、Rajib Nandi、Madan Kumar Singh、Vijay Kumar、Ranjan K. Singh、D. S. Shankar Rao、S. Krishna Prasad、Bachcha Singh

  DOI：10.1039/c5ra06620d

  日期：——

  Lamellar smectic A to columnar mesophase crossover is observed in p-substituted aroylhydrazones by variation of the alkoxy chain density at peripherals.

  通过改变周边烷氧链密度，在p-取代芳酰肼中观察到片层烟酸A到柱状介晶相的交叉。
• Synthesis and properties ofN-[1-hydroxyimino-2-methyl-1-(2-pyridyl)prop-2-yl]hydroxylamine and heterocyclic derivatives based on it
  作者：M. A. Voinov、L. B. Volodarsky

  DOI：10.1007/bf02495361

  日期：1997.1

  N-[1-Hydroxyimino-2-methyl-1-(2-pyridyl)prop-2-yl]hydroxylamine, a new representative of the series of α-hydroxylamino oximes, was synthesized. Based on this compounds, 3-imidazoline 3-oxide and 2-imidazoline 3-oxide derivatives, were obtained, and some of their chemical properties were investigated.

  合成了 N-[1-Hydroxyimino-2-methyl-1-(2-pyridyl)prop-2-yl] 羟胺，这是 α-羟氨基肟系列的新代表。在此基础上，获得了3-咪唑啉3-氧化物和2-咪唑啉3-氧化物衍生物，并研究了它们的一些化学性质。
• Multicolor fluorescent switches in gel systems controlled by alkoxyl chain and solvent
  作者：Yue Xu、Pengchong Xue、Defang Xu、Xiaofei Zhang、Xingliang Liu、Huipeng Zhou、Junhui Jia、Xinchun Yang、Fengyong Wang、Ran Lu

  DOI：10.1039/c0ob00091d

  日期：——

  Two simple molecules, 1 and 2 with D-π-A structure and alkoxyl groups, respectively, were designed and synthesized. Both compounds can gelatinize THF–water and DMSO. And compound 2 forms gel in acetone by ultrasonic stimulus. Interestingly, these gels exhibit aggregation-induced emission (AIE) during the sol–gel phase transformation. Moreover, the molecular self-assembled and photophysical properties can be controlled by the number of the alkoxyl chains and the type of the solvents. For example, 1 has an identical packing model and fluorescent colour in THF–water and DMSO gels. Contrarily, the self-assembly of molecule 2 strongly depends on the solvent. Furthermore, the gel phases of 2 formed in three solvents possess different fluorescent colours. Such as, THF–water gel emits yellow fluorescence, acetone gel has orange emission and red fluorescence appears in DMSO.

  设计并合成了两种简单的D-π-A结构和烷氧基的分子1和2。这两种化合物均能凝胶化四氢呋喃-水和二甲基亚砜。而且，通过超声刺激，化合物2可以在丙酮中形成凝胶。有趣的是，这些凝胶在溶胶-凝胶相转变过程中表现出聚集诱导发光（AIE）现象。此外，分子自组装和光物理性质可以通过烷氧基链的数量和溶剂类型进行调控。例如，1在四氢呋喃-水凝胶和二甲基亚砜凝胶中具有相同的堆积模型和荧光颜色。相反，分子2的自组装强烈依赖于溶剂。此外，2在三种溶剂中形成的凝胶相具有不同的荧光颜色。例如，四氢呋喃-水凝胶发出黄色荧光，丙酮凝胶有橙色发射，而二甲基亚砜中则出现红色荧光。