1-methoxycarbonyl-2-methyl-cyclopent-1-ene | 25662-30-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-methoxycarbonyl-2-methyl-cyclopent-1-ene
• 英文别名: 1-carbomethoxy-2-methylcyclopentene；Methyl-2-methyl-1-cyclopenten-1-carboxylat；2-Methylcyclohexencarbonsaeuremethylester；2-Methylcyclopenten-1-carbonsaeuremethylester；2-methyl-cyclopent-1-enecarboxylic acid methyl ester；2-Methyl-cyclopent-1-encarbonsaeure-methylester；Methyl 2-methyl-1-cyclopentene-1-carboxylate；methyl 2-methylcyclopentene-1-carboxylate
• CAS: 25662-30-0
• 化学式: C₈H₁₂O₂
• 分子量: 140.182
• InChiKey: FJEGEQZRLGQSGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methoxycarbonyl-2-methyl-cyclopent-1-ene 在 对甲苯磺酸 作用下， 以 甲醇 、 苯 为溶剂， 生成
  参考文献：
  名称：

  使用自由基裂解方法合成倍半萜三氯二烯

  摘要：

  据报道，倍半萜三甲双烯具有高度的区域选择性和立体选择性。该方法仅需9个步骤，即从[2 + 2]光加成反应开始，并且在关键步骤中采用了“外部”环丁烷键的自由基断裂。

  DOI：

  10.1016/s0040-4039(98)01140-x
• 作为产物：
  描述：

  dimethyl 4-pentenylmalonate 在 Pd(dppe) 、 potassium tert-butylate 作用下， 生成 1-methoxycarbonyl-2-methyl-cyclopent-1-ene
  参考文献：
  名称：

  Formation de derives cyclopentaniques assistee par une espece hydrure de palladium : Aspects synthetiques et mecanisme

  摘要：

  In the presence of a palladium(0) complex and potassium t-butoxide, the acetylenic compounds 2 bearing in delta a nucleophilic functionality are smoothly transformed with excellent yields, either into 2,2-difunctionalized methylene cyclopentanes or into monofunctionalized 2-methylcyclopentenes. Each of these compounds can be specifically obtained depending on the choice of the experimental conditions.A set of diverse reactions involving mainly potassium hydride as the base showed clearly that HPdOtBu is not the active catalytic species which is mainly a sigma-ethynylpalladium hydride formed by the metal insertion in the acetylenic carbon hydrogen bond.

  DOI：

  10.1016/s0040-4020(01)89040-2

文献信息

• General Zinc-Catalyzed Conia-Ene Reactions of 1,3-Dicarbonyl Compounds with Alkynes Including the Classically Challenging Substrates under Neat Conditions
  作者：Chen-Liang Deng、Ren-Jie Song、Yi-Lin Liu、Jin-Heng Li

  DOI：10.1002/adsc.200900588

  日期：2009.12

  products has been developed by zinc-catalyzed intramolecular Conia-ene reactions of 1,3-dicarbonyl compounds with alkynes. This new route allows a wide range of dicarbonyl compounds, including the classically challenging 1,3-diesters and N,N′-disubstituted 1,3-keto amides, to be used for the Conia-ene reaction with inexpensive zinc chloride (ZnCl2) under neat conditions.

  通过锌催化1,3-二羰基化合物与炔烃的分子内Conia-ene反应，已经开发出一种简单的，多用途的新方法，可将四元环变成六元环。这种新途径允许将广泛的二羰基化合物，包括经典的具有挑战性的1,3-二酯和N，N'-二取代的1,3-酮酰胺，用于与廉价氯化锌（ZnCl 2）。
• Nuclear synthons: mesyltriflone as an olefin polyanion equivalent
  作者：James B. Hendrickson、Gerald J. Boudreaux、Paul S. Palumbo

  DOI：10.1021/ja00269a037

  日期：1986.4

  then of Ramberg-Backlund elimination to a substituted olefin. The alkylations are clean and regiospecific, often amenable to one-pot operation, and in most cases the elimination is smooth. A variety of examples is presented to establish the scope of the method, and the mechanism and stereochemistry are discussed. Nuclear Synthons. In our examination of the logic of synthesis design* we directed attention

  甲磺酰三氟乙烯 (CF3S02CH2S02CH3) 被开发为一种核合成试剂，能够首先进行多种结构，例如烷基化，然后通过 Ramberg-Backlund 消除生成取代的烯烃。烷基化是干净的和区域特异性的，通常适合一锅法操作，并且在大多数情况下消除是顺利的。提供了各种示例来确定该方法的范围，并讨论了机理和立体化学。核合成器。在我们对合成设计*逻辑的检查中，我们将注意力集中在最小化步骤和主要利用构建反应的核心重要性上。这些想法的一个主要推论是多重构造的首要重要性，允许在一次操作中进行两个或更多构造。等式 1-4 中说明了该概念的典型示例，
• NOVEL TRICYCLIC PROTEIN KINASE MODULATORS
  申请人：HADDACH Mustapha

  公开号：US20110071136A1

  公开（公告）日：2011-03-24

  The invention provides compounds that inhibit CK2 and/or Pim kinases and compositions containing such compounds. These tricyclic compounds and compositions containing them are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, pathogenic infections, and certain immunological disorders.

  这项发明提供了抑制CK2和/或Pim激酶的化合物以及含有这些化合物的组合物。这些三环化合物和含有它们的组合物对于治疗增殖性疾病如癌症以及其他与激酶相关的疾病条件包括炎症、疼痛、病原体感染和某些免疫性疾病是有用的。
• Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
  申请人：Coburn A. Craig

  公开号：US20070021454A1

  公开（公告）日：2007-01-25

  The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及式（I）及其互变异构体的螺环吡啶化合物，这些化合物是β-分泌酶酶的抑制剂，并且在治疗β-分泌酶酶参与的疾病，如阿尔茨海默病方面是有用的。本发明还涉及包括这些化合物的制药组合物以及在治疗β-分泌酶酶参与的这些疾病中使用这些化合物和组合物的用途。
• Substituierte Prop-2-in-1-ol- und Prop-2-en-1-ol-Derivate
  申请人：Bayer CropScience AG

  公开号：EP2510786A1

  公开（公告）日：2012-10-17

  Die Erfindung betrifift substituierte Prop-2-in-1-ol- und Prop-2-en-1-ol-Derivate der allgemeinen Formel (I), wobei die Reste R1, R2, R3, R4, R5, [X-Y] und Q die in der Beschreibung angegebenen Definitionen besitzen, Verfahren zu deren Herstellung und ihre Verwendung zur Steigerung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress, sowie zur Stärkung des Pflanzenwachstums und/oder zur Erhöhung des Pflanzenertrags.

  本发明涉及通式（I）的取代丙-2-烯-1-醇和丙-2-烯-1-醇衍生物、 其中自由基 R1、R2、R3、R4、R5、[X-Y] 和 Q 的定义见说明、 它们的制备工艺及其在提高植物对非生物性胁迫的耐受性以及促进植物生长和/或提高植物产量方面的用途。