2'-(((2S,3R,4S,5S)-3,4,5-triacetoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yloxy)carbonylamino)biphenyl-2-carboxylic acid | 320401-51-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2'-(((2S,3R,4S,5S)-3,4,5-triacetoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yloxy)carbonylamino)biphenyl-2-carboxylic acid
• 英文别名: 2-[2-[[(2S,3R,4S,5S,6S)-3,4,5-triacetyloxy-6-methoxycarbonyloxan-2-yl]oxycarbonylamino]phenyl]benzoic acid
• CAS: 320401-51-2
• 化学式: C₂₇H₂₇NO₁₃
• 分子量: 573.51
• InChiKey: YNHRGGBCTYNOMH-ULKMUXEJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  41
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  190
• 氢给体数：
  2
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  2'-(((2S,3R,4S,5S)-3,4,5-triacetoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yloxy)carbonylamino)biphenyl-2-carboxylic acid 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 methyl (2S,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[[(2S,3S,4S,6R)-6-[[(1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]-3-hydroxy-2-methyloxan-4-yl]carbamoyloxy]oxane-2-carboxylate
  参考文献：
  名称：

  A novel β-d-glycosyl carbamate forming reaction

  摘要：

  The synthesis and use of a novel and versatile 1-beta -O-D-glycosyl active carbamate is described. This active carbamate is prepared from an in situ generated isocyanate and is used to prepare 1-beta -O-D-glycosyl carbamates of multi-functionalized primary or secondary amines in high yield and with 100% beta -diastereoselectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01642-7
• 作为产物：
  描述：

  methyl (2S,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[[2-(2-prop-2-enoxycarbonylphenyl)phenyl]carbamoyloxy]oxane-2-carboxylate 在 四(三苯基膦)钯 吗啉 作用下， 以 四氢呋喃 为溶剂， 以93%的产率得到2'-(((2S,3R,4S,5S)-3,4,5-triacetoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yloxy)carbonylamino)biphenyl-2-carboxylic acid
  参考文献：
  名称：

  A novel β-d-glycosyl carbamate forming reaction

  摘要：

  The synthesis and use of a novel and versatile 1-beta -O-D-glycosyl active carbamate is described. This active carbamate is prepared from an in situ generated isocyanate and is used to prepare 1-beta -O-D-glycosyl carbamates of multi-functionalized primary or secondary amines in high yield and with 100% beta -diastereoselectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01642-7

文献信息

• [EN] SELECTIVE KINASE INHIBITORS<br/>[FR] INHIBITEURS SÉLECTIFS DE KINASES
  申请人：PORTOLA PHARM INC

  公开号：WO2013078468A1

  公开（公告）日：2013-05-30

  Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

  提供了用于抑制Syk激酶的嘧啶化合物，用于制备这些化合物的中间体，其制备方法，药物组合物，抑制Syk激酶活性的方法，以及治疗至少部分由Syk激酶活性介导的疾病的方法。