Sodium beta-glycerophosphate | 819-83-0

• 物质功能分类: 生物化工 - 生化试剂
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: Sodium beta-glycerophosphate
• 英文别名: β-sodium glycerophosphate；β-glycerophosphate disodium salt；disodium β-glycerophosphate；Sodium;1,3-dihydroxypropan-2-yl phosphate
• CAS: 819-83-0
• 化学式: C₃H₇O₆P*2Na
• 分子量: 216.038
• InChiKey: BYTBRXJIOINRFR-UHFFFAOYSA-L

物化性质

• 熔点：
  102-104 °C(lit.)
• 稳定性/保质期：
  常温常压下稳定，避免与氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  -5.81
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• RTECS号：
  UA0600000
• 海关编码：
  2919900090
• 安全说明：
  S26,S37/39
• 储存条件：
  请将容器密封保存，并存放在阴凉、干燥处。

SDS

Name:	beta-Glycerophosphoric acid disodium salt pentahydrate 98% (Titr.) Material Safety Data Sheet
Synonym:	Disodium glycerol 2-phosphate; Sodium glycerophosphate
CAS:	819-83-0

Section 1 - Chemical Product MSDS Name:beta-Glycerophosphoric acid disodium salt pentahydrate 98% (Titr.) Material Safety Data Sheet
Synonym:Disodium glycerol 2-phosphate; Sodium glycerophosphate

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
819-83-0	beta-Glycerophosphoric acid disodium s	98	212-464-3

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation. Do not let this chemical enter the environment.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 819-83-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: white
Odor: Not available.
pH: 9.5 (50g/L @ 20C)
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 102-104C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C3H7Na2O6P.5H2O
Molecular Weight: 306.11

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Carbon monoxide, oxides of phosphorus, carbon dioxide.
Hazardous Polymerization: Will not occur.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 819-83-0: UA0600000 LD50/LC50:
Not available.
Carcinogenicity:
beta-Glycerophosphoric acid disodium salt, pentahydrate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 819-83-0: No information available.
Canada
CAS# 819-83-0 is listed on Canada's DSL List.
CAS# 819-83-0 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 819-83-0 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途：用于测定血液中磷酸酶的试剂。

反应信息

• 作为反应物：
  描述：

  Sodium beta-glycerophosphate 在 氢氧化钾 、 ditelluratoargentante(III) 作用下， 生成 rac-Glycerinaldehyd-2-phosphat Natriumsalz
  参考文献：
  名称：

  Gupta, Kalyan Kali Sen; Ghosh, Balaram, Journal of Chemical Research, Miniprint, 1992, # 6, p. 1343 - 1357

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-bis(pivaloyl)glycerol phosphate 在 sodium hydroxide 、 水 作用下， 生成 Sodium beta-glycerophosphate
  参考文献：
  名称：

  [EN] PROCESS FOR THE SYNTHESIS OF BETA GLYCEROL PHOSPHATE
  [FR] PROCÉDÉ DE SYNTHÈSE DE BÊTA GLYCÉROPHOSPHATE

  摘要：

  本发明提供了制备β甘油磷酸及其盐的方法。特别是，本发明提供了高纯度β甘油磷酸的有效合成方法。

  公开号：

  WO2010080969A1

文献信息

• Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling
  作者：Claudia Bonfio、Cécile Caumes、Colm D. Duffy、Bhavesh H. Patel、Claudia Percivalle、Maria Tsanakopoulou、John D. Sutherland

  DOI：10.1021/jacs.8b12331

  日期：2019.3.6

  Starting with a mixture of activated carboxylic acids of different lengths, iterative cycling of acylation and hydrolysis steps allowed for the selection of longer-chain acylglycerol-phosphates. Our results suggest that a selection pathway based on energy-dissipative cycling could have driven the selective synthesis of phospholipids on early Earth.

  生命起源研究的主要目的是寻找从益生元化学到新生生物学的合理转变序列。在这种情况下，了解早期地球上磷脂膜是如何以及何时出现的，对于阐明导致原始细胞出现的益生元途径至关重要。在这里，我们表明将 glycerol-2-phosphate 暴露于酰化剂会导致形成 acylglycerol-phosphates 库。发现中链酰基甘油磷酸酯自组装成囊泡，在各种条件下稳定，并能够保留单核苷酸和寡核苷酸。从不同长度的活化羧酸混合物开始，酰化和水解步骤的迭代循环允许选择更长链的酰基甘油-磷酸酯。
• The pK_a of Brønsted acids controls their reactivity with diazo compounds
  作者：Na Fei、Basilius Sauter、Dennis Gillingham

  DOI：10.1039/c6cc03561b

  日期：——

  We study the O-alkylation of phosphate groups by alkyl diazo compounds in a range of small molecules and biopolymers.

  我们研究了一系列小分子和生物聚合物中烷基重氮化合物对磷酸基团的O-烷基化作用。
• Composite shaped bodies and methods for their production and use
  申请人：Koblish Antony

  公开号：US20050042288A1

  公开（公告）日：2005-02-24

  Shaped, composite bodies are provided. One portion of the shaped bodies comprises an RPR-derived porous inorganic material, preferably a calcium phosphate. Another portion of the composite bodies is a different solid material, preferably metal, glass, ceramic or polymeric. The shaped bodies are especially suitable for orthopaedic and other surgical use.

  提供了成型的复合体。成型体的一部分包括一种RPR衍生的多孔无机材料，最好是磷酸钙。复合体的另一部分是不同的固体材料，最好是金属、玻璃、陶瓷或聚合物。这些成型体特别适用于骨科和其他外科手术。
• 一种制备β-甘油磷酸钠的方法
  申请人：江苏诚信药业有限公司

  公开号：CN105732700B

  公开（公告）日：2018-01-16

  本发明提供一种制备β‑甘油磷酸钠的方法，包括如下步骤：a)酯化、环合：将甘油和无机磷酸盐混合物升温至120～150℃反应120～168小时；b)水解：加入适量的水和30%的氢氧化钠溶液，反应液升温反应8～20小时，取样检测溶液的无机磷含量，根据检测的无机磷含量加入适量的氧化镁，搅拌3～5小时，过滤；c)析晶：滤液降温至20～30℃滴加乙醇，再降温至0～5℃析晶12～28小时，过滤，固体用乙醇洗涤，得到粗品；d)精制：将上面得到的粗品用水溶解，在20～30℃滴加乙醇或甲醇，再降温至0～5℃，析晶12～28小时，过滤，洗涤得到一次精制湿品。
• Dinuclear Copper(II) Complexes with {Cu₂(μ-hydroxo)bis(μ-carboxylato)}⁺ Cores and Their Reactions with Sugar Phosphate Esters:  A Substrate Binding Model of Fructose-1,6-bisphosphatase
  作者：Merii Kato、Tomoaki Tanase、Masahiro Mikuriya

  DOI：10.1021/ic051942d

  日期：2006.4.1

  (4); L = 4,4'-dimethyl-2,2'-bipyridine (Me2bpy), X = NO3 (5); L = 4-methyl-1,10-phenanthroline (Mephen), X = NO3 (6)). Complexes 1-6 were characterized by X-ray crystallography (Cu...Cu = 3.1624(6)-3.2910(4) A), and the electrochemical and magnetic properties were also examined. Complexes 3 and 4 readily reacted with diphenyl phosphoric acid (HDPP) or bis(4-nitrophenyl) phosphoric acid (HBNPP) to give

  CuX2.nH2O与双羧酸盐配体XDK（H2XDK =间二甲苯二胺双（肯普氏三酸酰亚胺））在N供体辅助配体存在下的反应产生了一系列的dicopper（II）配合物，[Cu2（mu-OH）（ XDK）（L）2] X（L = N，N，N'，N'-四甲基乙二胺（tetmen），X = NO3（1a），Cl（1b）; L = N，N，N'-三甲基乙二胺（tmen ），X = NO3（2a），Cl（2b）; L = 2,2'-联吡啶（bpy），X = NO3（3）; L = 1,10-菲咯啉（phen），X = NO3（4） ； L ＝ 4，4′-二甲基-2，2′-联吡啶（Me 2 bpy），X ＝ NO 3（5）； L ＝ 4-甲基-1，10-菲咯啉（Mephen），X ＝ NO 3（6））。配合物1-6用X射线晶体学表征（Cu ... Cu = 3.1624（6）-3.2910（4）A），并且还