2-(2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)-5-hydroxy-8-methyl-1,7-naphthyridine-6-formamido)acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)-5-hydroxy-8-methyl-1,7-naphthyridine-6-formamido)acetic acid
• 英文别名: 2-(2-((2,3-Dihydrobenzo[b][1,4]dioxo-6-yl)oxy)-5-hydroxy-8-methyl-1,7-naphthyridine-6-formamido) acetic acid；2-[[2-(2,3-dihydro-1,4-benzodioxin-6-yloxy)-5-hydroxy-8-methyl-1,7-naphthyridine-6-carbonyl]amino]acetic acid
• 化学式: C₂₀H₁₇N₃O₇
• 分子量: 411.371
• InChiKey: DLGCRYLHUYIBNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  6-羟基-1,4-苯并二噁烷 在 三乙烯二胺 、 N-溴代丁二酰亚胺(NBS) 、 1,2-双(二苯基膦)乙烷氯化镍 、 偶氮二异丁腈 、 sodium methylate 、 potassium carbonate 、 三乙胺 、 sodium iodide 作用下， 以 四氢呋喃 、 甲醇 、 四氯化碳 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 34.0h， 生成 2-(2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)-5-hydroxy-8-methyl-1,7-naphthyridine-6-formamido)acetic acid
  参考文献：
  名称：

  COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF

  摘要：

  公开号：

  EP3275881B1

文献信息

• COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROARYLOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF
  申请人：SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

  公开号：US20180118739A1

  公开（公告）日：2018-05-03

  A compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, a preparation method thereof and a pharmaceutical use thereof are provided. In particular, the compound has the following Formula (I), wherein R 2 and R 3 are each independently H; R 1 is H or C 1 -C 3 alkyl; Ar is an aromatic ring or a heteroaromatic ring selected from a naphthalene ring, a pyridine ring, a thiophene ring, a furan ring and a substituted benzene ring. Pharmaceutically acceptable salts of the present compound, are provided, as well as uses of the compound or pharmaceutically acceptable salts thereof in the preparation of a medicine for inhibiting HIF prolyl hydroxylase or a medicine for promoting the generation of endogenous EPO.
• COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF
  申请人：Shenyang Sunshine Pharmaceutical Co., Ltd.

  公开号：EP3275881B1

  公开（公告）日：2021-08-04