(6-chloro-2-methoxy-acridin-9-yl)-methyl-amine | 4822-23-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (6-chloro-2-methoxy-acridin-9-yl)-methyl-amine
• 英文别名: (6-Chlor-2-methoxy-acridin-9-yl)-methyl-amin；6-Chlor-2-methoxy-9-methylamino-acridin；6-chloro-2-methoxy-N-methylacridin-9-amine
• CAS: 4822-23-5
• 化学式: C₁₅H₁₃ClN₂O
• 分子量: 272.734
• InChiKey: XLSFYNSXABNPTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  34.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (6-chloro-2-methoxy-acridin-9-yl)-methyl-amine 生成 N-(6-chloro-2-methoxy-acridin-9-yl)-N-methyl-acetamide
  参考文献：
  名称：

  Kitani, Nippon Kagaku Zasshi, 1954, vol. 75, p. 475,476

  摘要：

  DOI：
• 作为产物：
  描述：

  6-chloro-2,9-dimethoxyacridine 、 甲胺 在 盐酸 、 甲醇 、 溶剂黄146 作用下， 生成 (6-chloro-2-methoxy-acridin-9-yl)-methyl-amine
  参考文献：
  名称：

  Kitani, Nippon Kagaku Zasshi, 1954, vol. 75, p. 475,476

  摘要：

  DOI：

文献信息

• [EN] ORGANO-TRANSITION METAL COMPLEXES FOR THE TREATMENT OF VIRAL INFECTIONS<br/>[FR] COMPLEXES ORGANOMÉTALLIQUES DE TRANSITION POUR LE TRAITEMENT DES INFECTIONS VIRALES
  申请人：BUSATH DAVID D

  公开号：WO2015192037A1

  公开（公告）日：2015-12-17

  Organo-transition metal complexes possess anti-viral inhibitory activity against influenza A, including the S3 IN mutant. The organo-transition metal complexes include a transition metal and at least one ligand based on the structure of an M2 proton channel blocker. Compounds and pharmaceutical compositions are useful for treating viruses such as influenza A.

  有机过渡金属配合物具有抗流感病毒的抑制活性，包括S3 IN突变体。有机过渡金属配合物包括过渡金属和至少一种基于M2质子通道阻滞剂结构的配体。这些化合物和药物组合物对治疗流感病毒等病毒有用。
• ORGANO-TRANSITION METAL COMPLEXES FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：BUSATH David D.

  公开号：US20170128489A1

  公开（公告）日：2017-05-11

  Organo-transition metal complexes possess anti-viral inhibitory activity against influenza A, including the S3 IN mutant. The organo-transition metal complexes include a transition metal and at least one ligand based on the structure of an M2 proton channel blocker. Compounds and pharmaceutical compositions are useful for treating viruses such as influenza A.
• Dimeric Quinacrine Derivatives As Autophagy Inhibitors For Cancer Therapy
  申请人：The Trustees of the University of Pennsylvania

  公开号：US20210070712A1

  公开（公告）日：2021-03-11

  The invention provides dimeric quinacrine derivatives and related compounds and compositions, methods of treatment and syntheses. The novel compounds exhibit unexpected anticancer activity and are useful in the treatment of a variety of autophagy-related disorders.
• [EN] NUCLEOSIDE AND NUCLEOTIDE CONJUGATE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS CONJUGUÉS DE NUCLÉOSIDE ET DE NUCLÉOTIDE ET LEURS UTILISATIONS
  申请人：REYOUNG CORP

  公开号：WO2021202669A2

  公开（公告）日：2021-10-07

  This disclosure provides nucleoside and nucleotide conjugate compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders, such as viral infections and cancers.
• Kitani, Nippon Kagaku Zasshi, 1954, vol. 75, p. 475,476
  作者：Kitani

  DOI：——

  日期：——