2-(3,4-二乙酰氧基苯基)-3,4-二氢-2H-苯并吡喃-3,5,7-三基三乙酸酯 | 84282-42-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 2-(3,4-二乙酰氧基苯基)-3,4-二氢-2H-苯并吡喃-3,5,7-三基三乙酸酯
• 英文名称: catechin pentaacetate
• 英文别名: 3,5,7-triacetoxy-2-(3,4-diacetoxy-phenyl)-chroman；dl-Catechin-pentaacetat；Penta-O-acetyl-catechin；Pentaacetyl-catechin；2-(3,4-Bis(acetoxy)phenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triyltriacetate；[5,7-diacetyloxy-2-(3,4-diacetyloxyphenyl)-3,4-dihydro-2H-chromen-3-yl] acetate
• CAS: 84282-42-8
• 化学式: C₂₅H₂₄O₁₁
• 分子量: 500.459
• InChiKey: BKYWAYNSDFXIPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  141
• 氢给体数：
  0
• 氢受体数：
  11

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  2-(3,4-二乙酰氧基苯基)-3,4-二氢-2H-苯并吡喃-3,5,7-三基三乙酸酯 在 乙醇 、 potassium acetate 作用下， 生成 acetate of (+)-catechin
  参考文献：
  名称：

  Freudenberg; Boehme; Purrmann, Chemische Berichte, 1922, vol. 55, p. 1746

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(3,4-二羟基苯基)-3,4-二氢-2H-1-苯并吡喃-3,5,7-三醇 、 乙酸酐 生成 2-(3,4-二乙酰氧基苯基)-3,4-二氢-2H-苯并吡喃-3,5,7-三基三乙酸酯
  参考文献：
  名称：

  ELLIGER, C. A., SYNTH. COMMUN., 1985, 15, N 14, 1315-1324

  摘要：

  DOI：

文献信息

• Isolation, purification and synthesis of procyanidin B2 and uses thereof
  申请人：——

  公开号：US20040260076A1

  公开（公告）日：2004-12-23

  Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin B2 in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus Uncaria . The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.

  本发明揭示了合成、分离和纯化原花青素B2的方法。合成方法利用表儿茶素作为起始物质，高产原花青素B2。分离方法从钩藤属植物物质的树皮粉样本中提取原花青素B2。分离和/或合成的原花青素B2用于治疗淀粉样疾病，例如阿尔茨海默病和帕金森病。还揭示了含有合成和/或分离的原花青素B2的制药组合物。
• Compounds for Enhancing Arginase Activity and Methods of USe Thereof
  申请人：Ratan Rajiv R.

  公开号：US20090253782A1

  公开（公告）日：2009-10-08

  The present invention relates to a method for enhancing arginase activity in a damaged or injured cell. In other aspects, the invention provides a method for treating a disorder that can be treated by enhancing arginase activity in a human in need thereof, the method comprising administering to the human an effective amount of a compound that enhances arginase activity. Such disorders include ischemia, hypoxia, neurodegenerative disease or condition, stroke or trauma of the nervous system. In yet another aspect, the invention provides methods for promoting regeneration of a neural cell in a human in need thereof.

  本发明涉及一种增强受损或受伤细胞中精氨酸酶活性的方法。在其他方面，本发明提供了一种治疗可以通过增强人体中精氨酸酶活性来治疗的疾病的方法，该方法包括向患者施用增强精氨酸酶活性的化合物的有效量。这些疾病包括缺血、低氧、神经退行性疾病或情况、中风或神经系统创伤。在另一个方面，本发明提供了促进人体中需要的神经细胞再生的方法。
• Isolation, Purification and Synthesis of Procyanidin B2 and Uses Thereof
  申请人：Snow Alan

  公开号：US20080306286A1

  公开（公告）日：2008-12-11

  Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin B2 in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus Uncaria . The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease as well as improve cognitive performance and increase learning and memory in Alzheimer's patients. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.

  本发明揭示了一种合成、分离和纯化原花青素B2的方法。合成方法利用表儿茶素作为起始材料，并高产地产生原花青素B2。分离方法从野生植物Uncaria属的树皮粉样本中提取原花青素B2。分离和/或合成的原花青素B2用于治疗淀粉样疾病，如阿尔茨海默病和帕金森病，以及改善阿尔茨海默病患者的认知表现和增加学习和记忆能力。还揭示了含有合成和/或分离的原花青素B2的药物组合物。
• Use of procyanidin B2 for the preparation of a medicament for the treatment of amyloid and synuclein diseases
  申请人：Proteotech, Inc.

  公开号：EP1790648A1

  公开（公告）日：2007-05-30

  Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin BZ in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus Uncaria. The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.

  本发明公开了原花青素 B2 的合成、分离和纯化方法。合成方法利用表儿茶素作为起始原料，并以高产率生产原花青素 BZ。分离方法是从钩藤属植物的树皮粉末样品中提取原花青素 B2。分离和/或合成的原花青素 B2 可用于治疗淀粉样变性疾病，如阿尔茨海默氏症和帕金森氏症。还公开了含有合成和/或分离的原花青素 B2 的药物组合物。
• systhesis of procyanidin B2
  申请人：Proteotech Inc.

  公开号：EP1921076A1

  公开（公告）日：2008-05-14

  Methods for the synthesis of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin BZ in high yields.

  本发明公开了原花青素 B2 的合成方法。这些合成方法利用表儿茶素作为起始原料，并以高产率生产原花青素 BZ。