glucose pentaacetate | 1192012-92-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: glucose pentaacetate
• 英文别名: 6-(acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate；alpha-D-Glucopyranose, pentaacetate；(3,4,5,6-tetraacetyloxyoxan-2-yl)methyl acetate
• CAS: 1192012-92-2
• 化学式: C₁₆H₂₂O₁₁
• 分子量: 390.344
• InChiKey: LPTITAGPBXDDGR-UHFFFAOYSA-N

物化性质

• 沸点：
  434.8±45.0 °C(Predicted)
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  141
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  glucose pentaacetate 在 iron(III) chloride 、 copper(l) iodide 、 叠氮基三甲基硅烷 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 溶剂黄146 为溶剂， 反应 2.0h， 生成 1'-(4-(3-thienyl)-[1,2,3]-triazol-1-yl)-2',3',4',6'-tetra-O-acetylglucopyranose
  参考文献：
  名称：

  Ultrasound-assisted one-pot synthesis of anti-CML nucleosides featuring 1,2,3-triazole nucleobase under iron-copper catalysis

  摘要：

  A simple and efficient synthesis of modified 1,2,3-triazole nucleosides was developed. The strategy involved sequential one-pot acetylation-azidation-cycloaddition procedure and was found to be highly effective under a cooperative effect of ultrasound activation and iron/copper catalysis. The reactions were carried out under both conventional and ultrasonic irradiation conditions. In general, improvement in rates and yields were observed when reactions were carried out under sonication compared with conventional conditions. This one-pot procedure provides several advantages such as operational simplicity, high yield, safety and environment friendly protocol. The resulting substituted nucleosides were evaluated for their anticancer activity against K562 chronic myelogenous leukemia (CML) cell line Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ultsonch.2012.04.007
• 作为产物：
  描述：

  glucose 、 乙酸酐 在 iron(III) chloride 作用下， 反应 0.25h， 生成 glucose pentaacetate
  参考文献：
  名称：

  Ultrasound-assisted one-pot synthesis of anti-CML nucleosides featuring 1,2,3-triazole nucleobase under iron-copper catalysis

  摘要：

  A simple and efficient synthesis of modified 1,2,3-triazole nucleosides was developed. The strategy involved sequential one-pot acetylation-azidation-cycloaddition procedure and was found to be highly effective under a cooperative effect of ultrasound activation and iron/copper catalysis. The reactions were carried out under both conventional and ultrasonic irradiation conditions. In general, improvement in rates and yields were observed when reactions were carried out under sonication compared with conventional conditions. This one-pot procedure provides several advantages such as operational simplicity, high yield, safety and environment friendly protocol. The resulting substituted nucleosides were evaluated for their anticancer activity against K562 chronic myelogenous leukemia (CML) cell line Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ultsonch.2012.04.007
• 作为试剂：
  描述：

  1,6-bis-(3-(3-carbomethoxymethylphenyl)-4-hydroxyphenyl)hexane 、 glucose pentaacetate 在 glucose pentaacetate 作用下， 以77的产率得到1,6-Bis-[3-(3-carboxymethylphenyl)-4-(α-D-mannopyranosyloxy)phenyl]-1,6-bis-oxohexane
  参考文献：
  名称：

  J. Med. Chem. 1998, 41, 1099-1111

  摘要：

  DOI：

文献信息

• PREPARATION OF MONOSACCHARIDES, DISACCHARIDES, TRISACCHARIDES, AND PENTASACCHARIDES OF HEPARINOIDS
  申请人：FORMOSA LABORATORIES, INC.

  公开号：US20170015695A1

  公开（公告）日：2017-01-19

  The present invention provides preparations of monosaccharides, disaccharides, trisaccharides, and pentasaccharides of heparinoids. The present invention also provides novel monosaccharides, disaccharides, trisaccharides and pentasaccharides for use in the preparation of heparinoids.

  本发明提供了肝素样单糖、二糖、三糖和五糖的制备方法。本发明还提供了用于制备肝素样化合物的新型单糖、二糖、三糖和五糖。
• [EN] MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS<br/>[FR] DÉRIVÉS DE MANNOSE POUR LE TRAITEMENT D'INFECTIONS BACTÉRIENNES
  申请人：VERTEX PHARMA

  公开号：WO2014100158A1

  公开（公告）日：2014-06-26

  The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula (I). The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.

  本发明涉及用于治疗或预防细菌感染的化合物。这些化合物具有化学式（I）。该发明还提供含有这些化合物的药学上可接受的组合物，以及使用这些组合物治疗细菌感染的方法。最后，该发明提供了制备本发明化合物的方法。
• [EN] CARBOHYDRATE-MEDIATED TUMOR TARGETING<br/>[FR] CIBLAGE DE TUMEURS MÉDIÉ PAR UN HYDRATE DE CARBONE
  申请人：UNIV ARIZONA

  公开号：WO2011019419A1

  公开（公告）日：2011-02-17

  Tumors can be selectively targeted via compounds provided herein according to the formula, or a pharmaceutically acceptable salt thereof, wherein RA and RB are as defined herein. Tumors can be imaged or targeted for therapeutic treatment using compounds described herein where at least one RA or at least one RB group comprises a imaging agent, a therapeutic agent, or a member of a specific binding pair which can be associated with a secondary imaging agent, such as a microbubble for ultrasonic imaging.

  本文提供的化合物可选择性地针对肿瘤，其中根据以下公式或其药用可接受的盐，其中RA和RB如本文所定义。肿瘤可通过本文描述的化合物进行成像或靶向治疗，其中至少一个RA或至少一个RB基团包含成像剂、治疗剂或特定结合对的成员，可与次级成像剂（如用于超声成像的微泡）结合。
• 双杂环三氮唑核苷类似物的抗肿瘤作用与应用
  申请人：辽宁利锋科技开发有限公司

  公开号：CN109503587B

  公开（公告）日：2022-01-11

  本发明的目的是提供一种含有双杂环三氮唑核苷类似物化合物、立体异构体、前药、药用盐、复盐和或溶剂化的化合物具有下列结构通式I,和或其立体异构体，互变异构体，前药，药学可接受的盐，复合盐和或溶剂化合物，具有抗肿瘤作用与应用。
• Modified oligonucleotides and compound that can be used for synthesizing same
  申请人：GUANGZHOU RIBOBIO CO., LTD.

  公开号：US20200369703A1

  公开（公告）日：2020-11-26

  The present disclosure falls within the field of biomedical technology, and in particular relates to modified oligonucleatides and a compound that can be used for synthesizing same and a method for modifying oligonucleotides. The present disclosure also relates to the use of the modified oligonucleotides for preventing and/or treating diseases associated with the liver in a subject.

  本公开涉及生物医学技术领域，特别是涉及改良寡核苷酸和一种可用于合成相同的化合物以及一种修改寡核苷酸的方法。本公开还涉及使用改良寡核苷酸来预防和/或治疗与主体肝脏相关的疾病。