N-hydroxy-7-(8-isopentyl-2-oxo-2H-chromen-7-yloxy)heptanamide | 1335107-68-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: N-hydroxy-7-(8-isopentyl-2-oxo-2H-chromen-7-yloxy)heptanamide
• 英文别名: N-hydroxy-7-[8-(3-methylbutyl)-2-oxochromen-7-yl]oxyheptanamide
• CAS: 1335107-68-0
• 化学式: C₂₁H₂₉NO₅
• 分子量: 375.465
• InChiKey: KEVRYVQWWIUOTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  蛇床子提取物 在 甲醇 、 18-冠醚-6 、 palladium 10% on activated carbon 、 氢气 、 氯甲酸乙酯 、 三溴化硼 、 四丁基碘化铵 、 sodium hydride 、 三乙胺 、 lithium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 、 均三甲苯 为溶剂， 166.0 ℃ 、101.33 kPa 条件下， 反应 43.0h， 生成 N-hydroxy-7-(8-isopentyl-2-oxo-2H-chromen-7-yloxy)heptanamide
  参考文献：
  名称：

  Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors

  摘要：

  Our previous studies have demonstrated that osthole, a Chinese herbal compound, could be incorporated into the hydroxycinnamide scaffold of LBH-589, a potent HDAC inhibitor, as an effective hydrophobic cap; the resulting compounds showed significant potency against several HDAC isoforms. Here, we presented a series of osthole derivatives fused with the aliphatic-hydroxamate core of suberoylanilide hydroxamic acid (SAHA), a clinically-approved HDAC inhibitor. Several compounds showed potent activity against nuclear HDACs. Further assays against individual HDAC isoforms revealed that some compounds showed not only SAHA-like activity towards HDAC1, -4 and -6, they inhibited HDAC8 by log difference than SAHA and thus exhibited a broader HDAC inhibition spectrum. Among them, compound 6g showed potent antiproliferative effect on several human cancer cell lines. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.06.002

文献信息

• Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors
  作者：Wei-Jan Huang、Ching-Chow Chen、Shi-Wei Chao、Chia-Chun Yu、Chen-Yui Yang、Jih-Hwa Guh、Yun-Chieh Lin、Chiao-I. Kuo、Ping Yang、Chung-I. Chang

  DOI：10.1016/j.ejmech.2011.06.002

  日期：2011.9

  Our previous studies have demonstrated that osthole, a Chinese herbal compound, could be incorporated into the hydroxycinnamide scaffold of LBH-589, a potent HDAC inhibitor, as an effective hydrophobic cap; the resulting compounds showed significant potency against several HDAC isoforms. Here, we presented a series of osthole derivatives fused with the aliphatic-hydroxamate core of suberoylanilide hydroxamic acid (SAHA), a clinically-approved HDAC inhibitor. Several compounds showed potent activity against nuclear HDACs. Further assays against individual HDAC isoforms revealed that some compounds showed not only SAHA-like activity towards HDAC1, -4 and -6, they inhibited HDAC8 by log difference than SAHA and thus exhibited a broader HDAC inhibition spectrum. Among them, compound 6g showed potent antiproliferative effect on several human cancer cell lines. (C) 2011 Elsevier Masson SAS. All rights reserved.