O-β-D-galactopyranosyl-(1->4)-O-β-D-glucopyranosyl-(1->4)-D-glucopyranose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O-β-D-galactopyranosyl-(1->4)-O-β-D-glucopyranosyl-(1->4)-D-glucopyranose
• 英文别名: β-D-galactopyranosyl-(1->4)-β-D-glucopyranosyl-(1->4)-D-glucose；O-beta-D-Galactopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-4)-D-glucose；(2S,3R,4S,5R,6R)-2-[(2R,3S,4R,5R,6S)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₁₈H₃₂O₁₆
• 分子量: 504.442
• InChiKey: FYGDTMLNYKFZSV-NDKBOSJPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.9
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  269
• 氢给体数：
  11
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-β-D-glucopyranosyl-amine 在 D-galactosyltransferase 、 Poly(acrylamide)-poly(N-acryloxysuccinimide) 、 氢气 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N'-二环己基碳二亚胺 、 α-chymotrypsin 、 α-lactalbumin 作用下， 以 二氯甲烷 为溶剂， 生成 O-β-D-galactopyranosyl-(1->4)-O-β-D-glucopyranosyl-(1->4)-D-glucopyranose
  参考文献：
  名称：

  Enzymic synthesis of oligosaccharides on an α-chymotrypsin-sensitive polymer. O-(β-d-Galactopyranosyl)-(1→4)-O-(β-d-glucopyranosyl)-(1→4)-d-glucopyranose

  摘要：

  DOI：

  10.1016/0008-6215(84)85212-x

文献信息

• Synthesis of Galactose-Terminated Oligosaccharides by Use of Galactosyltransferase
  作者：Joachim Thiem、Torsten Wiemann

  DOI：10.1055/s-1992-34174

  日期：——

  Galactosyltransferase catalyzes the galactosylation of oligosaccharides terminated by glucose and by 2-acetamido-2-deoxy glucopyranose, respectively. Variations concerning the acceptor substrate as well as the donor substrate are described.

  半乳糖基转移酶分别催化以葡萄糖和2-乙酰胺基-2-脱氧吡喃葡萄糖为末端的多糖的半乳糖基化反应。本文描述了关于受体底物和供体底物的变化。
• Enzymatic Galactosylation of Cello‐ and Chito‐Oligomers
  作者：Harald Streicher、Oliver Scheel、Joachim Thiem

  DOI：10.1080/07328300802030779

  日期：2008.5

  Terminal galactosylations of cello- and chito-oligomers are studied employing galactosyltransferase with and without alpha-lactalbumin. The lactose synthase complex allows just for galactosylation of cellobiose in lower yield but not for higher cello-oligomers. In contrast, the affinity in galactosylation of chito-oligomers increases with higher members to reach the maximum at chitohexaose with only a 30% reduction in transfer rate. In addition to kinetic data, preparative studies with a number of acceptor substrates gave galactosylated oligosaccharides in high yields.[GRAPHICS]