α-bromo-isobutyraldehyde dimethylacetal | 36365-21-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-bromo-isobutyraldehyde dimethylacetal
• 英文别名: α-Brom-isobutyraldehyd-dimethylacetal；2-bromo-2,2-dimethylbutyraldehyde dimethylacetal；1,1-dimethoxy 2-bromo-2-methylpropane；2-Bromo-1,1-dimethoxy-2-methylpropane
• CAS: 36365-21-6
• 化学式: C₆H₁₃BrO₂
• 分子量: 197.072
• InChiKey: ZUAFAIVEEWFGAR-UHFFFAOYSA-N

物化性质

• 沸点：
  59 °C(Press: 16 Torr)
• 密度：
  1.280±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  α-bromo-isobutyraldehyde dimethylacetal 在 盐酸 作用下， 生成 2-溴-2-甲基丙醛
  参考文献：
  名称：

  Bedoukian, Journal of the American Chemical Society, 1944, vol. 66, p. 1326

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 四氯化碳 、 溴 作用下， 生成 α-bromo-isobutyraldehyde dimethylacetal
  参考文献：
  名称：

  Bedoukian, Journal of the American Chemical Society, 1944, vol. 66, p. 1326

  摘要：

  DOI：

文献信息

• The Mukaiyama reaction of ketene bis(trimethylsilyl) acetals with α-halo acetals
  作者：F.W.J. Demnitz

  DOI：10.1016/s0040-4039(01)93317-9

  日期：——

  Ketene bis(trimethylsilyl) acetals were reacted with α-halo acetals giving β-alkoxy-γ-halo acids which were converted to butenolides by reaction with two equivalents of base. This constitutes a novel and short butenolide synthesis.

  使乙烯酮双（三甲基甲硅烷基）乙缩醛与α-卤代乙缩醛反应，得到β-烷氧基-γ-卤代酸，通过与两当量的碱反应将其转化为丁烯化物。这构成了新颖且短的丁烯内酯合成。
• [EN] 2'-O-AMINOOXYMETHYL NUCLEOSIDE DERIVATIVES FOR USE IN THE SYNTHESIS AND MODIFICATION OF NUCLEOSIDES, NUCLEOTIDES AND OLIGONUCLEOTIDES<br/>[FR] DÉRIVÉS DE 2'-O-AMINOOXYMÉTHYL NUCLÉOSIDE POUR L'UTILISATION DANS LA SYNTHÈSE ET LA MODIFICATION DE NUCLÉOSIDES, NUCLÉOTIDES ET OLIGONUCLÉOTIDES
  申请人：US HEALTH

  公开号：WO2012138530A1

  公开（公告）日：2012-10-11

  Disclosed are O-protected compounds of the formula (I):wherein B is an optionally protected nucleobase, and R1-R3 are as described herein, a method of preparing such compounds, and a method of preparing oligonucleotides such as RNA starting from such compounds. The O-protected compounds have one or more advantages, for example, the 2'-O-protected compound is stable during the various reaction steps involved in oligonucleotide synthesis; the protecting group can be easily removed after the synthesis of the oligonucleotide, for example, by reaction with tetrabutylammonium fluoride; and/or the O-protected groups do not generate DNA/RNA alkylating side products, which have been reported during removal of 2'-O-(2-cyanoethyl)oxymethyl or 2'-O-[2-(4-tolylsulfonyl)ethoxymethyl groups under similar conditions.

  揭示了公式（I）中的O-保护化合物：其中B是可选择保护的核碱基，R1-R3如本文所述，一种制备这种化合物的方法，以及一种从这种化合物开始制备寡核苷酸（如RNA）的方法。这些O-保护化合物具有一个或多个优点，例如，2'-O-保护化合物在寡核苷酸合成中涉及的各种反应步骤中是稳定的；保护基在寡核苷酸合成后可以轻松去除，例如，通过与四丁基氟化铵反应；和/或O-保护基在类似条件下去除2'-O-(2-氰乙基)氧甲基或2'-O-[2-(4-甲苯磺酰基)乙氧甲基基团时不会产生已报道的DNA/RNA烷基化副产物。
• Ketene Chemistry 2.¹A General Procedure for the Synthesis of 2-Alkoxycyclopropane-carboxylic Esters and Acids Starting from Aldehydes and Ketene
  作者：Preben Bødstrup Rasmussen、Søren Bøwadt

  DOI：10.1055/s-1989-27165

  日期：——

  Alkyl 3-alkoxy-4-bromocarboxylates are prepared by the Lewis acid-catalyzed reaction of α-bromoaldehyde acetals with ketene. Base-catalyzed cyclization of these intermediates affords 2-alkoxycyclopropanecarboxylic esters.

  通过Lewis酸催化下的反应，将α-溴醛缩二醇与烯酮反应，制备出烷基3-烷氧基-4-溴羧酸酯。这些中间体在碱催化下发生环化反应，生成2-烷氧基环丙烷羧酸酯。
• 12-Hetero-substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizium salts and compositions and method of use thereof
  申请人：STERLING WINTHROP INC.

  公开号：EP0648769A1

  公开（公告）日：1995-04-19

  12-Hetero substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.

  12-杂取代的 6,11-乙hano-6,11-dihydrobenzo[b]quinolizinium 盐、含有它们的药物组合物，以及利用它们治疗或预防神经退行性疾病或神经毒性损伤的方法。
• Bellesia, Franco; Boni, Monica; Ghelfi, Franco, Gazzetta Chimica Italiana, 1993, vol. 123, # 11, p. 629 - 632
  作者：Bellesia, Franco、Boni, Monica、Ghelfi, Franco、Pagnoni, Ugo Maria

  DOI：——

  日期：——