MILD AND CONVENIENT ONE POT SYNTHESIS OFN-HYDROXYIMIDES FROMN-UNSUBSTITUTED IMIDES
摘要:
A new, one pot synthesis of various N-hydroxyimides from N-unsubstituted imides is described. Imides are first transformed into their N-Boc derivatives, which are next reacted with aqueous hydroxylamine, providing crystalline hydroxylammonium salts of the corresponding N-hydroxyimides. Filtration and acidic workup affords pure N-hydroxyimides.
Alkyl−(Hetero)Aryl Bond Formation via Decarboxylative Cross-Coupling: A Systematic Analysis
作者:Frederik Sandfort、Matthew J. O'Neill、Josep Cornella、Laurin Wimmer、Phil S. Baran
DOI:10.1002/anie.201612314
日期:2017.3.13
useful surrogates for alkylhalides in cross‐coupling chemistry. Such esters are easily accessible through reactions between ubiquitous carboxylic acids and coupling agents widely used in amide bond formation. This article features an amalgamation of in‐house experience bolstered by approximately 200 systematically designed experiments to accelerate the selection of ideal reaction conditions and activating
Modular Synthesis of Drimane Meroterpenoids Leveraging Decarboxylative Borylation and Suzuki Coupling
作者:Xia Wang、Shasha Zhang、Pengcheng Cui、Shengkun Li
DOI:10.1021/acs.orglett.0c03294
日期:2020.11.6
conspicuous challenge. A new paradigm merging decarboxylative borylation and Suzukicoupling was developed as a powerful platform. Key features include the mild conditions, good chemoselectivity, operational facility, scalability, and easy availability of the coupling partners. This practical strategy enables the expedient formal synthesis of a large number of natural products and rapid generation of analogues
PROCESS FOR THE PREPARATION OF NITRO COMPOUNDS AND METHOD FOR THE REMOVAL OF NITROGEN DIOXIDE
申请人:Daicel Chemical Industries, Ltd.
公开号:EP1099684A1
公开(公告)日:2001-05-16
In the invented process for producing a nitro compound, an organic substrate and nitrogen dioxide are reacted in the presence of oxygen or are reacted in a molar ratio of nitrogen dioxide to the organic substrate of less than 1 to yield a corresponding nitro compound. The reaction may be performed in the presence of N-hydroxyphthalimide or other imide compounds. Such organic substrates include (a) aliphatic hydrocarbons, (b) alicyclic hydrocarbons, (c) non-aromatic heterocyclic compounds each having a carbon atom on a ring, which carbon atom is bonded to a hydrogen atom, (d) compounds each having a carbon-hydrogen bond at the adjacent position to an aromatic ring, and (e) compounds each having a carbon-hydrogen bond at the adjacent position to a carbonyl group. This process can efficiently nitrate an organic substrate even under relatively mild conditions.
Ligand‐Controlled Regiodivergence in Nickel‐Catalyzed Hydroarylation and Hydroalkenylation of Alkenyl Carboxylic Acids**
作者:Zi‐Qi Li、Yue Fu、Ruohan Deng、Van T. Tran、Yang Gao、Peng Liu、Keary M. Engle
DOI:10.1002/anie.202010840
日期:2020.12.14
the ligand environment around the metal center dictates the regiochemical outcome. Markovnikov hydrofunctionalization products are obtained under mild ligand‐free conditions, with up to 99 % yield and >20:1 selectivity. Alternatively, anti‐Markovnikov products can be accessed with a novel 4,4‐disubstituted Pyrox ligand in excellent yield and >20:1 selectivity. Both electronic and stericeffects on the