methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,3-²H-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-non-2-ulopyranoside]onate | 1606160-03-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,3-²H-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-non-2-ulopyranoside]onate
• CAS: 1606160-03-5
• 化学式: C₂₆H₃₃NO₁₂S
• 分子量: 585.598
• InChiKey: NPLKOUSSDBQHEN-IJYNXQECSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  40.0
• 可旋转键数：
  11.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  169.83
• 氢给体数：
  1.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,3-²H-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-non-2-ulopyranoside]onate 在 N-碘代丁二酰亚胺 、 三氟甲磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 17.0h， 以96%的产率得到methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-2,6-anhydro-3,5-dideoxy-3-²H-D-glycero-D-galacto-non-2-enonate
  参考文献：
  名称：

  Synthesis and Elimination of C-3-Labeled Thiosialosides

  摘要：

  The synthesis of C-3-labeled phenylthio sialic acid derivatives and an investigation of stereoselectivity in elimination reactions for the synthesis of 2,3-dehydro derivatives (glycals) is described. The experimental results are consistent with the existence of a conformational change and may be indicative of the intermediacy of an all-axial oxacarbenium ion.

  DOI：

  10.1021/ol500917k
• 作为产物：
  描述：

  N-acetyl neuraminic acid 在 sodium hydroxide 、 N,N-二异丙基乙胺 、 乙酰氯 作用下， 以 吡啶 、 甲醇 、 二氯甲烷 、 重水 为溶剂， 反应 66.0h， 生成 methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,3-²H-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-non-2-ulopyranoside]onate
  参考文献：
  名称：

  Synthesis and Elimination of C-3-Labeled Thiosialosides

  摘要：

  The synthesis of C-3-labeled phenylthio sialic acid derivatives and an investigation of stereoselectivity in elimination reactions for the synthesis of 2,3-dehydro derivatives (glycals) is described. The experimental results are consistent with the existence of a conformational change and may be indicative of the intermediacy of an all-axial oxacarbenium ion.

  DOI：

  10.1021/ol500917k