毒理性
对氯丙烯职业暴露影响的流行病学调查进行了研究。研究组由53名工人组成（39名女性），年龄在18至51岁之间，在中国人民共和国的两家制造氯丙烯磺酸钠的工厂工作。对受试者进行了详细的职业和医疗历史问卷调查。进行了身体和神经学检查。进行了电神经肌电图测量。测量了环境中氯丙烯的空气浓度。两家工厂中氯丙烯的浓度分别为2.6至6,650和0.2至25.13毫克/立方米。氯丙烯浓度较低的工厂较新。在旧工厂和新工厂的受试者暴露时间分别为2.5个月至6年和1至4.5年。旧工厂中超过92%的受试者报告四肢无力。其他报告的症状包括四肢感觉异常和麻木。电神经肌电图显示神经病流行率为52.6%。在新工厂中，大约67%的受试者报告四肢无力。其他报告的症状包括手和脚麻木以及头晕。新工厂有异常神经学体征的受试者数量较少。48%的工人的电神经肌电图检查结果显示轻度神经病。未发现其他器官有显著异常。得出结论，工业暴露于氯丙烯的主要风险是对周围神经系统的损害。多发性神经病被认为是慢性氯丙烯暴露的主要临床表现。
An epidemiological survey of the effects of occupational exposure to allyl chloride was conducted. The study group consisted of 53 workers, (39 female) aged 18 to 51, working in two factories in the Peoples Republic of China that manufactured sodium allyl sulfonate. The subjects were given detailed questionnaires about their occupational and medical histories. Physical and neurological examinations were administered. Electroneuromyographic measurements were made. Ambient air concentrations of allyl chloride were measured. Allyl chloride concentrations ranged from 2.6 to 6,650 and 0.2 to 25.13 mg/cu m in the two factories. The factory with the lower allyl chloride concentrations was newer. The durations of exposure of the subjects in the older and newer factories were 2.5 months to 6 years and 1 to 4.5 years, respectively. More tan 92% of the subjects in the older factory reported weakness in the extremities. Other symptoms reported included paraesthesia and numbness in the extremities. Electroneuromyograph showed a neuropathy prevalence of 52.6%. In the newer factory, approximately 67% of the subjects reported weakness in the extremities. Other reported symptoms included numbness of hands and feet and dizziness. the number of subjects with abnormal neurological signs was smaller in the newer factory. Forty eight percent of the workers had electroneuromyograch findings indicating mild neuropathy. No significant abnormalities of other organs were noted. It was concluded that the main risk of industrial exposure to allyl chloride is damage to the peripheral nervous system. Polyneuropathy is thought to be the main clinical manifestation of chronic allyl chloride exposure.
来源:Hazardous Substances Data Bank (HSDB)
