9-(2,6-dibromophenoxycarbonyl)-2,7-dimethoxy-10-(3-succinimidyloxycarbonylpropyl)acridinium Iodide | 1332927-29-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-(2,6-dibromophenoxycarbonyl)-2,7-dimethoxy-10-(3-succinimidyloxycarbonylpropyl)acridinium Iodide
• 英文别名: 2,7-dimethoxy-9-(2,6-dibromophenoxycarbonyl)-10-(3-succinimidyloxycarbonylpropyl)acridinium iodide；2,7-Dimethoxy-9-(2,6-dibromophenoxycarbonyl)-10-(3-succinimidyloxycarbonylpropyl)acridinium iodide；(2,6-dibromophenyl) 10-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutyl]-2,7-dimethoxyacridin-10-ium-9-carboxylate;iodide
• CAS: 1332927-29-3
• 化学式: C₃₀H₂₅Br₂N₂O₈*I
• 分子量: 828.25
• InChiKey: WPYXZMBCBWDOKL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.43
• 重原子数：
  43
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  112
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  4,4'-二甲氧基二苯胺 在 AlCl₃ 盐酸 、 氯化亚砜 、 KOH 作用下， 以 吡啶 、 二氯甲烷 、 水 、 乙腈 为溶剂， 生成 9-(2,6-dibromophenoxycarbonyl)-2,7-dimethoxy-10-(3-succinimidyloxycarbonylpropyl)acridinium Iodide
  参考文献：
  名称：

  CHEMILUMINESCENT PROBES FOR MULTIPLEX MOLECULAR QUANTIFICATION AND USES THEREOF

  摘要：

  本文揭示了一种新的方法，用于同时检测和定量两个或更多核酸靶标，无需扩增。该方法依赖于独立杂交诱导化学发光信号（HICS）探针发出的化学发光的光谱-时间分辨率。通过在灵敏和同时独立定量多个细菌和真菌靶序列的均相分析中使用可分辨的N-连接丙二酰胺和2,7-二甲氧基丙二酰胺酯标记的探针，证明了该方法的实用性。还公开了用于实施本发明方法的组合物和试剂盒。

  公开号：

  US20120231459A1

文献信息

• Simultaneous Quantification of Multiple Nucleic Acid Targets Using Chemiluminescent Probes
  作者：Kenneth A. Browne、Dimitri D. Deheyn、Gamal A. El-Hiti、Keith Smith、Ian Weeks

  DOI：10.1021/ja202221h

  日期：2011.9.21

  A novel method is described for simultaneous detection and quantification of attomoles or a few femtomoles of two (or potentially more) nucleic acid targets, without need for amplification. The technique depends on spectral-temporal resolution of chemiluminescence emitted from independent hybridization-induced chemiluminescent signal probes. The probes are internally quenched except in the presence of their specific targets, thereby allowing detection limits up to 10 000 times lower than with fluorescent probes. This is sufficient to obviate the need for amplification in many cases. The utility of the technique has been demonstrated by use of resolvable N-linked acridinium and 2,7-dimethoxy-acridinium ester labeled probes in a homogeneous assay for sensitive and simultaneous independent quantification of pan-bacterial and pan-fungal target sequences in seawater.
• CHEMILUMINESCENT PROBES FOR MULTIPLEX MOLECULAR QUANTIFICATION AND USES THEREOF
  申请人：BROWNE Kenneth A.

  公开号：US20120231459A1

  公开（公告）日：2012-09-13

  A novel method is disclosed for simultaneous detection and quantification of two or more nucleic acid targets, without need for amplification. The method depends on spectral-temporal resolution of chemiluminescence emitted from independent hybridization-induced chemiluminescent signal (HICS) probes. The utility of this method has been demonstrated by use of resolvable N-linked acridinium and 2,7-dimethoxyacridinium ester labeled probes in a homogeneous assay for sensitive and simultaneous independent quantification of several bacterial and fungal target sequences. Compositions and kits for practicing the method of the present invention are also disclosed.

  本文揭示了一种新的方法，用于同时检测和定量两个或更多核酸靶标，无需扩增。该方法依赖于独立杂交诱导化学发光信号（HICS）探针发出的化学发光的光谱-时间分辨率。通过在灵敏和同时独立定量多个细菌和真菌靶序列的均相分析中使用可分辨的N-连接丙二酰胺和2,7-二甲氧基丙二酰胺酯标记的探针，证明了该方法的实用性。还公开了用于实施本发明方法的组合物和试剂盒。