(2E,4E)-2,4-dimethylhexa-2,4-dienoic acid | 241806-94-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2E,4E)-2,4-dimethylhexa-2,4-dienoic acid
• 英文别名: 2,4-dimethylhexa-2,4-dienoic acid
• CAS: 241806-94-0
• 化学式: C₈H₁₂O₂
• 分子量: 140.182
• InChiKey: RJMYWDGRGHUHAH-YDFGWWAZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2E,4E)-2,4-dimethylhexa-2,4-dienoic acid 在 titanium(IV) isopropylate 、 盐酸 、 六甲基磷酰三胺 、 sodium hexamethyldisilazane 、 caesium carbonate 、 三乙胺 、 lithium chloride 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 生成 乳霉素
  参考文献：
  名称：

  Efficient synthesis of enantiomeric pairs of thiolactomycin and its 3-demethyl derivative

  摘要：

  Starting with commercially available tiglic aldehyde, the title synthesis was achieved by employing deconjugative asymmetric alpha-sulfenylation of the chiral 3-(alpha,beta,gamma,delta-unsaturated acyl)-2-oxazolidinone with a methanethiosulfonate as a key step. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.02.058
• 作为产物：
  描述：

  ethyl (2E,4E)-2,4-dimethylhexa-2,4-dienoate 在 sodium hydroxide 、 水 、 盐酸 作用下， 以 乙醇 为溶剂， 反应 16.0h， 以10.1 g的产率得到(2E,4E)-2,4-dimethylhexa-2,4-dienoic acid
  参考文献：
  名称：

  硫菌霉素及其3-脱甲基衍生物对映体对的高效合成和生物活性

  摘要：

  通过使用手性3-（α，β，γ，δ-不饱和酰基）恶唑烷-2-酮与3,3-二甲氧基丙基甲硫代磺酸盐的键合不对称α-亚磺酰基化作为关键步骤来实现标题的总合成。从使用标题化合物进行的生物学活性测定中，似乎表明，不仅通过改变C 3位的取代基，而且通过改变C的绝对构型，可以清楚地分离体外的抗菌和哺乳动物I型FAS抑制活性。5位，并且非天然的（S）-（-）-3-脱甲基硫基催乳素及其同源物可以用作选择性的哺乳动物I型FAS抑制剂。

  DOI：

  10.1016/j.tet.2009.01.054

文献信息

• Correlation of Hydrolysis and Desilylation of 2-[(Trimethylsilyl)methyl]acrylate Derivatives in Aqueous Alkali Solutions
  作者：Chiaki Kuroda、Takeshi Sunakawa、Yuichi Muguruma

  DOI：10.1002/hlca.200890093

  日期：2008.5

  Hydrolysis and desilylation reaction of 2-[(trimethylsilyl)methyl]acrylate (=2-[(trimethylsilyl)methyl]prop-2-enoate) derivatives were studied to evaluate the effect of the presence/absence of a further conjugating substituent (Schemes 3 and 4 and Tables 1 and 2). The substrates having a nonconjugating substituent at the acrylate moiety were stable to dilute alkali conditions, and afforded simple hydrolysis

  研究了2-[（（三甲基甲硅烷基）甲基]丙烯酸（= 2-[（（三甲硅烷基）甲基]丙-2-烯酸酯）衍生物的水解和脱甲硅基反应，以评估是否存在其他偶联取代基的效果（方案3和4以及表1和2）。在丙烯酸​​酯部分具有非共轭取代基的底物在稀碱条件下是稳定的，并在浓碱条件下提供简单的水解产物。相反，水解和去甲硅烷基化反应都发生在丙烯酸酯骨架上带有共轭取代基的底物上。反应性的差异可以用中间阴离子的稳定性来解释。
• The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase
  作者：Marie E. Yurkovich、Robert Jenkins、Yuhui Sun、Manuela Tosin、Peter F. Leadlay

  DOI：10.1039/c6cc09934c

  日期：——

  Thiotetronate polyketide assembly by an unusual iterative synthase is reconstructed via in vitro enzymology and chemical probes.

  通过体外酶学和化学探针重建不寻常的迭代合酶形成的硫杂环丁酸酯聚酮化合物。
• PROCESSES FOR PRODUCING THERMOPLASTIC RESINS, CROSSLINKED RESINS AND CROSSLINKED RESIN COMPOSITE MATERIALS
  申请人：ZEON CORPORATION

  公开号：EP1535941A1

  公开（公告）日：2005-06-01

  The invention relates to a process for the production of post-crosslinkable thermoplastic resins by bulk-polymerizing a polymerizable composition (A) comprising (I) a monomer fluid containing a cyclic olefin (α) having two or more metathetical ring-opening reaction sites in the molecule in an amount 10 wt% or above based on the total amount of the monomers or a monomer fluid containing a norbornene monomer and a crosslinking agent, (II) a metathetical polymerization catalyst, and (III) a chain transfer agent; thermoplastic resins obtained by this process; and a process for producing crosslinked resins or crosslinked resin composite materials which comprises laminating such a thermoplastic resin with a substrate at need and then crosslinking the thermoplastic resin. According to the invention, thermoplastic resins which are free from odor due to residual monomers and excellent in storage stability can be efficiently obtained by a simple process of bulk-polymerizing the composition (A). The process is not only easy and simple but also applicable to continuous production, thus being industrially advantageous. The crosslinked resins and crosslinked resin composite materials obtained according to the invention are excellent in electrical insulation properties, mechanical strengths, heat resistance, dielectric characteristics and so on, thus being useful as electrical materials or the like.

  本发明涉及一种通过批量聚合可聚合组合物（A）来生产可后交联热塑性树脂的工艺，该组合物（A）包含（I）单体流体，该单体流体含有分子中具有两个或两个以上元开环反应位点的环烯烃（α），其含量为单体总量的 10 wt%或以上，或含有降冰片烯单体和交联剂的单体流体、(II) 元聚合催化剂，以及 (III) 链转移剂；通过该工艺获得的热塑性树脂；以及生产交联树脂或交联树脂复合材料的工艺，该工艺包括在需要时将这种热塑性树脂与基材层压，然后使热塑性树脂交联。根据本发明，通过组合物（A）的简单批量聚合工艺，可以有效地获得无残留单体气味且储存稳定性极佳的热塑性树脂。该工艺不仅简单易行，而且适用于连续生产，因此具有工业优势。根据本发明获得的交联树脂和交联树脂复合材料具有优异的电绝缘性能、机械强度、耐热性、介电特性等，因此可用作电气材料或类似材料。
• POLYMERIZABLE COMPOSITION, THERMOPLASTIC RESIN COMPOSITION, CROSSLINKED RESIN, AND CROSSLINKED RESIN COMPOSITE MATERIALS
  申请人：ZEON CORPORATION

  公开号：EP1589054A1

  公开（公告）日：2005-10-26

  A polymerizable composition which comprises (i) a cycloolefin monomer, (ii) a metathesis polymerization catalyst, (iii) a chain transfer agent, (iv) a radical crosslinking agent, and (v) a compound (α) selected from the group consisting of compounds having alkoxyphenol structures wherein each aromatic ring has one or more substituents, compounds having aryloxyphenol structures, and compounds having catechol structures wherein each aromatic ring has two or more substituents; a thermoplastic resin composition which comprises (1) a cycloolefin thermoplastic resin, (2) a radical crosslinking agent, and (3) a compound (α) ; a process for the production thereof; a crosslinked resin obtained by crosslinking the thermoplastic resin composition; and crosslinked resin composite materials produced by laminating a substrate with the thermoplastic resin composition and crosslinking the thermoplastic resin composition. The invention provides a polymerizable composition useful as raw material in the production of a thermoplastic resin composition excellent in storage stability and fluidity in heat lamination; a thermoplastic resin composition and a process for the production thereof; a crosslinked resin obtained by crosslinking the thermoplastic resin composition; and crosslinked resin composite materials exhibiting excellent interlayer adhesion.

  一种可聚合组合物，它包括(i)环烯烃单体，(ii)偏聚催化剂，(iii)链转移剂，(iv)自由基交联剂，和(v)选自以下组别的化合物(α)：具有烷氧基苯酚结构的化合物，其中每个芳香环有一个或多个取代基；具有芳氧基苯酚结构的化合物；以及具有邻苯二酚结构的化合物，其中每个芳香环有两个或多个取代基；一种热塑性树脂组合物，它包括：(1) 环烯烃热塑性树脂；(2) 自由基交联剂；(3) 化合物 (α)；其生产工艺；通过交联该热塑性树脂组合物而获得的交联树脂；以及通过将基材与该热塑性树脂组合物层压并交联该热塑性树脂组合物而生产的交联树脂复合材料。本发明提供了一种可聚合组合物，可作为生产热塑性树脂组合物的原料，该组合物具有优异的储存稳定性和热层压流动性；一种热塑性树脂组合物及其生产工艺；一种通过交联该热塑性树脂组合物而获得的交联树脂；以及具有优异层间粘合性的交联树脂复合材料。
• PROCESS FOR PRODUCING CYCLOOLEFIN RESIN FILM AND PROCESS FOR PRODUCING CYCLOOLEFIN POLYMER SHEET OR FILM
  申请人：ZEON CORPORATION

  公开号：EP1589055A1

  公开（公告）日：2005-10-26

  A process (1) for producing a cycloolefin resin film comprising the steps of: the step (I) of mixing a cycloolefin monomer and a metathesis polymerization catalyst to prepare a polymerizable composition (A); the step (II) of coating or impregnating the supporting body with the polymerizable composition (A) at once after the step(I), and the step (III) of polymerizing the polymerizable composition (A) by bulk polymerization; and a process (2) for producing a cycloolefin polymer sheet or film with the thickness of 1 mm or less comprising polymerizing a reactive solution containing a ruthenium complex catalyst, having a hetero atom-containing carbene compound as a ligand, and a cycloolefin monomer by ring-opening metathesis bulk polymerization, wherein the polymerization of the cycloolefin monomer is completed by heating the reactive solution to 100°C or higher at the heating rate of 20°C/min or more. Thus, a cycloolefin resin film having excellent adhesion to other materials and a cycloolefin polymer sheet of film having a thickness of 1 mm or smaller can be efficiently produced.

  一种生产环烯烃树脂薄膜的工艺（1），包括以下步骤：步骤(I)混合环烯烃单体和偏聚催化剂，制备可聚合组合物(A)； 步骤(II)在步骤(I)后立即用可聚合组合物(A)涂覆或浸渍支撑体，以及 步骤(III)通过批量聚合使可聚合组合物(A)聚合；以及一种生产厚度为 1 毫米或以下的环烯烃聚合物片材或薄膜的工艺 (2)，该工艺包括通过开环偏合成批量聚合将含有钌络合物催化剂的反应溶液和环烯烃单体聚合，钌络合物催化剂具有含杂原子的碳烯化合物作为配体，其中环烯烃单体的聚合是通过以 20°C/min 或更高的加热速率将反应溶液加热至 100°C 或更高来完成的。因此，可以有效地生产出与其他材料具有良好粘附性的环烯烃树脂薄膜和厚度为 1 毫米或更小的环烯烃聚合物薄膜片材。