Sulfonamides incorporating fluorine and 1,3,5-triazine moieties are effective inhibitors of three<b>β</b>-class carbonic anhydrases from<i>Mycobacterium tuberculosis</i>
作者:Mariangela Ceruso、Daniela Vullo、Andrea Scozzafava、Claudiu T. Supuran
DOI:10.3109/14756366.2013.842233
日期:2014.10.1
A new series of fluorine containing 1,3,5-triazinyl sulfonamide derivatives obtained from cyanuric fluoride, sulfanilamide/4-aminoethylbenzenesulfonamide followed and incorporating also amin0, amino alcohol and amino acid moieties have been investigated as inhibitors of three β-carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogen Mycobacterium tuberculosis, mtCA1 (Rv1284), mtCA 2 (Rv3588c)
研究了一系列新的含有1,3,5-三嗪基磺酰胺衍生物的氟,该衍生物得自氰尿酰氟,磺胺/ 4-氨基乙基苯磺酰胺,随后还掺入了氨基,氨基醇和氨基酸部分作为三种β-碳酸酐酶(CAs)的抑制剂,例如,来自细菌病原体结核分枝杆菌mtCA1(Rv1284),mtCA 2(Rv3588c)和mtCA 3(Rv3273)的EC 4.2.1.1)。所有三种酶均被这些磺酰胺有效抑制,KI值在纳摩尔或亚微摩尔范围内,这取决于在1,3,5-三嗪环上一个或两个氟原子的取代。由于这些酶中的某些对细菌的生命周期至关重要,