erythromycin-9-[O-(2,3-epoxypropyl)]oxime | 93488-70-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: erythromycin-9-[O-(2,3-epoxypropyl)]oxime
• CAS: 93488-70-1
• 化学式: C₄₀H₇₂N₂O₁₄
• 分子量: 805.017
• InChiKey: VDLZUTHVPMOXLR-HMEKHNNZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.99
• 重原子数：
  56.0
• 可旋转键数：
  10.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  210.96
• 氢给体数：
  5.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  erythromycin-9-[O-(2,3-epoxypropyl)]oxime 、 2-苯乙胺 以 氯仿 为溶剂， 反应 73.0h， 生成 erythromycin-9-[O-(3-(2-phenylethylamino)-2-hydroxy)propyl]oxime
  参考文献：
  名称：

  Synthesis and antimicrobial activity of erythromycin-A oxime analogs

  摘要：

  A series of erythromycin-A oxime ether as well as esters have been synthesized. Ether derivatives were synthesized through the epoxy ether intermediate of erythromycin-9-oxime, followed by opening of the epoxy linkage through various amines, whereas esters have been prepared through DCC mediated protocol. These derivatives have been evaluated for antibacterial activity and found to be as active as erythromycin-A. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.05.011
• 作为产物：
  描述：

  红霉素 在 吡啶 、 盐酸羟胺 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 79.0h， 生成 erythromycin-9-[O-(2,3-epoxypropyl)]oxime
  参考文献：
  名称：

  Synthesis and antimicrobial activity of erythromycin-A oxime analogs

  摘要：

  A series of erythromycin-A oxime ether as well as esters have been synthesized. Ether derivatives were synthesized through the epoxy ether intermediate of erythromycin-9-oxime, followed by opening of the epoxy linkage through various amines, whereas esters have been prepared through DCC mediated protocol. These derivatives have been evaluated for antibacterial activity and found to be as active as erythromycin-A. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.05.011