Flosequinan sulfide | 76568-23-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Flosequinan sulfide
• 英文别名: 7-fluoro-1-methyl-3-methylthio-4-quinolone；7-Fluoro-1-methyl-3-methylsulfanylquinolin-4-one
• CAS: 76568-23-5
• 化学式: C₁₁H₁₀FNOS
• 分子量: 223.271
• InChiKey: PDOYKCJODSQLCN-UHFFFAOYSA-N

物化性质

• 沸点：
  333.1±42.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Flosequinan sulfide 生成 氟司喹南
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  氟司喹南 在 三苯基膦 作用下， 以 四氯化碳 为溶剂， 反应 1.0h， 以88%的产率得到Flosequinan sulfide
  参考文献：
  名称：

  Birch, Alan M.; Davies, Roy V.; Maclean, Lachlan, Journal of the Chemical Society. Perkin transactions I, 1994, # 4, p. 387 - 392

  摘要：

  DOI：

文献信息

• 4-Quinolinones having antihypertensive activity
  申请人：The Boots Company Limited

  公开号：US04302460A1

  公开（公告）日：1981-11-24

  Compositions which contain a quinolone compound of the general formula ##STR1## wherein n is 0, 1 or 2; R.sub.1 is lower alkyl optionally substituted by hydroxy or C.sub.1-4 alkoxycarbonyl; allyl; propynyl or phenyl- lower alkyl in which the phenyl ring is optionally substituted by 1 or 2 C.sub.1-4 alkoxy groups; R.sub.2 is C.sub.1-4 alkyl with the proviso that when n is 0, R.sub.2 is methyl; and R.sub.3, R.sub.4 and R.sub.5, which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, lower alkanoyl, halo, trifluoromethyl or lower alkylthio show antihypertensive activity. Compounds of general formula ##STR2## in which n, R.sub.1 R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as described above are novel subject to the following provisos (a) when R.sub.3, R.sub.4 and R.sub.4 and R.sub.5 are hydrogen R.sub.2 is methyl and R.sub.1 is lower alkyl, R.sub.1 contains more than one carbon atom, and (b) when R.sub.3 and R.sub.4 are hydrogen, R.sub.5 is hydrogen or 7-methyl, and R.sub.1 is ethyl, R.sub.2 contains more than one carbon atom. The specification describes and claims methods of making the compounds and novel intermediates used in such methods.

  这个段落描述了含有喹诺酮化合物的组合物，其一般公式为##STR1##其中n为0、1或2；R.sub.1为可选择地被羟基或C.sub.1-4烷氧羰基取代的低烷基；烯丙基；丙炔基或苯基-低烷基，其中苯环可选择地被1或2个C.sub.1-4烷氧基取代；R.sub.2为C.sub.1-4烷基，但当n为0时，R.sub.2为甲基；R.sub.3、R.sub.4和R.sub.5，可能相同也可能不同，为氢、低烷基、低烷氧基、低烷酰基、卤素、三氟甲基或低烷硫基，显示抗高血压活性。一般公式为##STR2##中的化合物，其中n、R.sub.1、R.sub.2、R.sub.3、R.sub.4和R.sub.5如上所述，根据以下条件是新颖的：(a)当R.sub.3、R.sub.4和R.sub.5为氢时，R.sub.2为甲基，R.sub.1为低烷基，R.sub.1含有多于一个碳原子；(b)当R.sub.3和R.sub.4为氢时，R.sub.5为氢或7-甲基，R.sub.1为乙基，R.sub.2含有多于一个碳原子。该说明书描述和声称了制备这些化合物和用于这些方法的新颖中间体的方法。
• Treatment of cardiovascular disease with quinolinone enantiomers
  申请人：R.T. Alamo Ventures I, L.L.C.

  公开号：US20020143031A1

  公开（公告）日：2002-10-03

  The present invention is directed to compositions and methods for treating cardiovascular disease. In a preferred embodiment, the present invention contemplates using the enantiomers of flosequinan (and formulations comprising flosequinan) in subjects not concurrently treated with nitrites or nitrates.

  本发明涉及用于治疗心血管疾病的组合物和方法。在一个优选实施例中，本发明考虑在未同时接受硝酸盐或硝酸酯治疗的受试者中使用氟斯奎南的对映体（以及含有氟斯奎南的配方）。
• Process for the preparation of 1-methyl-3-methylthio-4-quinolone and the
  申请人：The Boots Company PLC

  公开号：US05011931A1

  公开（公告）日：1991-04-30

  A process to prepare compounds of formula I ##STR1## in which n=0, 1 or 2 comprising the cyclisation of compounds of formula II ##STR2## in which n=0, 1 or 2. The cyclisation may be effected in the presence of an organic or inorganic base or thermally at a temperature in the range 40.degree.-160.degree. C. Compounds of formula II and certain analogues thereof are disclosed as cardiovascular agents.

  一种制备化合物I的过程，其中n=0、1或2，包括将化合物II环化的步骤，其中n=0、1或2。环化可以在有机或无机碱的存在下或在40-160摄氏度范围内热处理的条件下进行。化合物II及其某些类似物被披露为心血管药物。
• CHLORINATED HETEROCYCLIC COMPOUNDS AND METHODS OF SYNTHESIS
  申请人：R.T. Alamo Ventures I, LLC

  公开号：US20030166677A1

  公开（公告）日：2003-09-04

  Compositions of the present invention comprise chlorinated heterocyclic compounds, including racemic monochloroflosequinan, purified enantiomers of monochloroflosequinan and the sulfone derivative of monochloroflosequinan. The methods of the present invention comprise the synthesis of racemic monochloroflosequinan and derivatives thereof, including the sulfone derivative. Intermediates in the synthesis are also provided. The methods further comprise the synthesis of enantiomers of monochloroflosequinan.

  本发明的组合物包括氯代杂环化合物，包括外消旋单氯葡萄糖喹啉、单氯葡萄糖喹啉的纯对映体和单氯葡萄糖喹啉的磺酰基衍生物。本发明的方法包括合成外消旋单氯葡萄糖喹啉及其衍生物的方法，包括磺酰基衍生物。本方法还提供了合成中间体的方法。本方法进一步包括合成单氯葡萄糖喹啉的对映体的方法。
• Use of halogenated heterocyclic compounds in the treatment of sexual dysfunction and cardiovascular disease
  申请人：R.T. Alamo Ventures I, LLC

  公开号：US20030191152A1

  公开（公告）日：2003-10-09

  The present invention described the administration of halogenated flosequinan derivatives and the enantiomers of halogenated flosequinan derivatives for the treatment of sexual dysfunction (in males and females) and for the treatment of cardiovascular disease.

  本发明描述了卤代氟洛昔喃衍生物及其对显性和隐性性功能障碍（男性和女性）和心血管疾病的治疗作用。