The present invention relates to novel adenosine derivatives having the formula (I):
wherein each of R₁, R₂ and R₃, which may be the same or different, is hydrogen or a lower alkyl group; X is hydrogen, a lower alkyl group, an amino group or halogen; and Y is hydrogen or a lower alkyl group;
and pharmaceutically acceptable salt thereof. These compounds are useful as antihypertensive agents, for example, for the treatments of hypertension and various diseases caused by hypertension, such as cerebrovascular diseases, cardiopathy or renal insufficiency.
本发明涉及具有式(I)的新型
腺苷衍
生物:其中,R₁、R₂和R₃可以相同或不同,各自为氢或低级烷基;X为氢、低级烷基、
氨基或卤素;Y为氢或低级烷基;及其药学上可接受的盐。 这些化合物可用作降压药,例如,用于治疗高血压和高血压引起的各种疾病,如脑血管疾病、心脏病或肾功能不全。