8-Chloro-purine riboside

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 8-Chloro-purine riboside
• 英文别名: (2R,3R,4S,5R)-2-(8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• 化学式: C₁₀H₁₁ClN₄O₄
• 分子量: 286.675
• InChiKey: SBQWIBJZLYUFOS-JXOAFFINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  8-氯腺嘌呤核苷 在 吡啶 、 亚硝酸特丁酯 、 碳酸氢铵 作用下， 以 四氢呋喃 为溶剂， 反应 141.0h， 生成 8-Chloro-purine riboside
  参考文献：
  名称：

  Synthesis and Biologic Evaluation of 8-Substituted Derivatives of Nebularine (9-β-D-Ribofuranosylpurine)

  摘要：

  A series of 8-substituted purine ribonucleosides were prepared from 2',3',5'-tri-O-acetyl-8-bromoadenosine and evaluated for cytotoxicity and antiviral activity. Four of these nucleosides (6b-9b) were significantly toxic to both HEp-2 and L1210 cells in culture but the most cytotoxic one (9b) was inactive against the P388 leukemia in mice. None of these nucleosides showed significant antiviral activity against Herpes Simplex 1 or 2, vaccinia, or influenza A.

  DOI：

  10.1080/15257779408011875

文献信息

• Novel adenosine derivatives and pharmaceutical compositions containing them as an active ingredient
  申请人：NIPPON ZOKI PHARMACEUTICAL CO. LTD.

  公开号：EP0269574A2

  公开（公告）日：1988-06-01

  The present invention relates to novel adenosine derivatives having the formula (I): wherein each of R₁, R₂ and R₃, which may be the same or different, is hydrogen or a lower alkyl group; X is hydrogen, a lower alkyl group, an amino group or halogen; and Y is hydrogen or a lower alkyl group; and pharmaceutically acceptable salt thereof. These compounds are useful as antihypertensive agents, for example, for the treatments of hypertension and various diseases caused by hypertension, such as cerebrovascular diseases, cardiopathy or renal insufficiency.

  本发明涉及具有式(I)的新型腺苷衍生物：其中，R₁、R₂和R₃可以相同或不同，各自为氢或低级烷基；X为氢、低级烷基、氨基或卤素；Y为氢或低级烷基；及其药学上可接受的盐。 这些化合物可用作降压药，例如，用于治疗高血压和高血压引起的各种疾病，如脑血管疾病、心脏病或肾功能不全。
• SHORTNACY, ANITA T.;MONTGOMERY, JOHN A.;SECRIST, JOHN A. (III), NUCLEOSIDES AND NUCLEOTIDES, 8,(1989) N-6, C. 911--913
  作者：SHORTNACY, ANITA T.、MONTGOMERY, JOHN A.、SECRIST, JOHN A. (III)

  DOI：——

  日期：——