二(1,1,1,3,3,3,-六氟异丙氧基)-甲烷 | 194039-81-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 二(1,1,1,3,3,3,-六氟异丙氧基)-甲烷
• 英文名称: formaldehyde di[2,2,2-trifluoro-1-(trifluoromethyl)ethyl] acetal
• 英文别名: formaldehyde di[2,2,2-trifluoro-1-(trifluoromethyl)ethyl]acetal；di(1,1,1,3,3,3-hexafluoroisopropyl)acetal；Propane, 2,2'-[methylenebis(oxy)]bis[1,1,1,3,3,3-hexafluoro-；1,1,1,3,3,3-hexafluoro-2-(1,1,1,3,3,3-hexafluoropropan-2-yloxymethoxy)propane
• CAS: 194039-81-1
• 化学式: C₇H₄F₁₂O₂
• 分子量: 348.088
• InChiKey: OHHWIUWMPLFBMA-UHFFFAOYSA-N

物化性质

• 沸点：
  138.0±35.0 °C(Predicted)
• 密度：
  1.560±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 二(1,1,1,3,3,3,-六氟异丙氧基)-甲烷 在 氯化亚砜 、 硫酸 作用下， 以100%的产率得到2-(氯甲氧基)-1,1,1,3,3,3-六氟丙烷
  参考文献：
  名称：

  PROCESS FOR THE PREPARATION OF CHLOROMETHYL 2,2,2-TRIFLUORO-1-(TRIFLUOROMETHYL) ETHYL ETHER

  摘要：

  本发明涉及一种制备氯甲基2,2,2-三氟-1-(三氟甲基)乙醚（sevochlorane）的方法，包括将六氟异丙醇与以下物质反应：选择自聚甲醛或1,3,5-三噁烷的甲醛等效物、从草酰氯、三氯化磷、五氯化磷、氯氧化磷、亚磺酰氯和硫酰氯组成的氯化试剂，以及从浓硫酸或烟雾硫酸组成的强酸。该方法提供高纯度和高收率的sevochlorane，可以通过已知手段转化为sevoflurane。

  公开号：

  US20100004490A1
• 作为产物：
  描述：

  六氟异丙醇 、 七氟烷 生成 二(1,1,1,3,3,3,-六氟异丙氧基)-甲烷
  参考文献：
  名称：

  [EN] STABLE PHARMACEUTICAL COMPOSITION OF FLUOROETHER COMPOUND FOR ANESTHETIC USE, METHOD FOR STABILIZING A FLUOROETHER COMPOUND, USE OF STABILIZER AGENT FOR PRECLUDING THE DEGRADATION OF A FLUOROETHER COMPOUND
  [FR] COMPOSITION PHARMACEUTIQUE STABLE D'UN COMPOSE DE FLUOROETHER A USAGE ANESTHESIQUE, METHODE DE STABILISATION D'UN COMPOSE DE FLUOROETHER, UTILISATION D'UN AGENT STABILISANT DANS LA PREVENTION DE LA DEGRADATION D'UN COMPOSE DE FLUOROETHER

  摘要：

  公开号：

  WO2005023175A3

文献信息

• [EN] FLUORINATED ELECTROLYTE ADDITIVES<br/>[FR] ADDITIFS D'ÉLECTROLYTE FLUORÉ
  申请人：E3TRIGEN INC

  公开号：WO2021055560A1

  公开（公告）日：2021-03-25

  The disclosure relates to the use of fluorinated ethers such as 1,1, 1,3,3,3-hexafluoro-2-methoxypropane (HFMOP) as a reaction solvent to prepare fluorinated dialkyl carbonate and sulfite compounds useful in batteries, and to electrolytes containing fluorinated compounds for use in batteries containing high Ni cathodes and silicon containing anodes.

  该公开涉及使用氟化醚，如1,1,1,3,3,3-六氟-2-甲氧基丙烷（HFMOP）作为反应溶剂，用于制备用于电池的氟化二烷基碳酸酯和亚硫酸盐化合物，并用于含有高镍阴极和含硅阳极的电池中的含氟化合物的电解质。
• Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis
  申请人：Baxter International Inc

  公开号：US20040147779A1

  公开（公告）日：2004-07-29

  Provided is a process of obtaining 1,1,1,3,3,3-hexafluoro-2-propanol (“HFIP”) from a composition comprising an HFIP hydrolyzable precursor. The HFIP hydrolyzable precursor is a compound, other than sevoflurane itself, that has an intact 1,1,1,3,3,3-hexafluoroisopropoxy moiety[(CF 3 ) 2 CHO—], and contains one or more moieties susceptible to acidic hydrolysis, such that HFIP is released upon such treatment. The process is useful, among other things, for recovering HFIP from waste streams associated with the synthesis of the inhalation anesthetic, fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (“sevoflurane”). The process includes heating the composition with a strong protic acid to a temperature effective to hydrolyze at least some of the HFIP hydrolyzable precursor to HFIP, and then isolating the HFIP from the heated composition.

  提供了一种从含有HFIP水解前体的组成物中获取1,1,1,3,3,3-六氟-2-丙醇（“HFIP”）的过程。HFIP水解前体是一种化合物，除了七氟醚本身外，具有完整的1,1,1,3,3,3-六氟异丙氧基基团（（CF3）2CHO-），并含有一种或多种易于酸性水解的基团，因此在这种处理下释放HFIP。该过程可用于从与吸入麻醉剂氟甲基2,2,2-三氟-1-（三氟甲基）乙基醚（“七氟醚”）的合成相关的废水中回收HFIP。该过程包括将组成物与强质子酸加热到有效的温度以水解至少一部分HFIP水解前体为HFIP，然后从加热的组成物中分离出HFIP。
• Stable pharmaceutical composition of fluoroether compound for anesthetic use method for stabilizing a fluoroether compound, use of stabilizer agent for precluding the degradation of a fluoroether compound
  申请人：Pacheco Ogari

  公开号：US20060228383A1

  公开（公告）日：2006-10-12

  The present invention has as objective the stabilization of a fluoroether compound against degradation by acid substances. The stabilizers proposed are selected among propylene glycol, polyethylene glycol, hexylene glycol, 1,3-butylene glycol and a saturated cyclic alcohol preferably menthol and are used for preparing stable pharmaceutical compositions of a fluoroether compound. Method for stabilizing a fluoroether compound and use of stabilizers agents for precluding the degradation of a fluoroether are also described.

  本发明的目的是使氟醚化合物稳定不受酸性物质的降解。所提出的稳定剂包括丙二醇、聚乙二醇、己二醇、1,3-丁二醇和饱和环醇，最好是薄荷醇，并用于制备稳定的氟醚化合物的制药组合物。还描述了稳定氟醚化合物的方法和使用稳定剂代理来防止氟醚的降解。
• Method of producing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether
  申请人：Central Glass Co., Ltd.

  公开号：US05811596A1

  公开（公告）日：1998-09-22

  The present invention provides a novel method of producing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether. It is a method of producing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether by bringing a polyether represented by the following general formula (1) into contact with a medium comprising hydrogen fluoride and an accelerant, R.sup.1 O(CH.sub.2 O).sub.n R.sup.2 ( 1) where R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1 -C.sup.10 alkyl or haloalkyl groups, where halogen is fluorine, chlorine or bromine, n is an integer of from 1 to 10, and both of R.sup.1 and R.sup.2 are not hydrogen at the same time.

  本发明提供了一种生产氟甲基1,1,1,3,3,3-六氟异丙醚的新方法。该方法是通过将以下通式（1）表示的聚醚与含氢氟酸和催化剂的介质接触来生产氟甲基1,1,1,3,3,3-六氟异丙醚，其中R.sup.1 O(CH.sub.2 O).sub.n R.sup.2，式中R.sup.1和R.sup.2独立地表示氢、C.sub.1-C.sup.10烷基或卤代烷基，其中卤素为氟、氯或溴，n为1至10的整数，并且R.sup.1和R.sup.2不能同时为氢。
• PROCESS FOR THE PREPARATION OF FLUOROMETHYL 2,2,2-TRIFLUORO-1-(TRIFLUOROMETHYL) ETHYL ETHER
  申请人：Pacheco Ogari

  公开号：US20090247791A1

  公开（公告）日：2009-10-01

  The present invention refers to a process for the preparation of fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (sevoflurane) which includes a step that consists of reacting hexafluoroisopropanol with a formaldehyde equivalent selected among paraformaldehyde or 1,3,5-trioxane, a chlorinating agent selected from the group consisting of oxalyl chloride, phosphorus trichloride, phosphorus pentachloride, phosphorus oxychloride, sulfuryl chloride and thionyl chloride, and a strong acid selected from the group consisting of concentrated or fuming sulfuric acid resulting in the formation of the intermediate sevochlorane which is converted to sevoflurane in a second step which consists of reacting sevochlorane with an alkali metal fluoride, or a linear or branched chain tetra-alkyl quarternary ammonium fluoride in the presence of a sub-stoichiometric quantity of an alkali metal iodide, or a linear or branched alkyl chain tetra-alkyl quarternary ammonium iodide, preferably in a solvent.

  本发明涉及一种制备氟甲基2,2,2-三氟-1-（三氟甲基）乙基醚（七氟醚）的方法，其中包括以下步骤：将六氟异丙醇与选择自聚甲醛或1,3,5-三噁烷的甲醛等效物、从草酰氯、三氯化磷、五氯化磷、氧化亚磷、氯化亚磷酰和亚磺酰氯的组中选择的氯化剂和从浓硫酸或烟雾硫酸中选择的强酸反应，形成中间体七氟氯烷，然后在第二步中将七氟氯烷与碱金属氟或线性或支链四烷基季铵氟在亚化学计量量的碘化金属或线性或支链烷基四烷基季铵碘的存在下反应，优选在溶剂中进行，从而转化为七氟醚。