2-溴-3,4-二羟基-5-甲氧基苯甲酸 | 143883-73-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-溴-3,4-二羟基-5-甲氧基苯甲酸
• 英文名称: 2-bromo-5-O-methyl gallic acid
• 英文别名: 2-Bromo-3,4-dihydroxy-5-methoxybenzoic acid
• CAS: 143883-73-2
• 化学式: C₈H₇BrO₅
• 分子量: 263.045
• InChiKey: FKXVJJUTKUVGFG-UHFFFAOYSA-N

物化性质

• 沸点：
  414.2±45.0 °C(Predicted)
• 密度：
  1.892±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-溴-3,4-二羟基-5-甲氧基苯甲酸 在 potassium fluoride 、 硫酸 、 铜 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 11.67h， 生成 联苯双酯
  参考文献：
  名称：

  Synthesis and antihepatotoxicity of some Wuweizisu analogues

  摘要：

  A preparation of dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (VII) was readily achieved. It provided the advantages of specificity, simplicity, and efficiency in reactions. 6-Phenyl-3,9-dimethoxy-1,2-methylene-dioxy-10,11-methylenedioxy-6,7-dihydro-5H-dibenz(c, e)azepin (X) was successfully synthesized from VII (DDB) and its liver-protective property proved to be more effective than DDB and silymarin in the in vitro test of carbon tetrachloride-induced damage of primary cultured rat hepatocytes.

  DOI：

  10.1016/0223-5234(92)90148-t
• 作为产物：
  描述：

  3-O-甲基没食子酸 在 溴 、 二溴甲烷 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 5.0h， 以74%的产率得到2-溴-3,4-二羟基-5-甲氧基苯甲酸
  参考文献：
  名称：

  Synthesis and antihepatotoxicity of some Wuweizisu analogues

  摘要：

  A preparation of dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (VII) was readily achieved. It provided the advantages of specificity, simplicity, and efficiency in reactions. 6-Phenyl-3,9-dimethoxy-1,2-methylene-dioxy-10,11-methylenedioxy-6,7-dihydro-5H-dibenz(c, e)azepin (X) was successfully synthesized from VII (DDB) and its liver-protective property proved to be more effective than DDB and silymarin in the in vitro test of carbon tetrachloride-induced damage of primary cultured rat hepatocytes.

  DOI：

  10.1016/0223-5234(92)90148-t

文献信息

• Synthesis and antihepatotoxicity of some Wuweizisu analogues
  作者：WL Wu、SE Chen、WL Chang、CF Chen、AR Lee

  DOI：10.1016/0223-5234(92)90148-t

  日期：1992.6

  A preparation of dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (VII) was readily achieved. It provided the advantages of specificity, simplicity, and efficiency in reactions. 6-Phenyl-3,9-dimethoxy-1,2-methylene-dioxy-10,11-methylenedioxy-6,7-dihydro-5H-dibenz(c, e)azepin (X) was successfully synthesized from VII (DDB) and its liver-protective property proved to be more effective than DDB and silymarin in the in vitro test of carbon tetrachloride-induced damage of primary cultured rat hepatocytes.