3,4,6,7-tetrahydro-9-(1,2-dihydro-2-oxoquinolin-3-yl)-3,3,6,6-tetramethyl-2H-xanthene-1,8(5H,9H)-dione | 312514-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3,4,6,7-tetrahydro-9-(1,2-dihydro-2-oxoquinolin-3-yl)-3,3,6,6-tetramethyl-2H-xanthene-1,8(5H,9H)-dione
• 英文别名: 3,3,6,6-tetramethyl-9-(2-oxo-1,2-dihydroquinolin-3-yl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione；9-(2-hydroxyquinolin-3-yl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-dione
• CAS: 312514-75-3
• 化学式: C₂₆H₂₇NO₄
• mdl: MFCD01572660
• 分子量: 417.505
• InChiKey: LHIAKCSGISANTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  31
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯-3-喹啉甲醛 、 5,5-二甲基-1,3-环己二酮 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以89%的产率得到3,4,6,7-tetrahydro-9-(1,2-dihydro-2-oxoquinolin-3-yl)-3,3,6,6-tetramethyl-2H-xanthene-1,8(5H,9H)-dione
  参考文献：
  名称：

  Efficient Synthesis and Evaluation of Antitumor Activities of Novel Functionalized 1,8-Naphthyridine Derivatives

  摘要：

  An efficient synthesis of novel functionalized 1,8-naphthyridine and chromeno[2,3-b]quinoline derivatives via cascade reaction of 2-chloroquinoline-3-carbaldehyde and enaminones or cyclic 1,3-dicarbonyl compounds was developed. All of the 1,8-naphthyridine derivatives synthesized were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have high activities.

  DOI：

  10.1021/co500120b

文献信息

• Water mediated catalyst-free efficient domino synthesis of 9-(quinolin-2(1H)-one)-xanthene-1,8(5H,9H)-diones using parallel synthesizer
  作者：Varadhan Krishnakumar、Badal Kumar Mandal、Fazlur-Rahman Nawaz Khan、Euh Duck Jeong

  DOI：10.1016/j.tetlet.2014.05.015

  日期：2014.7