Pyrimido[4,5-b]quinolin-2-ol | 189765-09-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Pyrimido[4,5-b]quinolin-2-ol
• 英文别名: 1H,2H-Pyrimido[4,5-B]quinolin-2-one；1H-pyrimido[4,5-b]quinolin-2-one
• CAS: 189765-09-1
• 化学式: C₁₁H₇N₃O
• mdl: MFCD24390764
• 分子量: 197.196
• InChiKey: RSOUYDHGTVTMCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氯-3-喹啉甲醛 、 尿素 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以80%的产率得到Pyrimido[4,5-b]quinolin-2-ol
  参考文献：
  名称：

  Synthesis of some novel substituted quinolines as potent analgesic agents

  摘要：

  2-Chloroquinoline-3-carbaldehyde and 2-chloro-4-methylquinoline-3-carbaldehyde have been prepared from acetanilide and acetoacetanilide via a Vilsmeier--Haack reaction. Upon reaction with phenyl hydrazine, hydroxylamine, urea, and thiourea in presence of acetic acid, these chloroaldehydes afforded the title compounds which exhibit a several times higher analgesic activity than noramidopyrine (NAP).

  DOI：

  10.1007/bf00807642

文献信息

• Solvent free microwave synthesis and evaluation of antimicrobial activity of pyrimido[4,5-b]- and pyrazolo[3,4-b]quinolines
  作者：Senniappan Thamarai Selvi、Vetrivel Nadaraj、Sellappan Mohan、Raju Sasi、Manoharan Hema

  DOI：10.1016/j.bmc.2006.01.048

  日期：2006.6

  A series of 2-oxopyrimido[4,5-b]-, 2-thio[4,5-b]-, 1-(p-tosyl)pyrazolo[3,4-b]- and 1-(2',4'-dinitropheiiyl)pyrazolo[3,4-b]-quinolines have been synthesized in good to excellent yields by environmentally benign solvent free microwave-induced techniques involving the condensation of 2-chloro-3-formylquinolines with urea, thiourea, p-toluenesulfonylhydrazide and 2,4-dinitrophenylhydrazine, respectively, using PTSA as a catalyst. All the synthesized compounds were evaluated for their antibacterial and antifungal activities. Most of the compounds showed the best activity against Escherichia coli and Pseudomonas aeruginosa. (c) 2006 Elsevier Ltd. All rights reserved.