N-benzylquinoline-6-carboxamide | 6843-60-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-benzylquinoline-6-carboxamide
• 英文别名: N-Benzyl-chinolin-6-carbonsaeure-amid；quinoline-6-carboxylic acid benzylamide；6-benzylaminocarbonyl-quinoline；N-benzyl-6-quinoline carboxamide
• CAS: 6843-60-3
• 化学式: C₁₇H₁₄N₂O
• 分子量: 262.311
• InChiKey: CDWXGJNNZJGLPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  喹啉-6-羧酸 、 苄胺 在 吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 反应 1.5h， 生成 N-benzylquinoline-6-carboxamide
  参考文献：
  名称：

  WO2008/126684

  摘要：

  公开号：

文献信息

• Highly Selective Synthesis of 6-Glyoxylamidoquinoline Derivatives via Palladium-Catalyzed Aminocarbonylation
  作者：Sami Chniti、László Kollár、Attila Bényei、Attila Takács

  DOI：10.3390/molecules27010004

  日期：——

  XantPhos, the quinoline-6-carboxamide derivatives were synthesized almost exclusively under atmospheric conditions (up to 98%). The isolation and characterization of the new carbonylated products of various structures were also accomplished. Furthermore, the structure of three new mono- and double-carbonylated compounds were unambiguously established by using a single-crystal XRD study.

  已经在大量胺亲核试剂存在下研究了 6-碘喹啉的氨基羰基化，为生产各种喹啉-6-甲酰胺和喹啉-6-乙醛酰胺衍生物提供了有效的合成途径。经过详细的优化研究表明，酰胺和酮酰胺的形成受到反应条件的强烈影响。在 Pd(OAc) 2 /2 PPh 3存在下在 40 bar 的一氧化碳压力下进行反应，相应的 2-酮甲酰胺作为主要产物形成（高达 63%）。当单齿三苯基膦被双齿 XantPhos 取代时，喹啉-6-甲酰胺衍生物几乎完全在大气条件下合成（高达 98%）。还完成了各种结构的新羰基化产物的分离和表征。此外，通过使用单晶 XRD 研究，明确地确定了三种新的单羰基化和双羰基化化合物的结构。
• [EN] SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS<br/>[FR] DÉRIVÉS DE 8-HYDROXYQUINOLINE-7-CARBOXAMIDE SECONDAIRES ET LEURS UTILISATIONS EN TANT QU'AGENTS ANTIFONGIQUES
  申请人：POLICHEM SA

  公开号：WO2011080265A1

  公开（公告）日：2011-07-07

  The present invention provides secondary 8-hydroxyquinoiine-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulahopsis Brevicaulis. These compounds are active against Candida species such as Candida Albicans and Candida Glabrata.

  本发明提供了一般式（I）的二级8-羟基喹啉-7-羧酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体来说，这些化合物已经对Tricophyton Rubrum，Tricophyton Mentagrophytes，Aspergillus Niger和Scopulahopsis Brevicaulis进行了测试。这些化合物对Candida Albicans和Candida Glabrata等念珠菌物种具有活性。
• [EN] NEW SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES.<br/>[FR] NOUVEAUX DÉRIVÉS DE 8-HYDROXYQUINOLINE-7-CARBOXAMIDE SECONDAIRES
  申请人：POLICHEM SA

  公开号：WO2011080266A1

  公开（公告）日：2011-07-07

  The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopuiariopsis Brevicaulis. Many of these compounds are active against Candida species such as Candida Albicans and Candida Glabrata.

  本发明提供了一种新的通式（I）的次级8-羟基喹啉-7-羧酰胺衍生物及其药物可接受的盐。这些化合物可用作抗真菌剂。具体而言，这些化合物已经对红色毛癣菌、鼠癣菌、黑曲霉和短柄镰刀菌进行了测试。这些化合物中的许多对白色念珠菌如白色念珠菌和光滑念珠菌等具有活性。
• AGRICULTURAL COMPOSITION FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENIC MICROBES
  申请人：Takaishi Masanao

  公开号：US20100041694A1

  公开（公告）日：2010-02-18

  An agricultural composition comprising an amide compound represented by the following formula (I), a salt thereof, or a hydrate thereof is effective for controlling or preventing plant diseases caused by plant pathogenic microbes when an effective amount of the agricultural composition is applied to useful crops.

  应用以下式（I）所表示的酰胺化合物、其盐或水合物的农业组合物，在对有用作物施用有效量的农业组合物时，对于控制或预防由植物病原微生物引起的植物病害是有效的。
• SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES
  申请人：Gagliardi Stefania

  公开号：US20120316167A1

  公开（公告）日：2012-12-13

  The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis . Many of these compounds are active against Candida species such as Candida Albicans and Candida Glabrata .

  本发明提供了新的通式（I）的二次8-羟基喹啉-7-羧酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体地，这些化合物已经对Tricophyton Rubrum，Tricophyton Mentagrophytes，Aspergillus Niger和Scopulariopsis Brevicaulis进行了测试。其中许多化合物对Candida Albicans和Candida Glabrata等Candida物种具有活性。