6-{[3-(trifluoromethyl)phenyl]amino}-3,4-dihydroquinolin-2(1H)-one | 1232100-46-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-{[3-(trifluoromethyl)phenyl]amino}-3,4-dihydroquinolin-2(1H)-one
• 英文别名: 6-[3-(Trifluoromethyl)phenylamino]-1,2,3,4-tetrahydroquinoline-2-one；6-[3-(trifluoromethyl)anilino]-3,4-dihydro-1H-quinolin-2-one
• CAS: 1232100-46-7
• 化学式: C₁₆H₁₃F₃N₂O
• 分子量: 306.287
• InChiKey: NWKSMUGLLMMCKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-{[3-(trifluoromethyl)phenyl]amino}-3,4-dihydroquinolin-2(1H)-one 在 氧气 、 palladium diacetate 作用下， 以 溶剂黄146 为溶剂， 反应 8.0h， 以52%的产率得到8-trifluoromethyl-3,4-dihydro-1H-pyrido[3,2-b]carbazol-2(6H)-one
  参考文献：
  名称：

  Structure–Activity Relationships of Carboline and Carbazole Derivatives as a Novel Class of ATP-Competitive Kinesin Spindle Protein Inhibitors

  摘要：

  The kinesin spindle protein (KSP) is a mitotic kinesin involved in the establishment of a functional bipolar mitotic spindle during cell division. It is considered to be an attractive target for cancer chemotherapy with reduced side effects. Based on natural product scaffold-derived fused indole-based inhibitors and known biphenyl-type KSP inhibitors, various carboline and carbazole derivatives were synthesized and biologically evaluated. beta-Carboline and lactam-fused carbazole derivatives exhibited remarkably potent KSP inhibitory activity and mitotic arrest in prometaphase with formation of an irregular monopolar spindle. The planar tri- and tetracyclic analogs inhibited KSP ATPase in an ATP-competitive manner just like biphenyl-type inhibitors.

  DOI：

  10.1021/jm200448n
• 作为产物：
  描述：

  6-溴-1,2,3,4-四氢-2-喹啉酮 、 间氨基三氟甲苯 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 sodium t-butanolate 、 2-二环己膦基-2'-(N,N-二甲胺)-联苯 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以62%的产率得到6-{[3-(trifluoromethyl)phenyl]amino}-3,4-dihydroquinolin-2(1H)-one
  参考文献：
  名称：

  Structure–Activity Relationships of Carboline and Carbazole Derivatives as a Novel Class of ATP-Competitive Kinesin Spindle Protein Inhibitors

  摘要：

  The kinesin spindle protein (KSP) is a mitotic kinesin involved in the establishment of a functional bipolar mitotic spindle during cell division. It is considered to be an attractive target for cancer chemotherapy with reduced side effects. Based on natural product scaffold-derived fused indole-based inhibitors and known biphenyl-type KSP inhibitors, various carboline and carbazole derivatives were synthesized and biologically evaluated. beta-Carboline and lactam-fused carbazole derivatives exhibited remarkably potent KSP inhibitory activity and mitotic arrest in prometaphase with formation of an irregular monopolar spindle. The planar tri- and tetracyclic analogs inhibited KSP ATPase in an ATP-competitive manner just like biphenyl-type inhibitors.

  DOI：

  10.1021/jm200448n

文献信息

• Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors
  作者：Tomoki Takeuchi、Shinya Oishi、Masato Kaneda、Ryosuke Misu、Hiroaki Ohno、Jun-ichi Sawada、Akira Asai、Shinya Nakamura、Isao Nakanishi、Nobutaka Fujii

  DOI：10.1016/j.bmc.2014.04.008

  日期：2014.6

  Structure-activity relationship studies of diaryl amine-type KSP inhibitors were carried out. Diaryl amine derivatives with a pyridine ring or urea group were less active when compared with the parent carboline and carbazole derivatives. Optimization studies of a lactam-fused diphenylamine-type KSP inhibitor revealed that the aniline NH group and 3-CF3 phenyl group were indispensable for potent KSP inhibition. Modification with a seven-membered lactam-fused phenyl group and a 4-(trifluoromethyl)pyridin-2-yl group improved aqueous solubility while maintaining potent KSP inhibitory activity. From these studies, we identified novel diaryl amine-type KSP inhibitors with a favorable balance of potency and solubility. (C) 2014 Elsevier Ltd. All rights reserved.
• [EN] Eg5 INHIBITOR<br/>[FR] INHIBITEUR D'Eg5
  申请人：UNIV KYOTO

  公开号：WO2014174745A1

  公开（公告）日：2014-10-30

  　本発明の水溶性多環性化合物又はその薬理学的に許容される塩は、従来のＥｇ５（ＫＳＰ：キネシンスピンドルタンパク質）阻害剤と比較して、水性溶媒に対して大きな溶解度を有し、且つ従来のＥｇ５阻害剤と同等若しくはそれ以上のＥｇ５阻害活性を有する。さらに、これらの特性により種々の癌細胞に対し顕著な成長阻害活性を有し、癌等の治療に非常に有効である。
• Structure–Activity Relationships of Carboline and Carbazole Derivatives as a Novel Class of ATP-Competitive Kinesin Spindle Protein Inhibitors
  作者：Tomoki Takeuchi、Shinya Oishi、Toshiaki Watanabe、Hiroaki Ohno、Jun-ichi Sawada、Kenji Matsuno、Akira Asai、Naoya Asada、Kazuo Kitaura、Nobutaka Fujii

  DOI：10.1021/jm200448n

  日期：2011.7.14

  The kinesin spindle protein (KSP) is a mitotic kinesin involved in the establishment of a functional bipolar mitotic spindle during cell division. It is considered to be an attractive target for cancer chemotherapy with reduced side effects. Based on natural product scaffold-derived fused indole-based inhibitors and known biphenyl-type KSP inhibitors, various carboline and carbazole derivatives were synthesized and biologically evaluated. beta-Carboline and lactam-fused carbazole derivatives exhibited remarkably potent KSP inhibitory activity and mitotic arrest in prometaphase with formation of an irregular monopolar spindle. The planar tri- and tetracyclic analogs inhibited KSP ATPase in an ATP-competitive manner just like biphenyl-type inhibitors.