1-Cyclopentenyl-isopentyl-keton | 38136-31-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Cyclopentenyl-isopentyl-keton
• 英文别名: 1-(Cyclopenten-1-yl)-4-methylpentan-1-one
• CAS: 38136-31-1
• 化学式: C₁₁H₁₈O
• 分子量: 166.263
• InChiKey: AVRISRDQBSBFIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Cyclopentenyl-isopentyl-keton 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成 Cyclopentyl-3-methyl-but-1-yl-keton
  参考文献：
  名称：

  Photochemical reactions of 1-cyclopentenyl and 1-cyclohexenyl ketones

  摘要：

  DOI：

  10.1021/ja00787a041
• 作为产物：
  描述：

  异己酰氯 、 环戊烯 在 三氯化铝 作用下， 以 二氯甲烷 为溶剂， 生成 1-Cyclopentenyl-isopentyl-keton
  参考文献：
  名称：

  Photochemical reactions of 1-cyclopentenyl and 1-cyclohexenyl ketones

  摘要：

  DOI：

  10.1021/ja00787a041

文献信息

• Compositions and methods for treating cancer
  申请人：The Regents of the University of California

  公开号：US10023588B2

  公开（公告）日：2018-07-17

  K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.

  K-Ras 是人类癌症中最常见的突变癌基因。本文公开了调节 K-Ras 和治疗癌症的组合物和方法。
• Thiazolyl-containing compounds for treating proliferative diseases
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US10464949B2

  公开（公告）日：2019-11-05

  The present disclosure provides thiazolyl-containing compounds of Formula (I), (II), or (III). The compounds described herein may be able to inhibit protein kinases (e.g., Src family kinases (e.g., hemopoietic cell kinase (HCK)), Bruton's tyrosine kinase (BTK)) and may be useful in treating and/or preventing proliferative diseases (e.g., myelodysplasia, leukemia, lymphoma (e.g., Waldenström's macroglobulinemia)) and in inducing apoptosis in a cell (e.g., malignant blood cell). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

  本公开提供了式(I)、(II)或(III)的含噻唑化合物。本文所述化合物可抑制蛋白激酶（如 Src 家族激酶（如造血细胞激酶 (HCK)）、布鲁顿酪氨酸激酶 (BTK)），可用于治疗和/或预防增殖性疾病（如、骨髓增生异常、白血病、淋巴瘤（如瓦尔登斯特伦巨球蛋白血症））和诱导细胞（如恶性血细胞）凋亡。本公开还提供了包括或使用本文所述化合物的药物组合物、试剂盒、方法和用途。
• Heteroaryl compounds and uses thereof
  申请人：Celgene CAR LLC

  公开号：US10774052B2

  公开（公告）日：2020-09-15

  The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

  本发明提供了化合物、其药学上可接受的组合物及其使用方法。
• THIAZOLYL-CONTAINING COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20190119301A1

  公开（公告）日：2019-04-25

  The present disclosure provides thiazolyl-containing compounds of Formula (I), (II), or (III). The compounds described herein may be able to inhibit protein kinases (e.g., Src family kinases (e.g., hemopoietic cell kinase (HCK)), Bruton's tyrosine kinase (BTK)) and may be useful in treating and/or preventing proliferative diseases (e.g., myelodysplasia, leukemia, lymphoma (e.g., Waldenström's macroglobulinemia)) and in inducing apoptosis in a cell (e.g., malignant blood cell). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.
• Photochemical reactions of 1-cyclopentenyl and 1-cyclohexenyl ketones
  作者：Amos B. Smith、William C. Agosta

  DOI：10.1021/ja00787a041

  日期：1973.3