4,5-dimethyl-2-(2-nitro-phenyl)-1H-imidazole | 209251-83-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,5-dimethyl-2-(2-nitro-phenyl)-1H-imidazole
• 英文别名: 4,5-dimethyl-2-(2-nitrophenyl)-1H-imidazole
• CAS: 209251-83-2
• 化学式: C₁₁H₁₁N₃O₂
• 分子量: 217.227
• InChiKey: YOYRXJRNXGYWHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  74.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,5-dimethyl-2-(2-nitro-phenyl)-1H-imidazole 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 2,3-dimethylimidazo[1,2-c]quinazoline
  参考文献：
  名称：

  Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect

  摘要：

  A series of imidazo[1,2-c]quinazolines of different lipophilic character was prepared. According to their antioxidant (cyclic voltammetry) properties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe(2+)-induced lipid peroxidation in rat brain homogenate), however, their lipid peroxidation inhibitory activity was strongly dependent on their lipophilicity. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80007-x
• 作为产物：
  描述：

  2,3-丁二酮 、 邻硝基苯甲醛 在 ammonium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 以36.7%的产率得到4,5-dimethyl-2-(2-nitro-phenyl)-1H-imidazole
  参考文献：
  名称：

  Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect

  摘要：

  A series of imidazo[1,2-c]quinazolines of different lipophilic character was prepared. According to their antioxidant (cyclic voltammetry) properties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe(2+)-induced lipid peroxidation in rat brain homogenate), however, their lipid peroxidation inhibitory activity was strongly dependent on their lipophilicity. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80007-x