2-(4,5-dimethyl-1H-imidazol-2-yl)-aniline | 29528-26-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4,5-dimethyl-1H-imidazol-2-yl)-aniline
• 英文别名: 2-(4,5-dimethyl-1H-imidazol-2-yl)aniline
• CAS: 29528-26-5
• 化学式: C₁₁H₁₃N₃
• 分子量: 187.244
• InChiKey: CJAIYRAOZOXQGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4,5-dimethyl-1H-imidazol-2-yl)-aniline 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 2,3-dimethyl-5,6-dihydro-imidazo[1,2-c]quinazoline
  参考文献：
  名称：

  Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect

  摘要：

  A series of imidazo[1,2-c]quinazolines of different lipophilic character was prepared. According to their antioxidant (cyclic voltammetry) properties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe(2+)-induced lipid peroxidation in rat brain homogenate), however, their lipid peroxidation inhibitory activity was strongly dependent on their lipophilicity. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80007-x
• 作为产物：
  描述：

  4,5-dimethyl-2-(2-nitro-phenyl)-1H-imidazole 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 以75.4%的产率得到2-(4,5-dimethyl-1H-imidazol-2-yl)-aniline
  参考文献：
  名称：

  Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect

  摘要：

  A series of imidazo[1,2-c]quinazolines of different lipophilic character was prepared. According to their antioxidant (cyclic voltammetry) properties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe(2+)-induced lipid peroxidation in rat brain homogenate), however, their lipid peroxidation inhibitory activity was strongly dependent on their lipophilicity. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80007-x

文献信息

• METAL COMPLEXES
  申请人：Merck Patent GmbH

  公开号：US20150270500A1

  公开（公告）日：2015-09-24

  The present invention relates to metal complexes and to electronic devices, in particular organic electroluminescent devices, comprising these metal complexes.

  本发明涉及金属配合物及包括这些金属配合物的电子设备，特别是有机电致发光器件。
• METALLKOMPLEXE
  申请人：Merck Patent GmbH

  公开号：EP2906575B1

  公开（公告）日：2018-01-17
• US9831446B2
  申请人：——

  公开号：US9831446B2

  公开（公告）日：2017-11-28
• [DE] METALLKOMPLEXE<br/>[EN] METAL COMPLEXES<br/>[FR] COMPLEXES MÉTALLIQUES
  申请人：MERCK PATENT GMBH

  公开号：WO2014056564A1

  公开（公告）日：2014-04-17

  Die vorliegende Erfindung betrifft Metallkomplexe sowie elektronische Vorrichtungen, insbesondere organische Elektrolumineszenzvorrichtungen, enthaltend diese Metallkomplexe.
• Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect
  作者：György Domány、Tibor Gizur、Anikó Gere、Krisztina Takács-Novák、György Farsang、György G. Ferenczy、Gábor Tárkányi、Mária Demeter

  DOI：10.1016/s0223-5234(98)80007-x

  日期：1998.3

  A series of imidazo[1,2-c]quinazolines of different lipophilic character was prepared. According to their antioxidant (cyclic voltammetry) properties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe(2+)-induced lipid peroxidation in rat brain homogenate), however, their lipid peroxidation inhibitory activity was strongly dependent on their lipophilicity. (C) Elsevier, Paris.