[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl] N-(3,5-dimethyl-1-tetracyclo[5.2.1.03,8.05,8]decanyl)carbamate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl] N-(3,5-dimethyl-1-tetracyclo[5.2.1.03,8.05,8]decanyl)carbamate
• 化学式: C₃₃H₅₁NO₂
• 分子量: 493.8
• InChiKey: RRHLZLOWZJODNO-NEYQPTSFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.8
• 重原子数：
  36
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• GGA AND GGA DERIVATIVES COMPOSITIONS THEREOF AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES INCLUDING PARALYSIS INCLUDING THEM
  申请人：COYOTE PHARMACEUTICALS, INC.

  公开号：US20150025077A1

  公开（公告）日：2015-01-22

  This invention relates to geranylgeranyl acetone (GGA) derivatives and the use of GGA, its isomers, and GGA derivatives in methods for inhibiting neural death, increasing neural activity, increasing axon growth and cell viability, and increasing the survival rate of subjects administered the GGA or GGA derivatives.

  本发明涉及生产戊二十烯基乙酸酯（GGA）衍生物及其应用，其中GGA、其异构体和GGA衍生物用于抑制神经细胞死亡、增强神经活动、促进轴突生长和细胞存活，以及提高接受GGA或GGA衍生物的受试者的生存率的方法。
• US20140275091A1
  申请人：——

  公开号：US20140275091A1

  公开（公告）日：2014-09-18
• PREPARATION OF GGA AND DERIVATIVES THEREOF AND THEIR CO-CRYSTALLIZATION WITH UREA OR THIOUREA
  申请人：COYOTE PHARMACEUTICALS, INC.

  公开号：US20150258039A1

  公开（公告）日：2015-09-17

  Provided herein are compositions comprising co-crystals of GGA or a GGA derivative (including salts and tauotomers thereof) with urea or thiourea, and processes related to such co-crystals. Also provided herein are methods, compounds, and compositions related to preparing trans GGA and derivatives thereof, and intermediates thereto.
• US9045403B2
  申请人：——

  公开号：US9045403B2

  公开（公告）日：2015-06-02