bis-(4-methyl-[2]quinolyl)-disulfide | 66546-28-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: bis-(4-methyl-[2]quinolyl)-disulfide
• 英文别名: Bis-(4-methyl-[2]chinolyl)-disulfid；4-Methyl-2-Quinolyl Disulfide；4-methyl-2-[(4-methylquinolin-2-yl)disulfanyl]quinoline
• CAS: 66546-28-9
• 化学式: C₂₀H₁₆N₂S₂
• 分子量: 348.492
• InChiKey: PPKNKZQDYHGQFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  76.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲基喹啉-2-硫酮 在 selenium(IV) oxide 、 溶剂黄146 作用下， 生成 bis-(4-methyl-[2]quinolyl)-disulfide
  参考文献：
  名称：

  Monti; Franchi, Gazzetta Chimica Italiana, 1951, vol. 81, p. 764,768, 770

  摘要：

  DOI：

文献信息

• Method for induction of L-selectin shedding
  申请人：——

  公开号：US20030092763A1

  公开（公告）日：2003-05-15

  The invention provides anti-thiol reagents which inhibit enzyme activity of cell-associated protein disulfide isomerase (PDI) by oxidizing or blocking PDI active site vicinal thiol groups which normally participate in disulfide bond rearrangement of PDI substrates. Inhibition of this PDI function is particularly useful in blocking PDI-mediated entry of HIV or other virions into a host cell, as well as inhibiting lymphocyte traffic through the lymph nodes. The invention further provides an assay for the identification of such PDI inhibitors based on the discovery that inhibitors of the invention also induce shedding of the leucocyte L-selectin adhesion molecule. The invention additionally provides for suppression of inflammation and of lymph node entry by calmodulin antagonists that, like PDI inhibition, cause leukocyte L-selectin shedding.

  本发明提供了抗硫醇试剂，通过氧化或阻断通常参与 PDI 底物二硫键重排的 PDI 活性位点邻位硫醇基团，抑制细胞相关蛋白二硫异构酶（PDI）的酶活性。抑制 PDI 的这种功能尤其有助于阻止 PDI 介导的 HIV 或其他病毒进入宿主细胞，以及抑制淋巴细胞通过淋巴结的交通。本发明进一步提供了一种用于鉴定此类 PDI 抑制剂的检测方法，其依据是发现本发明的抑制剂还能诱导白细胞 L-选择素粘附分子脱落。本发明还提供了通过钙调蛋白拮抗剂抑制炎症和淋巴结进入的方法，这种拮抗剂与 PDI 抑制剂一样，会引起白细胞 L-选择素脱落。
• Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA
  申请人：——

  公开号：US20030198648A1

  公开（公告）日：2003-10-23

  The present invention relates to methods of identifying a molecule from a library of molecules that inhibits binding of human immunodeficiency virus nucleocapsid 7 polypeptide (NCp7) to an oligonucleotide which comprises admixing an NCp7 polypeptide with at one labeled HIV-1 psi-site oligonucleotide and an amount of the molecule to be tested under binding conditions; and determining the amount of oligonucleotide bound to the NCp7 polypeptide, wherein a decrease in the amount of oligonucleotide bound in the presence of the molecule compared with the amount of oligonucleotide bound in the absence of the molecule indicates that the molecule inhibits binding of NCp7 polypeptide to the oligonucleotide.

  本发明涉及从抑制人类免疫缺陷病毒核壳7多肽（NCp7）与寡核苷酸结合的分子库中鉴定分子的方法，该方法包括在结合条件下将NCp7多肽与一个标记的HIV-1 psi-位点寡核苷酸和一定量的待测分子混合；确定与 NCp7 多肽结合的寡核苷酸量，其中，与没有该分子时结合的寡核苷酸量相比，有该分子时结合的寡核苷酸量减少，表明该分子抑制了 NCp7 多肽与寡核苷酸的结合。
• Roos, Chemische Berichte, 1888, vol. 21, p. 620
  作者：Roos

  DOI：——

  日期：——
• A METHOD FOR IDENTIFYING AND USING COMPOUNDS THAT INACTIVATE HIV-1 AND OTHER RETROVIRUSES BY ATTACKING HIGHLY CONSERVED ZINC FINGERS IN THE VIRAL NUCLEOCAPSID PROTEIN
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary of the Department of Health and Human Services

  公开号：EP0782632A1

  公开（公告）日：1997-07-09
• OLIGONUCLEOTIDES WHICH SPECIFICALLY BIND RETROVIRAL NUCLEOCAPSID PROTEINS
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP1011729B1

  公开（公告）日：2008-01-09