4-tert.-Butyl-1-methylcyclohexylamin | 742640-33-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-tert.-Butyl-1-methylcyclohexylamin
• 英文别名: 1-Amino-4-tert-butyl-1-methylcyclohexan；4-Tert-butyl-1-methylcyclohexan-1-amine
• CAS: 742640-33-1
• 化学式: C₁₁H₂₃N
• 分子量: 169.31
• InChiKey: IVYHDKYCLYPOJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-tert.-Butyl-1-methylcyclohexylamin 在 potassium permanganate 作用下， 生成 4-tert-Butyl-1-methyl-1-nitro-cyclohexane
  参考文献：
  名称：

  Kedzierski,B. et al., Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1971, vol. 19, p. 177 - 180

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(1,1-二甲基乙基)-1-甲基-环己醇 生成 4-tert.-Butyl-1-methylcyclohexylamin
  参考文献：
  名称：

  Thermal decomposition of N-chlorosulfonylurethanes. Conversion of alcohols to amines

  摘要：

  DOI：

  10.1021/ja00793a062

文献信息

• [EN] THIOPHENE COMPOUNDS WITH CYCLIC AMIDES, AND USES THEREOF<br/>[FR] COMPOSÉS THIOPHÈNE AYANT DES AMIDES CYCLIQUES, ET LEURS UTILISATIONS
  申请人：CAPULUS THERAPEUTICS LLC

  公开号：WO2021097123A1

  公开（公告）日：2021-05-20

  Provided herein are compounds comprising a four-ring core, such as compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Also provided herein are methods of inhibiting a component of the sterol regulatory element binding protein (SREBP) pathway, such as an SREBP or SREBP cleavage activating protein (SCAP), using these compounds, or pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Further provided are methods of treating a disorder in a subject in need thereof, such as liver disease, non-alcoholic steatohepatitis, insulin resistance, or cancer.

  本文提供了包含四环核心的化合物，例如Formula (I)和Formula (II)的化合物，以及这些化合物的药用盐、溶剂合物、互变异构体、同位素或同分异构体。本文还提供了使用这些化合物或其药用盐、溶剂合物、互变异构体、同位素或同分异构体来抑制类固醇调节元件结合蛋白（SREBP）途径的组分的方法，例如SREBP或SREBP裂解激活蛋白（SCAP）。此外，还提供了治疗患有肝病、非酒精性脂肪肝、胰岛素抵抗或癌症等疾病的方法。
• CYTOTOXIN AND CONJUGATE, USES OF SAME, AND PREPARATION METHOD THEREFOR
  申请人：Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

  公开号：EP3617221A1

  公开（公告）日：2020-03-04

  The present invention belongs to the technical field of medicine, and relates to a cytotoxin, a linker and a conjugate, a method for preparing the cytotoxin or the conjugate, and uses of the cytotoxin and of the conjugate in preventing and/or treating tumor diseases.

  本发明属于医学技术领域，涉及一种细胞毒素、连接体和共轭物，一种制备细胞毒素或共轭物的方法，以及细胞毒素和共轭物在预防和/或治疗肿瘤疾病中的用途。
• Isoxazole Carboxamide Compounds
  申请人：EPIZYME, INC.

  公开号：US20170190676A1

  公开（公告）日：2017-07-06

  The present disclosure provides substituted isoxazole carboxamide compounds having Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R 1 , R 2 , A, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
• SMYD Inhibitors
  申请人：EPIZYME, INC.

  公开号：US20170355695A1

  公开（公告）日：2017-12-14

  The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
• Thermal decomposition of N-chlorosulfonylurethanes. Conversion of alcohols to amines
  作者：James B. Hendrickson、Irving. Joffee

  DOI：10.1021/ja00793a062

  日期：1973.6