ethyl 4-(diethoxymethyl)cinnamate | 250639-00-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: ethyl 4-(diethoxymethyl)cinnamate
• 英文别名: (E)-ethyl 3-(4-(diethoxymethyl)phenyl)acrylate；ethyl (E)-3-[4-(diethoxymethyl)phenyl]prop-2-enoate
• CAS: 250639-00-0
• 化学式: C₁₆H₂₂O₄
• 分子量: 278.348
• InChiKey: KSDRYKVRIRUCPA-FMIVXFBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 4-(diethoxymethyl)cinnamate 在 5%-palladium/activated carbon 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 生成 Ethyl 3-[4-(diethoxymethyl)phenyl]propanoate
  参考文献：
  名称：

  GLYCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND MEDICINAL USE THEREOF

  摘要：

  公开号：

  EP1364957B1
• 作为产物：
  描述：

  对苯二甲醛缩二乙醛 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.67h， 生成 ethyl 4-(diethoxymethyl)cinnamate
  参考文献：
  名称：

  GLYCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND MEDICINAL USE THEREOF

  摘要：

  公开号：

  EP1364957B1

文献信息

• Glucopyranosyloxypyrazole derivatives and medicinal use thereof
  申请人：Nishimura Toshihiro

  公开号：US20060142209A1

  公开（公告）日：2006-06-29

  The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein one of Q and T represents a group represented by the general formula: while the other represents a lower alkyl group or a halo(lower alkyl) group; R 1 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkenyl group, a cyclic lower alkyl group, etc.; R 2 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkoxy group, a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkoxy group, etc., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.

  本发明提供一种由下式表示的葡萄糖吡唑衍生物：其中Q和T中的一个表示由下式表示的基团：而另一个表示较低的烷基或卤代（较低的烷基）基团；R1表示氢原子、可选地取代的较低烷基基团、较低烯基基团、环状较低烷基基团等；R2表示氢原子、可选地取代的较低烷基基团、较低烷氧基基团、较低烯基基团、环状较低烷基基团、环状较低烷氧基基团等，这些化合物在人类SGLT2中表现出优异的抑制活性，因此可用作预防或治疗与高血糖相关的疾病，如糖尿病、糖尿病并发症或肥胖症的药物，其药学上可接受的盐或前药，其生产中间体以及其制药用途。
• Glycopyranosyloxypyrazole derivatives and medicinal use thereof
  申请人：——

  公开号：US20040132669A1

  公开（公告）日：2004-07-08

  The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: 1 wherein one of Q and T represents a group represented by the general formula: 2 while the other represents a lower alkyl group or a halo(lower alkyl) group; R 1 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkenyl group, a cyclic lower alkyl group, etc.; R 2 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkoxy group, a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkoxy group, etc., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.

  本发明提供了一种由通式1表示的葡萄糖吡唑衍生物，其中Q和T中的一个表示由通式2表示的基团，而另一个表示较低的烷基基团或卤代（较低的烷基）基团；R1表示氢原子、可选取代的较低烷基基团、较低烯基基团、环状较低烷基基团等；R2表示氢原子、可选取代的较低烷基基团、较低烷氧基团、较低烯基基团、环状较低烷基基团、环状较低烷氧基团等。这些衍生物在人类SGLT2中具有出色的抑制活性，因此可用作预防或治疗与高血糖相关的疾病，如糖尿病、糖尿病并发症或肥胖症的药物，以及其药学上可接受的盐或前药、生产中间体及其制药用途。
• DI - SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS
  申请人：Takasu Hideki

  公开号：US20120283242A1

  公开（公告）日：2012-11-08

  The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R 1 and R 2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G 2 -, —N(lower alkyl)-G 2 -, —NH—CH 2 -G 2 -, —N(lower alkyl)-CH 2 -G 2 - or —CH 2 -G 2 -, [wherein G 2 binds to R 2 , G 2 -R 2 is bond-R 2 , phenylene-G 3 -R 2 , phenylene-G 4 -O—R 2 , phenylene-G 5 -NH—R 2 , phenylene-G 6 -N(lower alkyl)-R 2 or quinolinediyl-O—R 2 , the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G 3 -R 2 is —O-lower alkylene-R 2 or the like; G 4 -O— is lower alkylene-O— or the like; G 5 is lower alkylene; G 6 is lower alkylene].

  本发明提供了一种具有优异抗肿瘤效果的新型化合物。本发明的化合物由下述通式（1）表示，其中R1和R2为芳基或类似物；A为低级烷基；环X为可选取代的芳基；E为键或低级烯基；环Y为可选取代的杂环烷基，其中一个氮原子连接到相邻的羰基；G为—NH-G2-，—N(低级烷基)-G2-，—NH—CH2-G2-，—N(低级烷基)-CH2-G2-或—CH2-G2-，[其中G2与R2相连，G2-R2为键-R2，苯基-G3-R2，苯基-G4-O—R2，苯基-G5-NH—R2，苯基-G6-N(低级烷基)-R2或喹啉基-O—R2，所述苯基含有的苯基-含基团可选取代一个或多个取代基；G3-R2为—O-低级烷基-R2或类似物；G4-O—为低级烷基-O—或类似物；G5为低级烷基；G6为低级烷基]。
• Di-substituted pyridine derivatives as anticancers
  申请人：Takasu Hideki

  公开号：US08722663B2

  公开（公告）日：2014-05-13

  The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].

  本发明提供了一种具有优异抗肿瘤效果的新化合物。本发明的化合物由以下一般式（1）表示，其中R1和R2是芳基或类似物; A是低碳链烷基; 环X是可选取代的芳基; E是键或低碳链烯烃基; 环Y是可选取代的杂环烷基，其中含有一个或多个氮原子，其中一个与相邻的羰基团结合; G是—NH-G2-, —N（低碳基）-G2-, —NH—CH2-G2-, —N（低碳基）-CH2-G2-或—CH2-G2-, [其中G2与R2结合，G2-R2是键-R2，苯基-G3-R2，苯基-G4-O—R2，苯基-G5-NH—R2，苯基-G6-N（低碳基）-R2或喹啉基-O—R2，所述苯基含基团可选地取代; G3-R2是—O-低碳链烷基-R2或类似物; G4-O—是低碳链烷基-O—或类似物; G5是低碳链烷基; G6是低碳链烷基]。
• US7087579B2
  申请人：——

  公开号：US7087579B2

  公开（公告）日：2006-08-08