3-(2-phenyl-4-quinolinyl)benzoic acid ethyl ester | 332124-42-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(2-phenyl-4-quinolinyl)benzoic acid ethyl ester
• 英文别名: Ethyl 3-(2-phenylquinolin-4-yl)benzoate
• CAS: 332124-42-2
• 化学式: C₂₄H₁₉NO₂
• 分子量: 353.42
• InChiKey: YAFCZOHRVLEABE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氯-2-苯基喹啉 、 3-溴苯甲酸乙酯 在 CoCl₂ 吡啶 、 tetrabutylammonium tetrafluoroborate 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 以65%的产率得到3-(2-phenyl-4-quinolinyl)benzoic acid ethyl ester
  参考文献：
  名称：

  Cobalt-catalyzed electrochemical cross-coupling of functionalized phenyl halides with 4-chloroquinoline derivatives

  摘要：

  A novel electrochemical procedure allowing the synthesis of various 4-phenylquinoline derivatives in satisfactory to high yields is described. This method relies on a cobalt-catalyzed cross-coupling reaction of functionalized phenyl halides with 4-chloroquinoline derivatives and is conducted in a one-compartment cell using the sacrificial anode process. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01936-5

文献信息

• Efficient Cobalt-Catalyzed Formation of Unsymmetrical Biaryl Compounds and Its Application in the Synthesis of a Sartan Intermediate
  作者：Muriel Amatore、Corinne Gosmini

  DOI：10.1002/anie.200704402

  日期：2008.2.28
• Cobalt-catalyzed electrochemical cross-coupling of functionalized phenyl halides with 4-chloroquinoline derivatives
  作者：Erwan Le Gall、Corinne Gosmini、Jean-Yves Nédélec、Jacques Périchon

  DOI：10.1016/s0040-4039(00)01936-5

  日期：2001.1

  A novel electrochemical procedure allowing the synthesis of various 4-phenylquinoline derivatives in satisfactory to high yields is described. This method relies on a cobalt-catalyzed cross-coupling reaction of functionalized phenyl halides with 4-chloroquinoline derivatives and is conducted in a one-compartment cell using the sacrificial anode process. (C) 2000 Elsevier Science Ltd. All rights reserved.