4-hydroxy-3-(N,N-dimethylcarboxamido)-1-methyl-2(1H)-quinolone | 73281-55-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-hydroxy-3-(N,N-dimethylcarboxamido)-1-methyl-2(1H)-quinolone
• 英文别名: 4-hydroxy-N,N,1-trimethyl-2-oxoquinoline-3-carboxamide
• CAS: 73281-55-7
• 化学式: C₁₃H₁₄N₂O₃
• 分子量: 246.266
• InChiKey: ZXYXSSAQRIDPLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  60.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-甲基苯唑 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 6.5h， 生成 4-hydroxy-3-(N,N-dimethylcarboxamido)-1-methyl-2(1H)-quinolone
  参考文献：
  名称：

  Structure–activity relationships studies of the anti-angiogenic activities of linomide

  摘要：

  The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3-69 times more potent than linomide at inhibiting blood vessel formation in the CAM angiogenesis assay. These compounds possessed considerable anti-proliferative activity against isolated HUVEC cells with no activity against epithelial-derived prostate tumor cells. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00047-7

文献信息

• COPPOLA G. M.; HARDTMANN G. E., J. HETEROCYCL. CHEM., 1979, 16, NO 8, 1605-1610
  作者：COPPOLA G. M.、 HARDTMANN G. E.

  DOI：——

  日期：——
• Structure–activity relationships studies of the anti-angiogenic activities of linomide
  作者：Jiandong Shi、Zili Xiao、Michael A Ihnat、Chandrashekhar Kamat、Bulbul Pandit、Zhigen Hu、Pui-Kai Li

  DOI：10.1016/s0960-894x(03)00047-7

  日期：2003.3

  The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3-69 times more potent than linomide at inhibiting blood vessel formation in the CAM angiogenesis assay. These compounds possessed considerable anti-proliferative activity against isolated HUVEC cells with no activity against epithelial-derived prostate tumor cells. (C) 2003 Elsevier Science Ltd. All rights reserved.

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