3-(2-methoxyphenyl)propanoyl-phloroglucinol | 1364510-17-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(2-methoxyphenyl)propanoyl-phloroglucinol
• 英文别名: 0MTK14；3-(2-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
• CAS: 1364510-17-7
• 化学式: C₁₆H₁₆O₅
• 分子量: 288.3
• InChiKey: OBLIPZKKRUQPGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(2-甲氧基苯基）丙酸 、 3-(2-methoxyphenyl)propanoyl-phloroglucinol 生成 3,5-dihydroxy-2-(3-(2-methoxyphenyl)propanoyl)-4,6,6-triisopentylcyclohexa-2,4-dienone
  参考文献：
  名称：

  ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS

  摘要：

  本发明提供一种公式（I）的化合物或其盐，其中R1-R5具有规范中描述的任何值，以及包含公式（I）化合物的组合物。这些化合物可用作RNA聚合酶抑制剂和抗菌剂。

  公开号：

  US20130289128A1
• 作为产物：
  描述：

  2-乙酰基-3,5-双(苄氧基)苯酚 在 palladium on activated charcoal 、 氢气 、 sodium hydride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 16.5h， 生成 3-(2-methoxyphenyl)propanoyl-phloroglucinol
  参考文献：
  名称：

  New homoisoflavonoid analogues protect cells by regulating autophagy

  摘要：

  As a special group of naturally occurring flavonoids, homoisoflavonoids have been discovered as active components of several traditional Chinese medicines for nourishing heart and mind. In this study, twenty homoisoflavonoid analogues, including different substitution groups on rings A and B, as well as heteroaromatic B ring, were synthesized and evaluated for their cardioprotective and neuroprotective activities. In a H2O2-induced H9c2 cardiomyocytes injury assay, nine homoisoflavonoid analogues showed promising activities in the same level as the positive control, diazoxide. Six cardioprotective compounds with representative structure diversities were then evaluated for their neuroprotective effects on MPP+ induced SH-SY5Y cell injury model. Furthermore, autophagy inducing monodansylcadaverine (MDC) fluorescence staining methods and molecular docking studies indicated the action mechanism of these compounds may involve autophagy regulating via class I P13K signaling pathway. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2017.01.086

文献信息

• Arylpropionyl-triketone antibacterial agents
  申请人：Ebright Richard H.

  公开号：US10800725B2

  公开（公告）日：2020-10-13

  The invention provides a compound of formula (I): or a salt thereof, wherein R1-R5 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as RNA polymerase inhibitors and antibacterial agents.

  该发明提供了化合物的结构式(I)：或其盐，其中R1-R5具有规范中描述的任何值，以及包含结构式(I)化合物的组合物。这些化合物可用作RNA聚合酶抑制剂和抗菌剂。
• [EN] ANTIBACTERIAL AGENTS: PHLOROGLUCINOL DERIVATIVES<br/>[FR] AGENTS ANTIBACTÉRIENS : DÉRIVÉS DU PHLOROGLUCINOL
  申请人：UNIV RUTGERS

  公开号：WO2013103969A1

  公开（公告）日：2013-07-11

  The invention provides a compound of formula I: or a salt thereof, wherein R1-R3 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.

  本发明提供了化合物I的公式：或其盐，其中R1-R3具有规范中描述的任何值，以及包含化合物I的组合物。这些化合物可用作抗菌剂。
• ANTIBACTERIAL AGENTS: PHLOROGLUCINOL DERIVATIVES
  申请人：Rutgers, the State University of New Jersey

  公开号：US20150011647A1

  公开（公告）日：2015-01-08

  The invention provides a compound of formula I: or a salt thereof, wherein R 1 -R 3 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.
• US9517994B2
  申请人：——

  公开号：US9517994B2

  公开（公告）日：2016-12-13
• [EN] ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS<br/>[FR] AGENTS ANTIBACTÉRIENS À BASE D'ARYLPROPIONYL-TRICÉTONE
  申请人：UNIV RUTGERS

  公开号：WO2012033846A1

  公开（公告）日：2012-03-15

  The invention provides a compound of formula (I): or a salt thereof, wherein R1-R5 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as RNA polymerase inhibitors and antibacterial agents.