6'-(13-Hydroxytridecyl)spiro[3-oxatricyclo[3.2.1.11,5]nonane-7,2'-tricyclo[2.2.1.11,4]octane]-2-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 6'-(13-Hydroxytridecyl)spiro[3-oxatricyclo[3.2.1.11,5]nonane-7,2'-tricyclo[2.2.1.11,4]octane]-2-one
• 英文别名: 6'-(13-hydroxytridecyl)spiro[3-oxatricyclo[3.2.1.11,5]nonane-7,2'-tricyclo[2.2.1.11,4]octane]-2-one
• 化学式: C₂₈H₄₄O₃
• 分子量: 428.6
• InChiKey: ANZMOHLVVWBLGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  31
• 可旋转键数：
  13
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PEPTIDE COMPOSITION AND USES THEREOF
  申请人：Universidade do Minho

  公开号：EP3058936A2

  公开（公告）日：2016-08-24

  The current application discloses a composition that comprises at least one peptide with a sequence length of 6-12 amino acids, where 2-5 of those amino acids are cysteines for the treatment and cosmetics of animal hair, in preference human hair. There are several hair styling methods that involve breakage and reestablishment of disulfide bonds, allowing relaxation and straightening of the hair. However, the most effective methods currently used to modulate hair contain harmful chemicals. Thus there is a constant demand for formulations that efficiently model the hair fiber without damage. Thus, the present invention aims to provide a composition for treatment of the hair, including animal and human hair, without the use of chemicals harmful to the hair fiber and consumer health and uses of said compositions in shampoo, lotion, serum, cream, conditioner, foam, elixir, oil, aerosol or mask.

  本申请公开了一种组合物，该组合物包含至少一种序列长度为 6-12 个氨基酸的肽，其中 2-5 个氨基酸为半胱氨酸，用于动物毛发（尤其是人类毛发）的治疗和美容。 有几种头发定型方法涉及二硫键的断裂和重建，从而使头发松弛和拉直。然而，目前用于调节头发的最有效方法都含有有害化学物质。因此，人们一直需要能够有效地对头发纤维进行造型而不造成损伤的配方。 因此，本发明旨在提供一种用于治疗头发（包括动物和人类头发）的组合物，不使用对头发纤维和消费者健康有害的化学物质，并将所述组合物用于洗发水、洗液、精华素、膏霜、护发素、泡沫、酏剂、油、气雾剂或面膜中。
• Peptide composition and respective uses
  申请人：UNIVERSIDADE DO MINHO

  公开号：US10709655B2

  公开（公告）日：2020-07-14

  The present invention provides a composition that comprises at least one peptide with a sequence length of 6-12 amino acids, where 2-5 of those amino acids are cysteines for the treatment of the hair, including animal and human hair, without the use of chemicals harmful to the hair fiber and consumer health and uses of said compositions in shampoo, lotion, serum, cream, conditioner, foam, elixir, oil, aerosol or mask.

  本发明提供了一种组合物，该组合物包含至少一种序列长度为 6-12 个氨基酸的肽，其中 2-5 个氨基酸为半胱氨酸，用于治疗包括动物和人类毛发在内的毛发，无需使用对毛发纤维和消费者健康有害的化学物质，并可将所述组合物用于洗发水、乳液、精华液、膏霜、护发素、泡沫、酏剂、油、气雾剂或面膜中。
• PEPTIDE COMPOSITION AND RESPECTIVE USES
  申请人：UNIVERSIDADE DO MINHO

  公开号：US20190307666A1

  公开（公告）日：2019-10-10

  The present invention provides a composition that comprises at least one peptide with a sequence length of 6-12 amino acids, where 2-5 of those amino acids are cysteines for the treatment of the hair, including animal and human hair, without the use of chemicals harmful to the hair fiber and consumer health and uses of said compositions in shampoo, lotion, serum, cream, conditioner, foam, elixir, oil, aerosol or mask.
• [EN] SKIN COSMETIC COMPOSITION<br/>[FR] COMPOSITION COSMÉTIQUE DESTINÉE À LA PEAU<br/>[JA] 皮膚化粧料用組成物
  申请人：MANDOM CORP

  公开号：WO2020066895A1

  公开（公告）日：2020-04-02

  油分を比較的多量に含むことができ、且つ透明性及び保存安定性に優れる皮膚化粧料用組成物を提供する。　下記成分Ａと、下記成分Ｂと、下記成分Ｃと、下記成分Ｄと、下記成分Ｅと、下記成分Ｆと、下記成分Ｇと、下記成分Ｈとを含有し、前記成分Ａに対する前記成分Ｂの質量比（Ｂ／Ａ）が５．５～１８．０である皮膚化粧料用組成物。　成分Ａ：リン脂質　成分Ｂ：オキシエチレンの平均付加モル数が１５～５０のポリオキシエチレンステロールエーテル及び／又はオキシエチレンの平均付加モル数が１５～５０のポリオキシエチレンスタノールエーテル　成分Ｃ：分岐鎖を有する炭素数１２～２４の１価の脂肪族アルコール　成分Ｄ：プロピレングリコール、ジプロピレングリコール及び１，３－ブチレングリコールからなる群より選ばれた一種以上の多価アルコール　成分Ｅ：水　成分Ｆ：ステロール　成分Ｇ：油分　成分Ｈ：オキシエチレンの平均付加モル数が５～３０のポリオキシエチレン硬化ヒマシ油
• [EN] COMPOSITION FOR HAIR FOLLICLE MODULATION, METHODS AND USES THEREOF<br/>[FR] COMPOSITION POUR LA MODULATION DE FOLLICULES PILEUX, PROCÉDÉS ET UTILISATIONS ASSOCIÉS
  申请人：[en]UNIVERSIDADE DO MINHO

  公开号：WO2021260667A2

  公开（公告）日：2021-12-30

  The present disclosure relates to a composition for use in the hair follicle modulation comprising a bioactive agent a thickener agent; a preservative; and a denaturing alcohol. The present disclosure also comprises a pharmaceutical composition for use in the prevention, therapy or treatment of abnormal defective production of melanin, comprising a bioactive agent selected from dipyridamole, dipyridamole salt, rivastigmine, rivastigmine salt, paroxetine, paroxetine salt, or mixtures thereof. The use of said bioactive agent as a hair modulator is also encompassed.