Oleanderol | 114906-01-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Oleanderol
• 英文别名: (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13bR)-3a,5a-bis(hydroxymethyl)-5b,8,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13b-tetradecahydrocyclopenta[a]chrysen-9-ol
• CAS: 114906-01-3
• 化学式: C₃₀H₄₈O₃
• 分子量: 456.7
• InChiKey: MGVRARFPKYMFHG-ZFTKPFTMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin
  申请人：Xu Ze-Qi

  公开号：US20070232577A1

  公开（公告）日：2007-10-04

  The present invention comprises small molecule inhibitors of cell proliferative conditions, in particular cancer and conditions associated with cancer. For example, associated malignancies include ovarian cancer, cervical cancer, breast cancer, colorectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases. Thus, the present invention also comprising pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to inhibit cancer and treat, prevent, or inhibit the foregoing diseases.

  本发明包括细胞增殖状况的小分子抑制剂，特别是癌症及与癌症相关的状况。例如，相关的恶性肿瘤包括卵巢癌、宫颈癌、乳腺癌、结直肠癌和胶质母细胞瘤等。因此，本发明的化合物对于治疗、预防和/或抑制这些疾病是有用的。因此，本发明还包括包含这些化合物的药物配方以及使用这些化合物和配方来抑制癌症并治疗、预防或抑制上述疾病的方法。
• Method and compostitions for treating coronavirus infection
  申请人：PHOENIX BIOTECHNOLOGY, INC.

  公开号：US10729735B1

  公开（公告）日：2020-08-04

  A method of treating viral infection, such as viral infection caused by a virus of the Coronaviridae family, is provided. A composition having at least oleandrin is used to treat viral infection.

  提供了一种治疗病毒感染的方法，例如由冠状病毒科病毒引起的病毒感染。一种至少含有齐墩果素的组合物用于治疗病毒感染。
• SYNTHETIC PENTACYCLIC TRITERPENOIDS AND DERIVATIVES OF BETULINIC ACID AND BETULIN
  申请人：Advanced Life Sciences Inc.

  公开号：EP1996205A2

  公开（公告）日：2008-12-03
• METHOD AND COMPOSITIONS FOR TREATING CORONAVIRUS INFECTION
  申请人：Phoenix Biotechnology, Inc.

  公开号：EP4009981A1

  公开（公告）日：2022-06-15
• Method and Compositions for Treating Coronavirus Infection
  申请人：PHOENIX BIOTECHNOLOGY, INC.

  公开号：US20220054521A1

  公开（公告）日：2022-02-24

  A method of treating viral infection, such as viral infection caused by a virus of the Coronaviridae family, is provided. A composition having at least oleandrin is used to treat viral infection.